HIV-1 exploits LBPA-dependent intraepithelial trafficking for productive infection of human intestinal mucosa.

HIV-1 exploits LBPA-dependent intraepithelial trafficking for productive infection of human intestinal mucosa.

The gastrointestinal tract is a prominent portal of entry for HIV-1 during sexual or perinatal transmission, as well as a major site of HIV-1 persistence and replication. Elucidation of underlying mechanisms of intestinal HIV-1 infection are thus needed for the advancement of HIV-1 curative therapie...

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Main Authors: Anusca G Rader, Alexandra P M Cloherty, Kharishma S Patel, Dima D A Almandawi, Dasja Pajkrt, Katja C Wolthers, Adithya Sridhar, Sterre van Piggelen, Liselotte E Baaij, Renée R C E Schreurs, Carla M S Ribeiro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012714
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