Risk Factors for Glaucoma Suspicion in Healthy Young Asian and Caucasian Americans
Purpose. To determine the prevalence of certain risk factors for glaucoma in a healthy, young population and to compare these risk factors between Asian Americans and Caucasians. Methods. 120 healthy graduate students (mean age 24.8±3.0 years) underwent a comprehensive ophthalmic examination. Regres...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2014/726760 |
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| author | E. Lauren Doss Linden Doss Ying Han Susan Huang Travis Porco Melike Pekmezci Shan Lin |
| author_facet | E. Lauren Doss Linden Doss Ying Han Susan Huang Travis Porco Melike Pekmezci Shan Lin |
| author_sort | E. Lauren Doss |
| collection | DOAJ |
| description | Purpose. To determine the prevalence of certain risk factors for glaucoma in a healthy, young population and to compare these risk factors between Asian Americans and Caucasians. Methods. 120 healthy graduate students (mean age 24.8±3.0 years) underwent a comprehensive ophthalmic examination. Regression analyses controlling for age, sex, and refraction, comparing glaucoma risk factors in Asians (n=54) and Caucasians (n=41), were performed. Outcome variables included family history, intraocular pressure (IOP), spherical equivalent, central corneal thickness (CCT), mean deviation (MD) and pattern standard deviation (PSD), and disc and retinal nerve fiber layer (RNFL) parameters. Results. 61% of subjects were female; the mean spherical equivalent was -3.81±3.2 D; and the mean axial length (AL) was 25.1±1.7 mm. Regression analysis showed race affected spherical equivalent (P<0.001), AL (P=0.0073), IOP (P<0.001), and cup to disc area ratio (CDAR) (P=0.012). Family history, CCT, MD, and PSD did not vary between Asians and Caucasians (P>0.05). In this study, we found Asian Americans, compared to Caucasians, had 2.95±0.64 D greater myopia; greater IOP by 2.74±0.62 mmHg; and larger CDAR by 0.12±0.046. Conclusions. In our study population, young, healthy Asian Americans had greater myopia, IOP, and CDAR as compared to Caucasians, suggesting that racial variations can be important when diagnosing glaucoma. |
| format | Article |
| id | doaj-art-c3e10c6ed4124ee3b74df4f50bac1cbb |
| institution | DOAJ |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-c3e10c6ed4124ee3b74df4f50bac1cbb2025-08-20T03:23:12ZengWileyJournal of Ophthalmology2090-004X2090-00582014-01-01201410.1155/2014/726760726760Risk Factors for Glaucoma Suspicion in Healthy Young Asian and Caucasian AmericansE. Lauren Doss0Linden Doss1Ying Han2Susan Huang3Travis Porco4Melike Pekmezci5Shan Lin6Department of Ophthalmology, University of California, 10 Koret Way, San Francisco, CA 94143-0730, USASchool of Medicine, Loma Linda University, Anderson Street, Loma Linda, CA 92354, USADepartment of Ophthalmology, University of California, 10 Koret Way, San Francisco, CA 94143-0730, USADepartment of Ophthalmology, University of California, 10 Koret Way, San Francisco, CA 94143-0730, USADepartment of Ophthalmology, University of California, 10 Koret Way, San Francisco, CA 94143-0730, USADepartment of Pathology and Laboratory Medicine, University of California, Parnassus Avenue S512, San Francisco, CA 94143, USADepartment of Ophthalmology, University of California, 10 Koret Way, San Francisco, CA 94143-0730, USAPurpose. To determine the prevalence of certain risk factors for glaucoma in a healthy, young population and to compare these risk factors between Asian Americans and Caucasians. Methods. 120 healthy graduate students (mean age 24.8±3.0 years) underwent a comprehensive ophthalmic examination. Regression analyses controlling for age, sex, and refraction, comparing glaucoma risk factors in Asians (n=54) and Caucasians (n=41), were performed. Outcome variables included family history, intraocular pressure (IOP), spherical equivalent, central corneal thickness (CCT), mean deviation (MD) and pattern standard deviation (PSD), and disc and retinal nerve fiber layer (RNFL) parameters. Results. 61% of subjects were female; the mean spherical equivalent was -3.81±3.2 D; and the mean axial length (AL) was 25.1±1.7 mm. Regression analysis showed race affected spherical equivalent (P<0.001), AL (P=0.0073), IOP (P<0.001), and cup to disc area ratio (CDAR) (P=0.012). Family history, CCT, MD, and PSD did not vary between Asians and Caucasians (P>0.05). In this study, we found Asian Americans, compared to Caucasians, had 2.95±0.64 D greater myopia; greater IOP by 2.74±0.62 mmHg; and larger CDAR by 0.12±0.046. Conclusions. In our study population, young, healthy Asian Americans had greater myopia, IOP, and CDAR as compared to Caucasians, suggesting that racial variations can be important when diagnosing glaucoma.http://dx.doi.org/10.1155/2014/726760 |
| spellingShingle | E. Lauren Doss Linden Doss Ying Han Susan Huang Travis Porco Melike Pekmezci Shan Lin Risk Factors for Glaucoma Suspicion in Healthy Young Asian and Caucasian Americans Journal of Ophthalmology |
| title | Risk Factors for Glaucoma Suspicion in Healthy Young Asian and Caucasian Americans |
| title_full | Risk Factors for Glaucoma Suspicion in Healthy Young Asian and Caucasian Americans |
| title_fullStr | Risk Factors for Glaucoma Suspicion in Healthy Young Asian and Caucasian Americans |
| title_full_unstemmed | Risk Factors for Glaucoma Suspicion in Healthy Young Asian and Caucasian Americans |
| title_short | Risk Factors for Glaucoma Suspicion in Healthy Young Asian and Caucasian Americans |
| title_sort | risk factors for glaucoma suspicion in healthy young asian and caucasian americans |
| url | http://dx.doi.org/10.1155/2014/726760 |
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