Gene editing of pigs to control influenza A virus infections

Gene editing of pigs to control influenza A virus infections

Proteolytic activation of the haemagglutinin (HA) glycoprotein by host cellular proteases is pivotal for influenza A virus (IAV) infectivity. Highly pathogenic avian influenza viruses possess the multibasic cleavage site of the HA which is cleaved by ubiquitous proteases, such as furin; in contrast,...

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Bibliographic Details
Main Authors: Taeyong Kwon, Bianca L. Artiaga, Chester D. McDowell, Kristin M. Whitworth, Kevin D. Wells, Randall S. Prather, Gustavo Delhon, Mark Cigan, Stephen N. White, Jamie Retallick, Natasha N. Gaudreault, Igor Morozov, Juergen A. Richt
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
Gene editing
influenza A virus
knockout pigs
transmembrane serine protease 2
TMPRRS2
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2024.2387449
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