Validation of a HPLC-UV analytical and bioanalytical method for dexamethasone determination in nanoemulsions, porcine nasal mucosa, and mouse plasma and brain tissue

Validation of a HPLC-UV analytical and bioanalytical method for dexamethasone determination in nanoemulsions, porcine nasal mucosa, and mouse plasma and brain tissue

Dexamethasone (DEX) is a synthetic glucocorticoid widely used in the treatment of inflammatory and autoimmune diseases. However, its clinical efficacy is limited by low water solubility, poor bioavailability, and a high incidence of side effects. To overcome these limitations, nanotechnology-based...

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Main Authors: Luísa Degrandi Sehn, Gabriela Fusinatto de Oliveira, Melaine Maiara da Silva Lopes, Helder Ferreira Teixeira, Ursula da Silveira Matte, Roselena Silvestri Schuh, Flavia Fachel
Format: Article
Language:English
Published: Universidade Federal do Rio Grande do Sul 2025-07-01
Series:Drug Analytical Research
Subjects:
Dexamethasone
HPLC
nanotechnology
biological matrices
nasal
plasma
Online Access:https://seer.ufrgs.br/index.php/dar/article/view/148019
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