Combined hyperthermia and radiotherapy for prostate cancer: a systematic review
Optimization of treatment strategies for prostate cancer patients treated with curative radiation therapy (RT) represents one of the major challenges for the radiation oncologist. Dose escalation or combination of RT with systemic therapies is used to improve tumor control in patients with unfavorab...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2022.2053212 |
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| author | Jennifer Le Guevelou Monica Emilia Chirila Vérane Achard Pauline Coralie Guillemin Orane Lorton Johannes W. E. Uiterwijk Giovanna Dipasquale Rares Salomir Thomas Zilli |
| author_facet | Jennifer Le Guevelou Monica Emilia Chirila Vérane Achard Pauline Coralie Guillemin Orane Lorton Johannes W. E. Uiterwijk Giovanna Dipasquale Rares Salomir Thomas Zilli |
| author_sort | Jennifer Le Guevelou |
| collection | DOAJ |
| description | Optimization of treatment strategies for prostate cancer patients treated with curative radiation therapy (RT) represents one of the major challenges for the radiation oncologist. Dose escalation or combination of RT with systemic therapies is used to improve tumor control in patients with unfavorable prostate cancer, at the risk of increasing rates and severity of treatment-related toxicities. Elevation of temperature to a supra-physiological level has been shown to both increase tumor oxygenation and reduce DNA repair capabilities. Thus, hyperthermia (HT) combined with RT represents a compelling treatment strategy to improve the therapeutic ratio in prostate cancer patients. The aim of the present systematic review is to report on preclinical and clinical evidence supporting the combination of HT and RT for prostate cancer, discussing future applications and developments of this combined treatment. |
| format | Article |
| id | doaj-art-c3cff2b0c4e2426ebd5345735c2f191b |
| institution | DOAJ |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-c3cff2b0c4e2426ebd5345735c2f191b2025-08-20T02:40:42ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572022-12-0139154755610.1080/02656736.2022.2053212Combined hyperthermia and radiotherapy for prostate cancer: a systematic reviewJennifer Le Guevelou0Monica Emilia Chirila1Vérane Achard2Pauline Coralie Guillemin3Orane Lorton4Johannes W. E. Uiterwijk5Giovanna Dipasquale6Rares Salomir7Thomas Zilli8Division of Radiation Oncology, Geneva University Hospital, Geneva, SwitzerlandDivision of Radiation Oncology, Geneva University Hospital, Geneva, SwitzerlandDivision of Radiation Oncology, Geneva University Hospital, Geneva, SwitzerlandDepartment of Radiology and Medical Informatics, Geneva University Hospital, Geneva, SwitzerlandDepartment of Radiology and Medical Informatics, Geneva University Hospital, Geneva, SwitzerlandFaculty of Medicine, Geneva University, Geneva, SwitzerlandDivision of Radiation Oncology, Geneva University Hospital, Geneva, SwitzerlandFaculty of Medicine, Geneva University, Geneva, SwitzerlandDivision of Radiation Oncology, Geneva University Hospital, Geneva, SwitzerlandOptimization of treatment strategies for prostate cancer patients treated with curative radiation therapy (RT) represents one of the major challenges for the radiation oncologist. Dose escalation or combination of RT with systemic therapies is used to improve tumor control in patients with unfavorable prostate cancer, at the risk of increasing rates and severity of treatment-related toxicities. Elevation of temperature to a supra-physiological level has been shown to both increase tumor oxygenation and reduce DNA repair capabilities. Thus, hyperthermia (HT) combined with RT represents a compelling treatment strategy to improve the therapeutic ratio in prostate cancer patients. The aim of the present systematic review is to report on preclinical and clinical evidence supporting the combination of HT and RT for prostate cancer, discussing future applications and developments of this combined treatment.https://www.tandfonline.com/doi/10.1080/02656736.2022.2053212Prostate cancerradiotherapyhyperthermiatoxicityrecurrence |
| spellingShingle | Jennifer Le Guevelou Monica Emilia Chirila Vérane Achard Pauline Coralie Guillemin Orane Lorton Johannes W. E. Uiterwijk Giovanna Dipasquale Rares Salomir Thomas Zilli Combined hyperthermia and radiotherapy for prostate cancer: a systematic review International Journal of Hyperthermia Prostate cancer radiotherapy hyperthermia toxicity recurrence |
| title | Combined hyperthermia and radiotherapy for prostate cancer: a systematic review |
| title_full | Combined hyperthermia and radiotherapy for prostate cancer: a systematic review |
| title_fullStr | Combined hyperthermia and radiotherapy for prostate cancer: a systematic review |
| title_full_unstemmed | Combined hyperthermia and radiotherapy for prostate cancer: a systematic review |
| title_short | Combined hyperthermia and radiotherapy for prostate cancer: a systematic review |
| title_sort | combined hyperthermia and radiotherapy for prostate cancer a systematic review |
| topic | Prostate cancer radiotherapy hyperthermia toxicity recurrence |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2022.2053212 |
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