Comparison of the proteomic landscape in experimental ischemia reperfusion with versus without ischemic preconditioning

Comparison of the proteomic landscape in experimental ischemia reperfusion with versus without ischemic preconditioning

Abstract Myocardial ischemic preconditioning (IPC) enhances myocardial resilience to ischemic injury. Myocardial stunning is a transient, reversible dysfunction, while necrosis involves irreversible cell death. The relationship between IPC, stunning, and necrosis is not well understood, requiring fu...

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Main Authors: Yalda Kakaei, Shafaat Hussain, Ahmed Elmahdy, Evelin Berger, Aaron Shekka Espinosa, Valentyna Sevastianova, Zahra Sheybani, Amin Al-Awar, Mana Kalani, Sandeep Jha, Ermir Zulfaj, Amirali Nejat, Abhishek Jha, Tetiana Pylova, Maryna Krasnikova, Erik Axel Andersson, Vagner Ramon Rodrigues Silva, Elmir Omerovic, Björn Redfors
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Myocardial ischemic preconditioning
Myocardial stunning
Myocardial infarction
Cardiac proteomics
Ischemia-reperfusion injury
Therapeutic targets
Online Access:https://doi.org/10.1038/s41598-025-90735-4
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