Increased corneal epithelial turnover contributes to abnormal homeostasis in the Pax6(+/-) mouse model of aniridia.

Increased corneal epithelial turnover contributes to abnormal homeostasis in the Pax6(+/-) mouse model of aniridia.

We aimed to test previous predictions that limbal epithelial stem cells (LESCs) are quantitatively deficient or qualitatively defective in Pax6(+/-) mice and decline with age in wild-type (WT) mice. Consistent with previous studies, corneal epithelial stripe patterns coarsened with age in WT mosaics...

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Main Authors: Panagiotis Douvaras, Richard L Mort, Dominic Edwards, Kanna Ramaesh, Baljean Dhillon, Steven D Morley, Robert E Hill, John D West
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0071117&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0071117&type=printable

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