Traumatic Brain Injury and Substance Related Disorder: A 10-Year Nationwide Cohort Study in Taiwan
Whether traumatic brain injury (TBI) is causally related to substance related disorder (SRD) is still debatable, especially in persons with no history of mental disorders at the time of injury. This study analyzed data in the Taiwan National Health Insurance Research Database for 19,109 patients age...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/8030676 |
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| author | Chieh-Hsin Wu Tai-Hsin Tsai Yu-Feng Su Zi-Hao Zhang Wei Liu Ming-Kung Wu Chih-Hui Chang Keng-Liang Kuo Ying-Yi Lu Chih-Lung Lin |
| author_facet | Chieh-Hsin Wu Tai-Hsin Tsai Yu-Feng Su Zi-Hao Zhang Wei Liu Ming-Kung Wu Chih-Hui Chang Keng-Liang Kuo Ying-Yi Lu Chih-Lung Lin |
| author_sort | Chieh-Hsin Wu |
| collection | DOAJ |
| description | Whether traumatic brain injury (TBI) is causally related to substance related disorder (SRD) is still debatable, especially in persons with no history of mental disorders at the time of injury. This study analyzed data in the Taiwan National Health Insurance Research Database for 19,109 patients aged ≥18 years who had been diagnosed with TBI during 2000–2010. An additional 19,109 randomly selected age and gender matched patients without TBI (1 : 1 ratio) were enrolled in the control group. The relationship between TBI and SRD was estimated with Cox proportional hazard regression models. During the follow-up period, SRD developed in 340 patients in the TBI group and in 118 patients in the control group. After controlling for covariates, the overall incidence of SRD was 3.62-fold higher in the TBI group compared to the control group. Additionally, patients in the severe TBI subgroup were 9.01 times more likely to have SRD compared to controls. Notably, patients in the TBI group were prone to alcohol related disorders. The data in this study indicate that TBI is significantly associated with the subsequent risk of SRD. Physicians treating patients with TBI should be alert to this association to prevent the occurrence of adverse events. |
| format | Article |
| id | doaj-art-c3acd5d950d149f6881a2493411828cd |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-c3acd5d950d149f6881a2493411828cd2025-08-20T02:18:56ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/80306768030676Traumatic Brain Injury and Substance Related Disorder: A 10-Year Nationwide Cohort Study in TaiwanChieh-Hsin Wu0Tai-Hsin Tsai1Yu-Feng Su2Zi-Hao Zhang3Wei Liu4Ming-Kung Wu5Chih-Hui Chang6Keng-Liang Kuo7Ying-Yi Lu8Chih-Lung Lin9Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Neurosurgery, The No. 7 People’s Hospital of Hebei Province, Dingzhou, Hebei 073000, ChinaDepartment of Neurosurgery, Yucheng People’s Hospital, Yucheng, Shandong 251200, ChinaDepartment of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 807, TaiwanDepartment of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, TaiwanGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanWhether traumatic brain injury (TBI) is causally related to substance related disorder (SRD) is still debatable, especially in persons with no history of mental disorders at the time of injury. This study analyzed data in the Taiwan National Health Insurance Research Database for 19,109 patients aged ≥18 years who had been diagnosed with TBI during 2000–2010. An additional 19,109 randomly selected age and gender matched patients without TBI (1 : 1 ratio) were enrolled in the control group. The relationship between TBI and SRD was estimated with Cox proportional hazard regression models. During the follow-up period, SRD developed in 340 patients in the TBI group and in 118 patients in the control group. After controlling for covariates, the overall incidence of SRD was 3.62-fold higher in the TBI group compared to the control group. Additionally, patients in the severe TBI subgroup were 9.01 times more likely to have SRD compared to controls. Notably, patients in the TBI group were prone to alcohol related disorders. The data in this study indicate that TBI is significantly associated with the subsequent risk of SRD. Physicians treating patients with TBI should be alert to this association to prevent the occurrence of adverse events.http://dx.doi.org/10.1155/2016/8030676 |
| spellingShingle | Chieh-Hsin Wu Tai-Hsin Tsai Yu-Feng Su Zi-Hao Zhang Wei Liu Ming-Kung Wu Chih-Hui Chang Keng-Liang Kuo Ying-Yi Lu Chih-Lung Lin Traumatic Brain Injury and Substance Related Disorder: A 10-Year Nationwide Cohort Study in Taiwan Neural Plasticity |
| title | Traumatic Brain Injury and Substance Related Disorder: A 10-Year Nationwide Cohort Study in Taiwan |
| title_full | Traumatic Brain Injury and Substance Related Disorder: A 10-Year Nationwide Cohort Study in Taiwan |
| title_fullStr | Traumatic Brain Injury and Substance Related Disorder: A 10-Year Nationwide Cohort Study in Taiwan |
| title_full_unstemmed | Traumatic Brain Injury and Substance Related Disorder: A 10-Year Nationwide Cohort Study in Taiwan |
| title_short | Traumatic Brain Injury and Substance Related Disorder: A 10-Year Nationwide Cohort Study in Taiwan |
| title_sort | traumatic brain injury and substance related disorder a 10 year nationwide cohort study in taiwan |
| url | http://dx.doi.org/10.1155/2016/8030676 |
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