Impact of Immunosenescence on Immune‐Related Adverse Events in Elderly Patients With Cancer
ABSTRACT Immune checkpoint inhibitors (ICI), have transformed the management of several types of cancers; however, immune‐related adverse events (irAEs) may cause treatment interruptions, chronic toxic effects, and death. Elderly patients are at high risk of cancer. Compared with traditional chemoth...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | Aging Medicine |
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| Online Access: | https://doi.org/10.1002/agm2.70000 |
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| author | Jiayi Gao Yue Yuan Xue Wang Liuer He Lin Li |
| author_facet | Jiayi Gao Yue Yuan Xue Wang Liuer He Lin Li |
| author_sort | Jiayi Gao |
| collection | DOAJ |
| description | ABSTRACT Immune checkpoint inhibitors (ICI), have transformed the management of several types of cancers; however, immune‐related adverse events (irAEs) may cause treatment interruptions, chronic toxic effects, and death. Elderly patients are at high risk of cancer. Compared with traditional chemotherapy, immunotherapy has become a better alternative choice for elderly patients with cancer due to its high efficiency and low toxicity. However, the emergence of immunosenescence accompanied by advancing age raises safety concerns for ICI. Therefore, we summarize the characteristics of irAEs occurred in elderly patients with cancer and the physiological characteristics of immunosenescence, which will lay a theoretical foundation for the safety management of immunotherapy in elderly patients with cancer. |
| format | Article |
| id | doaj-art-c3dfdbc79c214875b87372f4150ef1ce |
| institution | OA Journals |
| issn | 2475-0360 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Aging Medicine |
| spelling | doaj-art-c3dfdbc79c214875b87372f4150ef1ce2025-08-20T02:11:13ZengWileyAging Medicine2475-03602025-02-0181n/an/a10.1002/agm2.70000Impact of Immunosenescence on Immune‐Related Adverse Events in Elderly Patients With CancerJiayi Gao0Yue Yuan1Xue Wang2Liuer He3Lin Li4Department of Oncology, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing People's Republic of ChinaDepartment of Oncology, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing People's Republic of ChinaDepartment of Oncology, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing People's Republic of ChinaDepartment of Oncology, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing People's Republic of ChinaDepartment of Oncology, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Beijing People's Republic of ChinaABSTRACT Immune checkpoint inhibitors (ICI), have transformed the management of several types of cancers; however, immune‐related adverse events (irAEs) may cause treatment interruptions, chronic toxic effects, and death. Elderly patients are at high risk of cancer. Compared with traditional chemotherapy, immunotherapy has become a better alternative choice for elderly patients with cancer due to its high efficiency and low toxicity. However, the emergence of immunosenescence accompanied by advancing age raises safety concerns for ICI. Therefore, we summarize the characteristics of irAEs occurred in elderly patients with cancer and the physiological characteristics of immunosenescence, which will lay a theoretical foundation for the safety management of immunotherapy in elderly patients with cancer.https://doi.org/10.1002/agm2.70000elderly patientsimmune checkpoint inhibitorsimmune‐related adverse eventsimmunosenescence |
| spellingShingle | Jiayi Gao Yue Yuan Xue Wang Liuer He Lin Li Impact of Immunosenescence on Immune‐Related Adverse Events in Elderly Patients With Cancer Aging Medicine elderly patients immune checkpoint inhibitors immune‐related adverse events immunosenescence |
| title | Impact of Immunosenescence on Immune‐Related Adverse Events in Elderly Patients With Cancer |
| title_full | Impact of Immunosenescence on Immune‐Related Adverse Events in Elderly Patients With Cancer |
| title_fullStr | Impact of Immunosenescence on Immune‐Related Adverse Events in Elderly Patients With Cancer |
| title_full_unstemmed | Impact of Immunosenescence on Immune‐Related Adverse Events in Elderly Patients With Cancer |
| title_short | Impact of Immunosenescence on Immune‐Related Adverse Events in Elderly Patients With Cancer |
| title_sort | impact of immunosenescence on immune related adverse events in elderly patients with cancer |
| topic | elderly patients immune checkpoint inhibitors immune‐related adverse events immunosenescence |
| url | https://doi.org/10.1002/agm2.70000 |
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