An observational study comparing two regimens of PGE2 gel for pre-induction cervical ripening at term
Objectives: The objective of this study was to compare the outcome in between two groups, one group receiving a 6 hourly repeat regimen (maximum 2 such) and another group receiving a 12 hourly repeat regimen of prostaglandin E 2 gel (maximum 2 such) for pre-induction cervical ripening. Methods: In...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Barpeta Obstetrics and Gynaecological Society
2024-12-01
|
| Series: | New Indian Journal of OBGYN |
| Subjects: | |
| Online Access: | https://journal.barpetaogs.co.in/pdf/111131.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850187113396436992 |
|---|---|
| author | Nishat Parveen Begg Shelley Seth Aparna Khan Mandal |
| author_facet | Nishat Parveen Begg Shelley Seth Aparna Khan Mandal |
| author_sort | Nishat Parveen Begg |
| collection | DOAJ |
| description | Objectives: The objective of this study was to compare the outcome in between two groups, one group receiving a 6
hourly repeat regimen (maximum 2 such) and another group receiving a 12 hourly repeat regimen of prostaglandin E
2 gel (maximum 2 such) for pre-induction cervical ripening. Methods: In this observational cross sectional analytical
study, pregnant mothers with singleton pregnancy, viable foetus at 37-42 weeks gestational age receiving either
repeated doses of prostaglandin E2 gel 0.5 mg every 6 hours or every 12 hours for maximum 2 times were selected
matching their baseline characteristics. Mode of delivery and feto-maternal outcome were assessed. The sample size
was 114 in each group. Results: More patients are delivering with a single dose of Prostaglandin E2 gel in the 12
hourly repeat group (24.56% in the 6 hourly group versus 30.7% in the 12 hourly group, p value = 0.2998). More
patients are delivering vaginally in the 12 hourly repeat group (76.3% in the 6 hourly group versus 82.5% in the 12
hourly group, p = 0.2518). There is lesser number of neonatal and maternal complications with the 12 hourly repeat
groups. But none of these results are statistically significant. Conclusion: Repeating prostaglandin E2 gel 12 hourly is
as effective as repeating it 6 hourly, rather the 12 hourly regimen has lesser neonatal and maternal complications and
is more cost effective although studies on greater population is needed to make these results statistically significant. |
| format | Article |
| id | doaj-art-c3a7e5ad7c4a49a18e5018ae3f33d30e |
| institution | OA Journals |
| issn | 2454-2334 2454-2342 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Barpeta Obstetrics and Gynaecological Society |
| record_format | Article |
| series | New Indian Journal of OBGYN |
| spelling | doaj-art-c3a7e5ad7c4a49a18e5018ae3f33d30e2025-08-20T02:16:10ZengBarpeta Obstetrics and Gynaecological SocietyNew Indian Journal of OBGYN2454-23342454-23422024-12-0111113113410.21276/obgyn.20252024.11.1.24An observational study comparing two regimens of PGE2 gel for pre-induction cervical ripening at termNishat Parveen Begg0 Shelley Seth1Aparna Khan Mandal2Senior Resident, Department of Obstetrics and Gynaecology, Rampurhat Govrnment Medical college and HospitalAssociate Professor, Department of Obstetrics and Gynaecology, RG Kar Medical College and HospitalAssociate Professor, Department of Obstetrics and Gynaecology, R G Kar Medical College and HospitalObjectives: The objective of this study was to compare the outcome in between two groups, one group receiving a 6 hourly repeat regimen (maximum 2 such) and another group receiving a 12 hourly repeat regimen of prostaglandin E 2 gel (maximum 2 such) for pre-induction cervical ripening. Methods: In this observational cross sectional analytical study, pregnant mothers with singleton pregnancy, viable foetus at 37-42 weeks gestational age receiving either repeated doses of prostaglandin E2 gel 0.5 mg every 6 hours or every 12 hours for maximum 2 times were selected matching their baseline characteristics. Mode of delivery and feto-maternal outcome were assessed. The sample size was 114 in each group. Results: More patients are delivering with a single dose of Prostaglandin E2 gel in the 12 hourly repeat group (24.56% in the 6 hourly group versus 30.7% in the 12 hourly group, p value = 0.2998). More patients are delivering vaginally in the 12 hourly repeat group (76.3% in the 6 hourly group versus 82.5% in the 12 hourly group, p = 0.2518). There is lesser number of neonatal and maternal complications with the 12 hourly repeat groups. But none of these results are statistically significant. Conclusion: Repeating prostaglandin E2 gel 12 hourly is as effective as repeating it 6 hourly, rather the 12 hourly regimen has lesser neonatal and maternal complications and is more cost effective although studies on greater population is needed to make these results statistically significant.https://journal.barpetaogs.co.in/pdf/111131.pdfprostaglandin e2 gel6 hourly group12 hourly group |
| spellingShingle | Nishat Parveen Begg Shelley Seth Aparna Khan Mandal An observational study comparing two regimens of PGE2 gel for pre-induction cervical ripening at term New Indian Journal of OBGYN prostaglandin e2 gel 6 hourly group 12 hourly group |
| title | An observational study comparing two regimens of PGE2 gel for pre-induction cervical ripening at term |
| title_full | An observational study comparing two regimens of PGE2 gel for pre-induction cervical ripening at term |
| title_fullStr | An observational study comparing two regimens of PGE2 gel for pre-induction cervical ripening at term |
| title_full_unstemmed | An observational study comparing two regimens of PGE2 gel for pre-induction cervical ripening at term |
| title_short | An observational study comparing two regimens of PGE2 gel for pre-induction cervical ripening at term |
| title_sort | observational study comparing two regimens of pge2 gel for pre induction cervical ripening at term |
| topic | prostaglandin e2 gel 6 hourly group 12 hourly group |
| url | https://journal.barpetaogs.co.in/pdf/111131.pdf |
| work_keys_str_mv | AT nishatparveenbegg anobservationalstudycomparingtworegimensofpge2gelforpreinductioncervicalripeningatterm AT shelleyseth anobservationalstudycomparingtworegimensofpge2gelforpreinductioncervicalripeningatterm AT aparnakhanmandal anobservationalstudycomparingtworegimensofpge2gelforpreinductioncervicalripeningatterm AT nishatparveenbegg observationalstudycomparingtworegimensofpge2gelforpreinductioncervicalripeningatterm AT shelleyseth observationalstudycomparingtworegimensofpge2gelforpreinductioncervicalripeningatterm AT aparnakhanmandal observationalstudycomparingtworegimensofpge2gelforpreinductioncervicalripeningatterm |