Sex and region-specific disruption of autophagy and mitophagy in Alzheimer’s disease: linking cellular dysfunction to cognitive decline

Sex and region-specific disruption of autophagy and mitophagy in Alzheimer’s disease: linking cellular dysfunction to cognitive decline

Abstract Macroautophagy and mitophagy are critical processes in Alzheimer’s disease (AD), yet their links to behavioral outcomes, particularly sex-specific differences, are not fully understood. This study investigates autophagic (LC3B-II, SQSTM1) and mitophagic (BNIP3L, BNIP3, BCL2L13) markers in t...

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Main Authors: Aida Adlimoghaddam, Fariba Fayazbakhsh, Mohsen Mohammadi, Zeinab Babaei, Amir Barzegar Behrooz, Farhad Tabasi, Teng Guan, Iman Beheshti, Mahmoud Aghaei, Daniel J. Klionsky, Benedict C. Albensi, Saeid Ghavami
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02490-0
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