Improving adherence and clinical outcomes in self-guided internet treatment for anxiety and depression: randomised controlled trial.

<h4>Background</h4>Depression and anxiety are common, disabling and chronic. Self-guided internet-delivered treatments are popular, but few people complete them. New strategies are required to realise their potential.<h4>Aims</h4>To evaluate the effect of automated emails on...

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Main Authors: Nickolai Titov, Blake F Dear, Luke Johnston, Carolyn Lorian, Judy Zou, Bethany Wootton, Jay Spence, Peter M McEvoy, Ronald M Rapee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0062873&type=printable
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Summary:<h4>Background</h4>Depression and anxiety are common, disabling and chronic. Self-guided internet-delivered treatments are popular, but few people complete them. New strategies are required to realise their potential.<h4>Aims</h4>To evaluate the effect of automated emails on the effectiveness, safety, and acceptability of a new automated transdiagnostic self-guided internet-delivered treatment, the Wellbeing Course, for people with depression and anxiety.<h4>Method</h4>A randomised controlled trial was conducted through the website: www.ecentreclinic.org. Two hundred and fifty seven people with elevated symptoms were randomly allocated to the 8 week course either with or without automated emails, or to a waitlist control group. Primary outcome measures were the Patient Health Questionnaire 9-Item (PHQ-9) and the Generalized Anxiety Disorder 7-Item (GAD-7).<h4>Results</h4>Participants in the treatment groups had lower PHQ-9 and GAD-7 scores at post-treatment than controls. Automated emails increased rates of course completion (58% vs. 35%), and improved outcomes in a subsample with elevated symptoms.<h4>Conclusions</h4>The new self-guided course was beneficial, and automated emails facilitated outcomes. Further attention to strategies that facilitate adherence, learning, and safety will help realise the potential of self-guided interventions.<h4>Trial registration</h4>Australian and New Zealand Clinical Trials Registry ACTRN12610001058066.
ISSN:1932-6203