Percutaneous Ultrasound-Guided Radiofrequency Ablation as a Therapeutic Approach for the Management of Insulinomas and Associated Metastases in Dogs
Insulinomas are the most common neoplasms of the endocrine pancreas in dogs, leading to persistent hypoglycemia due to inappropriate insulin secretion. The standard treatment is surgical resection, but it carries significant risks, including pancreatitis and diabetes mellitus. This study investigate...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Animals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2615/14/22/3301 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850216907526897664 |
|---|---|
| author | María Dolores Alférez Andrea Corda Ignacio de Blas Lucas Gago Telmo Fernandes Ignacio Rodríguez-Piza Beatriz Balañá Francesca Corda Pablo Gómez Ochoa |
| author_facet | María Dolores Alférez Andrea Corda Ignacio de Blas Lucas Gago Telmo Fernandes Ignacio Rodríguez-Piza Beatriz Balañá Francesca Corda Pablo Gómez Ochoa |
| author_sort | María Dolores Alférez |
| collection | DOAJ |
| description | Insulinomas are the most common neoplasms of the endocrine pancreas in dogs, leading to persistent hypoglycemia due to inappropriate insulin secretion. The standard treatment is surgical resection, but it carries significant risks, including pancreatitis and diabetes mellitus. This study investigates the efficacy and safety of percutaneous ultrasound-guided radiofrequency ablation (RFA) as an alternative to surgery. A total of 29 dogs diagnosed with insulinoma were treated with RFA, targeting both primary pancreatic tumors and metastases in regional lymph nodes or the liver. Blood glucose levels and tumor size were monitored before and after the procedure. RFA led to a significant increase in blood glucose levels and a reduction in tumor size in all patients, with minimal postoperative complications. The results suggest that RFA is a feasible and effective treatment option for insulinomas in dogs. |
| format | Article |
| id | doaj-art-c3e4229678874765832f15c0a78e926e |
| institution | OA Journals |
| issn | 2076-2615 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj-art-c3e4229678874765832f15c0a78e926e2025-08-20T02:08:11ZengMDPI AGAnimals2076-26152024-11-011422330110.3390/ani14223301Percutaneous Ultrasound-Guided Radiofrequency Ablation as a Therapeutic Approach for the Management of Insulinomas and Associated Metastases in DogsMaría Dolores Alférez0Andrea Corda1Ignacio de Blas2Lucas Gago3Telmo Fernandes4Ignacio Rodríguez-Piza5Beatriz Balañá6Francesca Corda7Pablo Gómez Ochoa8VetCorner Unavets, 50012 Zaragoza, SpainDepartment of Veterinary Medicine, University of Sassari, 07100 Sassari, ItalyDepartment of Animal Pathology, University of Zaragoza, 50013 Zaragoza, SpainDepartment of Mathematics and Computer Science, University of Barcelona, 08007 Barcelona, SpainImaginologia Veterinaria do Porto, 4490-479 Porto, PortugalAnicura Glòries Hospital Veterinari, 08010 Barcelona, SpainHospital Aralar Veterinarios, 50410 Zaragoza, SpainDepartment of Veterinary Medicine, University of Sassari, 07100 Sassari, ItalyVetCorner Unavets, 50012 Zaragoza, SpainInsulinomas are the most common neoplasms of the endocrine pancreas in dogs, leading to persistent hypoglycemia due to inappropriate insulin secretion. The standard treatment is surgical resection, but it carries significant risks, including pancreatitis and diabetes mellitus. This study investigates the efficacy and safety of percutaneous ultrasound-guided radiofrequency ablation (RFA) as an alternative to surgery. A total of 29 dogs diagnosed with insulinoma were treated with RFA, targeting both primary pancreatic tumors and metastases in regional lymph nodes or the liver. Blood glucose levels and tumor size were monitored before and after the procedure. RFA led to a significant increase in blood glucose levels and a reduction in tumor size in all patients, with minimal postoperative complications. The results suggest that RFA is a feasible and effective treatment option for insulinomas in dogs.https://www.mdpi.com/2076-2615/14/22/3301insulinomaradiofrequency ablationcaninehypoglycemiapancreatic tumormetastases |
| spellingShingle | María Dolores Alférez Andrea Corda Ignacio de Blas Lucas Gago Telmo Fernandes Ignacio Rodríguez-Piza Beatriz Balañá Francesca Corda Pablo Gómez Ochoa Percutaneous Ultrasound-Guided Radiofrequency Ablation as a Therapeutic Approach for the Management of Insulinomas and Associated Metastases in Dogs Animals insulinoma radiofrequency ablation canine hypoglycemia pancreatic tumor metastases |
| title | Percutaneous Ultrasound-Guided Radiofrequency Ablation as a Therapeutic Approach for the Management of Insulinomas and Associated Metastases in Dogs |
| title_full | Percutaneous Ultrasound-Guided Radiofrequency Ablation as a Therapeutic Approach for the Management of Insulinomas and Associated Metastases in Dogs |
| title_fullStr | Percutaneous Ultrasound-Guided Radiofrequency Ablation as a Therapeutic Approach for the Management of Insulinomas and Associated Metastases in Dogs |
| title_full_unstemmed | Percutaneous Ultrasound-Guided Radiofrequency Ablation as a Therapeutic Approach for the Management of Insulinomas and Associated Metastases in Dogs |
| title_short | Percutaneous Ultrasound-Guided Radiofrequency Ablation as a Therapeutic Approach for the Management of Insulinomas and Associated Metastases in Dogs |
| title_sort | percutaneous ultrasound guided radiofrequency ablation as a therapeutic approach for the management of insulinomas and associated metastases in dogs |
| topic | insulinoma radiofrequency ablation canine hypoglycemia pancreatic tumor metastases |
| url | https://www.mdpi.com/2076-2615/14/22/3301 |
| work_keys_str_mv | AT mariadoloresalferez percutaneousultrasoundguidedradiofrequencyablationasatherapeuticapproachforthemanagementofinsulinomasandassociatedmetastasesindogs AT andreacorda percutaneousultrasoundguidedradiofrequencyablationasatherapeuticapproachforthemanagementofinsulinomasandassociatedmetastasesindogs AT ignaciodeblas percutaneousultrasoundguidedradiofrequencyablationasatherapeuticapproachforthemanagementofinsulinomasandassociatedmetastasesindogs AT lucasgago percutaneousultrasoundguidedradiofrequencyablationasatherapeuticapproachforthemanagementofinsulinomasandassociatedmetastasesindogs AT telmofernandes percutaneousultrasoundguidedradiofrequencyablationasatherapeuticapproachforthemanagementofinsulinomasandassociatedmetastasesindogs AT ignaciorodriguezpiza percutaneousultrasoundguidedradiofrequencyablationasatherapeuticapproachforthemanagementofinsulinomasandassociatedmetastasesindogs AT beatrizbalana percutaneousultrasoundguidedradiofrequencyablationasatherapeuticapproachforthemanagementofinsulinomasandassociatedmetastasesindogs AT francescacorda percutaneousultrasoundguidedradiofrequencyablationasatherapeuticapproachforthemanagementofinsulinomasandassociatedmetastasesindogs AT pablogomezochoa percutaneousultrasoundguidedradiofrequencyablationasatherapeuticapproachforthemanagementofinsulinomasandassociatedmetastasesindogs |