Filling the gap in CNS drug development: evaluation of the role of drug repurposing
Background and objective: Background and objective: Drug repurposing has been considered a cost-effective and reduced-risk strategy for developing new drugs. Little is known and documented regarding the efficiency of repurposing strategies in drug development. The objective of this article is to ass...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-01-01
|
| Series: | Journal of Market Access & Health Policy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20016689.2017.1299833 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850045626453065728 |
|---|---|
| author | A. Caban K. Pisarczyk K. Kopacz A. Kapuśniak M. Toumi C. Rémuzat A. Kornfeld |
| author_facet | A. Caban K. Pisarczyk K. Kopacz A. Kapuśniak M. Toumi C. Rémuzat A. Kornfeld |
| author_sort | A. Caban |
| collection | DOAJ |
| description | Background and objective: Background and objective: Drug repurposing has been considered a cost-effective and reduced-risk strategy for developing new drugs. Little is known and documented regarding the efficiency of repurposing strategies in drug development. The objective of this article is to assess the extent and meaning of this process in the CNS area. Methods: In order to identify repurposed drugs that target the CNS, an extensive search was performed. For each identified case, its initial and target indication, development status and the type of repurposing strategy (repositioning, reformulation or both) was recorded. Results: One hundred and eighteen source products were identified. They were repurposed (mainly repositioned) 203 times with 81 products repurposed once and 38 products repurposed twice or more. The highest number of source drugs originated from the CNS area. Alzheimer’s disease was targeted most often. Half of the new indications were approved. Regarding repurposing within the CNS area, epilepsy, schizophrenia and depression were the richest sources of repurposed drugs. Conclusions: Repurposing drugs into CNS is an efficient and very active drug development method, exemplified by the considerable number of new indications that have been found via this strategy, with approximately half of the target indications currently under development. |
| format | Article |
| id | doaj-art-c3debebcc3884e70babf965b316205ee |
| institution | DOAJ |
| issn | 2001-6689 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Market Access & Health Policy |
| spelling | doaj-art-c3debebcc3884e70babf965b316205ee2025-08-20T02:54:39ZengMDPI AGJournal of Market Access & Health Policy2001-66892017-01-015110.1080/20016689.2017.12998331299833Filling the gap in CNS drug development: evaluation of the role of drug repurposingA. Caban0K. Pisarczyk1K. Kopacz2A. Kapuśniak3M. Toumi4C. Rémuzat5A. Kornfeld6Creativ-CeuticalCreativ-CeuticalCreativ-CeuticalCreativ-CeuticalAix-Marseille Université, Université de la MéditerranéeCreativ-CeuticalCreativ-CeuticalBackground and objective: Background and objective: Drug repurposing has been considered a cost-effective and reduced-risk strategy for developing new drugs. Little is known and documented regarding the efficiency of repurposing strategies in drug development. The objective of this article is to assess the extent and meaning of this process in the CNS area. Methods: In order to identify repurposed drugs that target the CNS, an extensive search was performed. For each identified case, its initial and target indication, development status and the type of repurposing strategy (repositioning, reformulation or both) was recorded. Results: One hundred and eighteen source products were identified. They were repurposed (mainly repositioned) 203 times with 81 products repurposed once and 38 products repurposed twice or more. The highest number of source drugs originated from the CNS area. Alzheimer’s disease was targeted most often. Half of the new indications were approved. Regarding repurposing within the CNS area, epilepsy, schizophrenia and depression were the richest sources of repurposed drugs. Conclusions: Repurposing drugs into CNS is an efficient and very active drug development method, exemplified by the considerable number of new indications that have been found via this strategy, with approximately half of the target indications currently under development.http://dx.doi.org/10.1080/20016689.2017.1299833Drug repurposingdrug repositioningdrug reprofilingdrug retaskingcentral nervous systempsychiatryneurology |
| spellingShingle | A. Caban K. Pisarczyk K. Kopacz A. Kapuśniak M. Toumi C. Rémuzat A. Kornfeld Filling the gap in CNS drug development: evaluation of the role of drug repurposing Journal of Market Access & Health Policy Drug repurposing drug repositioning drug reprofiling drug retasking central nervous system psychiatry neurology |
| title | Filling the gap in CNS drug development: evaluation of the role of drug repurposing |
| title_full | Filling the gap in CNS drug development: evaluation of the role of drug repurposing |
| title_fullStr | Filling the gap in CNS drug development: evaluation of the role of drug repurposing |
| title_full_unstemmed | Filling the gap in CNS drug development: evaluation of the role of drug repurposing |
| title_short | Filling the gap in CNS drug development: evaluation of the role of drug repurposing |
| title_sort | filling the gap in cns drug development evaluation of the role of drug repurposing |
| topic | Drug repurposing drug repositioning drug reprofiling drug retasking central nervous system psychiatry neurology |
| url | http://dx.doi.org/10.1080/20016689.2017.1299833 |
| work_keys_str_mv | AT acaban fillingthegapincnsdrugdevelopmentevaluationoftheroleofdrugrepurposing AT kpisarczyk fillingthegapincnsdrugdevelopmentevaluationoftheroleofdrugrepurposing AT kkopacz fillingthegapincnsdrugdevelopmentevaluationoftheroleofdrugrepurposing AT akapusniak fillingthegapincnsdrugdevelopmentevaluationoftheroleofdrugrepurposing AT mtoumi fillingthegapincnsdrugdevelopmentevaluationoftheroleofdrugrepurposing AT cremuzat fillingthegapincnsdrugdevelopmentevaluationoftheroleofdrugrepurposing AT akornfeld fillingthegapincnsdrugdevelopmentevaluationoftheroleofdrugrepurposing |