Predictive model for meningitis after pituitary tumor resection by endoscopic nasal trans-sphenoidal sinus approach

Abstract Background Meningitis is a significant complication following nasal trans-sphenoidal surgery for pituitary tumor resection. Meningitis increases hospital stays and costs, posing a burden to both patients and healthcare systems. This study aimed to develop a perioperative predictive model fo...

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Main Authors: Peiyun Zhou, Jianan Shi, Zongke Long, Bingyan Zhang, Wenran Qu, Huimin Wei, Simeng Zhang, Xiaorong Luan
Format: Article
Language:English
Published: BMC 2025-08-01
Series:European Journal of Medical Research
Subjects:
Online Access:https://doi.org/10.1186/s40001-025-03016-1
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author Peiyun Zhou
Jianan Shi
Zongke Long
Bingyan Zhang
Wenran Qu
Huimin Wei
Simeng Zhang
Xiaorong Luan
author_facet Peiyun Zhou
Jianan Shi
Zongke Long
Bingyan Zhang
Wenran Qu
Huimin Wei
Simeng Zhang
Xiaorong Luan
author_sort Peiyun Zhou
collection DOAJ
description Abstract Background Meningitis is a significant complication following nasal trans-sphenoidal surgery for pituitary tumor resection. Meningitis increases hospital stays and costs, posing a burden to both patients and healthcare systems. This study aimed to develop a perioperative predictive model for meningitis based on key factors, such as the operation duration, tumor diameter, and intraoperative cerebrospinal fluid (CSF) leakage. Methods A retrospective analysis was conducted on patients undergoing pituitary tumor resection via the nasal trans-sphenoidal approach. Predictive factors for meningitis, including operation duration, tumor diameter, and intraoperative CSF leakage, were analyzed. The model's predictive efficacy was evaluated using the collected data. Results Meningitis occurred in 8.7% of cases (35/401). Intraoperative CSF leakage, observed in 24.2% of cases, significantly increased the risk of infection. The tumor diameter was also linked to higher infection rates. The constructed model demonstrated good predictive performance, allowing for early risk identification. Conclusions This study developed a predictive model for Meningitis after pituitary tumor resection using the operation duration, tumor diameter, and CSF leakage. The model provides healthcare professionals with an effective tool to assess infection risk and implement timely intervention strategies to improve patient outcomes. Graphical Abstract
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series European Journal of Medical Research
spelling doaj-art-c3de21f2673649f4adfcd6f71f2f48242025-08-20T03:04:26ZengBMCEuropean Journal of Medical Research2047-783X2025-08-0130111010.1186/s40001-025-03016-1Predictive model for meningitis after pituitary tumor resection by endoscopic nasal trans-sphenoidal sinus approachPeiyun Zhou0Jianan Shi1Zongke Long2Bingyan Zhang3Wenran Qu4Huimin Wei5Simeng Zhang6Xiaorong Luan7School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong UniversitySchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong UniversitySchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong UniversitySchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong UniversitySchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong UniversitySchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong UniversitySchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong UniversitySchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong UniversityAbstract Background Meningitis is a significant complication following nasal trans-sphenoidal surgery for pituitary tumor resection. Meningitis increases hospital stays and costs, posing a burden to both patients and healthcare systems. This study aimed to develop a perioperative predictive model for meningitis based on key factors, such as the operation duration, tumor diameter, and intraoperative cerebrospinal fluid (CSF) leakage. Methods A retrospective analysis was conducted on patients undergoing pituitary tumor resection via the nasal trans-sphenoidal approach. Predictive factors for meningitis, including operation duration, tumor diameter, and intraoperative CSF leakage, were analyzed. The model's predictive efficacy was evaluated using the collected data. Results Meningitis occurred in 8.7% of cases (35/401). Intraoperative CSF leakage, observed in 24.2% of cases, significantly increased the risk of infection. The tumor diameter was also linked to higher infection rates. The constructed model demonstrated good predictive performance, allowing for early risk identification. Conclusions This study developed a predictive model for Meningitis after pituitary tumor resection using the operation duration, tumor diameter, and CSF leakage. The model provides healthcare professionals with an effective tool to assess infection risk and implement timely intervention strategies to improve patient outcomes. Graphical Abstracthttps://doi.org/10.1186/s40001-025-03016-1MeningitisPituitary tumorNasal trans-sphenoidal surgeryPituitary adenomasAntimicrobial drugIntracranial tumor
spellingShingle Peiyun Zhou
Jianan Shi
Zongke Long
Bingyan Zhang
Wenran Qu
Huimin Wei
Simeng Zhang
Xiaorong Luan
Predictive model for meningitis after pituitary tumor resection by endoscopic nasal trans-sphenoidal sinus approach
European Journal of Medical Research
Meningitis
Pituitary tumor
Nasal trans-sphenoidal surgery
Pituitary adenomas
Antimicrobial drug
Intracranial tumor
title Predictive model for meningitis after pituitary tumor resection by endoscopic nasal trans-sphenoidal sinus approach
title_full Predictive model for meningitis after pituitary tumor resection by endoscopic nasal trans-sphenoidal sinus approach
title_fullStr Predictive model for meningitis after pituitary tumor resection by endoscopic nasal trans-sphenoidal sinus approach
title_full_unstemmed Predictive model for meningitis after pituitary tumor resection by endoscopic nasal trans-sphenoidal sinus approach
title_short Predictive model for meningitis after pituitary tumor resection by endoscopic nasal trans-sphenoidal sinus approach
title_sort predictive model for meningitis after pituitary tumor resection by endoscopic nasal trans sphenoidal sinus approach
topic Meningitis
Pituitary tumor
Nasal trans-sphenoidal surgery
Pituitary adenomas
Antimicrobial drug
Intracranial tumor
url https://doi.org/10.1186/s40001-025-03016-1
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