Changes of hemostatic factors in patients with hemoglobinopathies
In this study, protein C (PC), protein S (PS), heparin cofactor II (HCFII), prothrombin fragment 1+2(PF1,2), thrombin-antithrombin III complex (TAT), von Willebrand factor (vWF) and thrombomodulin (TM) were investigated in 13 patients with beta thalassemia intermedia (TI) not requiring transf...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
1999-07-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/3239 |
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| _version_ | 1850033425406230528 |
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| author | A F Oner A Gürgey H Okur S Kirazli F Gümrük C Altay |
| author_facet | A F Oner A Gürgey H Okur S Kirazli F Gümrük C Altay |
| author_sort | A F Oner |
| collection | DOAJ |
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In this study, protein C (PC), protein S (PS), heparin cofactor II (HCFII), prothrombin fragment 1+2(PF1,2), thrombin-antithrombin III complex (TAT), von Willebrand factor (vWF) and thrombomodulin (TM) were investigated in 13 patients with beta thalassemia intermedia (TI) not requiring transfusion, six patients with sickle cell disease (SCD), and seven patients with HbS-beta thalassemia (S-BT) who were not in crisis. These hemostatic parameters were also studied in 12 healthy children assigned as a control group. Protein C and Protein S (PC-PS) were found to be decreased in TI patients and normal in S-BT patients. PC was decreased in SCD patients. In the patients with TI and SCD, the mean PF1,2 level was elevated, whereas the TAT level was not statistically different from that of the control group. These results suggested that in patients with hemoglobinopathies: a) decreased natural anticoagulants and b) enhanced procoagulant activation have been encountered. Other unexpected and interesting results of this study are the decreased vWF and elevated HCFII levels in all three patient groups.
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| format | Article |
| id | doaj-art-c3b0ea4b8b4c4af8af533cb0886ff842 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 1999-07-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-c3b0ea4b8b4c4af8af533cb0886ff8422025-08-20T02:58:14ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64211999-07-01413Changes of hemostatic factors in patients with hemoglobinopathiesA F Oner0A GürgeyH OkurS KirazliF GümrükC AltayDepartment of Pediatrics, Hacettepe University Faculty of Medicine, Ankara. In this study, protein C (PC), protein S (PS), heparin cofactor II (HCFII), prothrombin fragment 1+2(PF1,2), thrombin-antithrombin III complex (TAT), von Willebrand factor (vWF) and thrombomodulin (TM) were investigated in 13 patients with beta thalassemia intermedia (TI) not requiring transfusion, six patients with sickle cell disease (SCD), and seven patients with HbS-beta thalassemia (S-BT) who were not in crisis. These hemostatic parameters were also studied in 12 healthy children assigned as a control group. Protein C and Protein S (PC-PS) were found to be decreased in TI patients and normal in S-BT patients. PC was decreased in SCD patients. In the patients with TI and SCD, the mean PF1,2 level was elevated, whereas the TAT level was not statistically different from that of the control group. These results suggested that in patients with hemoglobinopathies: a) decreased natural anticoagulants and b) enhanced procoagulant activation have been encountered. Other unexpected and interesting results of this study are the decreased vWF and elevated HCFII levels in all three patient groups. https://turkjpediatr.org/article/view/3239 |
| spellingShingle | A F Oner A Gürgey H Okur S Kirazli F Gümrük C Altay Changes of hemostatic factors in patients with hemoglobinopathies The Turkish Journal of Pediatrics |
| title | Changes of hemostatic factors in patients with hemoglobinopathies |
| title_full | Changes of hemostatic factors in patients with hemoglobinopathies |
| title_fullStr | Changes of hemostatic factors in patients with hemoglobinopathies |
| title_full_unstemmed | Changes of hemostatic factors in patients with hemoglobinopathies |
| title_short | Changes of hemostatic factors in patients with hemoglobinopathies |
| title_sort | changes of hemostatic factors in patients with hemoglobinopathies |
| url | https://turkjpediatr.org/article/view/3239 |
| work_keys_str_mv | AT afoner changesofhemostaticfactorsinpatientswithhemoglobinopathies AT agurgey changesofhemostaticfactorsinpatientswithhemoglobinopathies AT hokur changesofhemostaticfactorsinpatientswithhemoglobinopathies AT skirazli changesofhemostaticfactorsinpatientswithhemoglobinopathies AT fgumruk changesofhemostaticfactorsinpatientswithhemoglobinopathies AT caltay changesofhemostaticfactorsinpatientswithhemoglobinopathies |