Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation
Background. Acne is a dermatosis that involves an altered sebum pattern. Objectives. (1) To evaluate if a treatment based on antibiotics (lymecycline) can alter fatty acids contents of the sebum of patients with acne; (2) to evaluate if oral supplementation of fatty acids can interfere with fatty ac...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/120475 |
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| author | Adilson Costa Aline Siqueira Talarico Carla de Oliveira Parra Duarte Caroline Silva Pereira Ellem Tatiani de Souza Weimann Lissa Sabino de Matos Livia Carolina Della Coletta Maria Carolina Fidelis Thaísa Saddi Tannous Cidia Vasconcellos |
| author_facet | Adilson Costa Aline Siqueira Talarico Carla de Oliveira Parra Duarte Caroline Silva Pereira Ellem Tatiani de Souza Weimann Lissa Sabino de Matos Livia Carolina Della Coletta Maria Carolina Fidelis Thaísa Saddi Tannous Cidia Vasconcellos |
| author_sort | Adilson Costa |
| collection | DOAJ |
| description | Background. Acne is a dermatosis that involves an altered sebum pattern. Objectives. (1) To evaluate if a treatment based on antibiotics (lymecycline) can alter fatty acids contents of the sebum of patients with acne; (2) to evaluate if oral supplementation of fatty acids can interfere with fatty acids contents of the sebum of patients with acne; (3) to evaluate if there is any interaction in fatty acids contents of the sebum of patients with acne when they use both antibiotics and oral supplementation of fatty acids. Methods. Forty-five male volunteers with inflammatory acne vulgaris were treated with 300 mg of lymecycline per day, with 540 mg of γ-linolenic acid, 1,200 mg of linoleic acid, and 510 mg of oleic acid per day, or with both regimens for 90 days. Every 30 days, a sample of sebum from the forehead was collected for fatty acids’ chromatographic analysis. Results. Twelve fatty acids studied exhibited some kind of pattern changes during the study: C12:0, C14:0, C15:0, C16:1, C18:0, C18:1n9c+C18:1n9t, C18:2n6t, C18:3n6, C18:3n3, C20:1, C22:0, and C24:0. Conclusions. The daily administration of lymecycline and/or specific fatty acids may slightly influence some fatty acids levels present in the sebum of patients with inflammatory acne vulgaris. |
| format | Article |
| id | doaj-art-c3deda81222e4605bd55142be5bbb100 |
| institution | OA Journals |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-c3deda81222e4605bd55142be5bbb1002025-08-20T02:18:57ZengWileyDermatology Research and Practice1687-61051687-61132013-01-01201310.1155/2013/120475120475Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid SupplementationAdilson Costa0Aline Siqueira Talarico1Carla de Oliveira Parra Duarte2Caroline Silva Pereira3Ellem Tatiani de Souza Weimann4Lissa Sabino de Matos5Livia Carolina Della Coletta6Maria Carolina Fidelis7Thaísa Saddi Tannous8Cidia Vasconcellos9Service of Dermatology of the Pontifical Catholic University of Campinas, Campinas, SP, BrazilService of Dermatology of the Pontifical Catholic University of Campinas, Campinas, SP, BrazilService of Dermatology of the Pontifical Catholic University of Campinas, Campinas, SP, BrazilService of Dermatology of the Pontifical Catholic University of Campinas, Campinas, SP, BrazilService of Dermatology of the Pontifical Catholic University of Campinas, Campinas, SP, BrazilService of Dermatology of the Pontifical Catholic University of Campinas, Campinas, SP, BrazilService of Dermatology of the Pontifical Catholic University of Campinas, Campinas, SP, BrazilService of Dermatology of the Pontifical Catholic University of Campinas, Campinas, SP, BrazilService of Dermatology of the Pontifical Catholic University of Campinas, Campinas, SP, BrazilDepartment of Dermatology of the University of Sao Paulo, Sao Paulo, SP, BrazilBackground. Acne is a dermatosis that involves an altered sebum pattern. Objectives. (1) To evaluate if a treatment based on antibiotics (lymecycline) can alter fatty acids contents of the sebum of patients with acne; (2) to evaluate if oral supplementation of fatty acids can interfere with fatty acids contents of the sebum of patients with acne; (3) to evaluate if there is any interaction in fatty acids contents of the sebum of patients with acne when they use both antibiotics and oral supplementation of fatty acids. Methods. Forty-five male volunteers with inflammatory acne vulgaris were treated with 300 mg of lymecycline per day, with 540 mg of γ-linolenic acid, 1,200 mg of linoleic acid, and 510 mg of oleic acid per day, or with both regimens for 90 days. Every 30 days, a sample of sebum from the forehead was collected for fatty acids’ chromatographic analysis. Results. Twelve fatty acids studied exhibited some kind of pattern changes during the study: C12:0, C14:0, C15:0, C16:1, C18:0, C18:1n9c+C18:1n9t, C18:2n6t, C18:3n6, C18:3n3, C20:1, C22:0, and C24:0. Conclusions. The daily administration of lymecycline and/or specific fatty acids may slightly influence some fatty acids levels present in the sebum of patients with inflammatory acne vulgaris.http://dx.doi.org/10.1155/2013/120475 |
| spellingShingle | Adilson Costa Aline Siqueira Talarico Carla de Oliveira Parra Duarte Caroline Silva Pereira Ellem Tatiani de Souza Weimann Lissa Sabino de Matos Livia Carolina Della Coletta Maria Carolina Fidelis Thaísa Saddi Tannous Cidia Vasconcellos Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation Dermatology Research and Practice |
| title | Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation |
| title_full | Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation |
| title_fullStr | Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation |
| title_full_unstemmed | Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation |
| title_short | Evaluation of the Quantitative and Qualitative Alterations in the Fatty Acid Contents of the Sebum of Patients with Inflammatory Acne during Treatment with Systemic Lymecycline and/or Oral Fatty Acid Supplementation |
| title_sort | evaluation of the quantitative and qualitative alterations in the fatty acid contents of the sebum of patients with inflammatory acne during treatment with systemic lymecycline and or oral fatty acid supplementation |
| url | http://dx.doi.org/10.1155/2013/120475 |
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