CD8α Structural Domains Enhance GUCY2C CAR-T Cell Efficacy

CD8α Structural Domains Enhance GUCY2C CAR-T Cell Efficacy

Despite success in treating some hematological malignancies, CAR-T cells have not yet produced similar outcomes in solid tumors due, in part, to the tumor microenvironment, poor persistence, and a paucity of suitable target antigens. Importantly, the impact of the CAR components on these challenges...

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Bibliographic Details
Main Authors: Trevor R. Baybutt, Ariana A. Entezari, Adi Caspi, Ross E. Staudt, Robert D. Carlson, Scott A. Waldman, Adam E. Snook
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Cancer Biology & Therapy
Subjects:
Chimeric antigen receptor
CAR-T cell therapy
GUCY2C
colorectal cancer
Online Access:https://www.tandfonline.com/doi/10.1080/15384047.2024.2398801
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