Unlocking the dual healing powers of plant-based metallic nanoparticles: managing diabetes and tackling male infertility challenges
Diabetes mellitus (DM) is a severe metabolic disorder characterized by an increase in blood glucose level due to insufficient insulin production or failure of insulin action on targeted tissues or both. DM impacts male reproductive health across four aspects: ejaculation, erectile dysfunction, struc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1482127/full |
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| author | Ayesha Siddiqa Rahmatullah Qureshi Ghazala Yasmin Shaista Rafique Noor-Ul-Ain Zafar Chudary Sadam Hussain Sana ur Rehman Neelum Naheed |
| author_facet | Ayesha Siddiqa Rahmatullah Qureshi Ghazala Yasmin Shaista Rafique Noor-Ul-Ain Zafar Chudary Sadam Hussain Sana ur Rehman Neelum Naheed |
| author_sort | Ayesha Siddiqa |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a severe metabolic disorder characterized by an increase in blood glucose level due to insufficient insulin production or failure of insulin action on targeted tissues or both. DM impacts male reproductive health across four aspects: ejaculation, erectile dysfunction, structural alterations in reproductive organs, and alterations in semen quality. The population of male individuals with diabetes is steadily rising, paralleled by an increase in fertility issues among men. A WHO report states that diabetes mellitus affects about 171 million (2.8%) persons worldwide. Anti-diabetic medications that are now on the market are expensive and have several negative effects, including cardiac, hepatic, and renal failure in diabetic patients. Keeping in view, this review emphasizes the limitations of currently used synthetic anti-diabetic drugs and provides the progress in the development of phytogenic metallic NPs (NP)in the treatment of diabetes and associated male infertility. To collect data, various databases were examined, including Springer Link, Google Scholar, PubMed, Wiley Online Library, and Science Direct. Several studies and research reports based on nanotechnological approaches in the formulation of anti-diabetic drugs have pointed out the fact that research in the formulation of nanodrugs has improved strategies for combating diabetes and associated male infertility based on the plausible molecular mechanism of action of the drugs. These nanodrugs have been observed to significantly influence regulatory mechanisms through their effects on pancreatic α-amylase, intestinal α-glucosidase, insulin action, and glucose uptake across various in vivo and in vitro systems. Moreover, integrating nanotechnological methodologies with the exploration of herbal compounds further enhances the understanding of their chemical potential. This synergistic approach may pave the way for identifying novel drug candidates with exceptional therapeutic efficacy, offering significant advantages in the management of diabetes and associated male infertility for the betterment of humanity. Furthermore, the personalized design of plant-based metallic NPs has the potential to significantly advance precision medicine techniques for the treatment of male infertility and diabetes. |
| format | Article |
| id | doaj-art-c3a1c60e067e4e2592b7d0e4f2170f30 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-c3a1c60e067e4e2592b7d0e4f2170f302025-08-20T03:29:30ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-07-011610.3389/fendo.2025.14821271482127Unlocking the dual healing powers of plant-based metallic nanoparticles: managing diabetes and tackling male infertility challengesAyesha Siddiqa0Rahmatullah Qureshi1Ghazala Yasmin2Shaista Rafique3Noor-Ul-Ain Zafar4Chudary Sadam Hussain5Sana ur Rehman6Neelum Naheed7Department of Botany, Pir Mehr Ali Shah-Arid Agriculture University, Rawalpindi, PakistanDepartment of Botany, Pir Mehr Ali Shah-Arid Agriculture University, Rawalpindi, PakistanDepartment of Botany, Government Graduate College for Women, Jhelum, PakistanDepartment of Botany, Pir Mehr Ali Shah-Arid Agriculture University, Rawalpindi, PakistanDepartment of Botany, Pir Mehr Ali Shah-Arid Agriculture University, Rawalpindi, PakistanDepartment of Botany, Pir Mehr Ali Shah-Arid Agriculture University, Rawalpindi, PakistanNational Research Center of Intercropping, The Islamia University of Bahawalpur, Bahawalpur, PakistanDepartment of Botany, Pir Mehr Ali Shah-Arid Agriculture University, Rawalpindi, PakistanDiabetes mellitus (DM) is a severe metabolic disorder characterized by an increase in blood glucose level due to insufficient insulin production or failure of insulin action on targeted tissues or both. DM impacts male reproductive health across four aspects: ejaculation, erectile dysfunction, structural alterations in reproductive organs, and alterations in semen quality. The population of male individuals with diabetes is steadily rising, paralleled by an increase in fertility issues among men. A WHO report states that diabetes mellitus affects about 171 million (2.8%) persons worldwide. Anti-diabetic medications that are now on the market are expensive and have several negative effects, including cardiac, hepatic, and renal failure in diabetic patients. Keeping in view, this review emphasizes the limitations of currently used synthetic anti-diabetic drugs and provides the progress in the development of phytogenic metallic NPs (NP)in the treatment of diabetes and associated male infertility. To collect data, various databases were examined, including Springer Link, Google Scholar, PubMed, Wiley Online Library, and Science Direct. Several studies and research reports based on nanotechnological approaches in the formulation of anti-diabetic drugs have pointed out the fact that research in the formulation of nanodrugs has improved strategies for combating diabetes and associated male infertility based on the plausible molecular mechanism of action of the drugs. These nanodrugs have been observed to significantly influence regulatory mechanisms through their effects on pancreatic α-amylase, intestinal α-glucosidase, insulin action, and glucose uptake across various in vivo and in vitro systems. Moreover, integrating nanotechnological methodologies with the exploration of herbal compounds further enhances the understanding of their chemical potential. This synergistic approach may pave the way for identifying novel drug candidates with exceptional therapeutic efficacy, offering significant advantages in the management of diabetes and associated male infertility for the betterment of humanity. Furthermore, the personalized design of plant-based metallic NPs has the potential to significantly advance precision medicine techniques for the treatment of male infertility and diabetes.https://www.frontiersin.org/articles/10.3389/fendo.2025.1482127/fulldiabetes mellitusmale infertilitynanotechnologyanti-diabetic drugsphyto-nanoparticles |
| spellingShingle | Ayesha Siddiqa Rahmatullah Qureshi Ghazala Yasmin Shaista Rafique Noor-Ul-Ain Zafar Chudary Sadam Hussain Sana ur Rehman Neelum Naheed Unlocking the dual healing powers of plant-based metallic nanoparticles: managing diabetes and tackling male infertility challenges Frontiers in Endocrinology diabetes mellitus male infertility nanotechnology anti-diabetic drugs phyto-nanoparticles |
| title | Unlocking the dual healing powers of plant-based metallic nanoparticles: managing diabetes and tackling male infertility challenges |
| title_full | Unlocking the dual healing powers of plant-based metallic nanoparticles: managing diabetes and tackling male infertility challenges |
| title_fullStr | Unlocking the dual healing powers of plant-based metallic nanoparticles: managing diabetes and tackling male infertility challenges |
| title_full_unstemmed | Unlocking the dual healing powers of plant-based metallic nanoparticles: managing diabetes and tackling male infertility challenges |
| title_short | Unlocking the dual healing powers of plant-based metallic nanoparticles: managing diabetes and tackling male infertility challenges |
| title_sort | unlocking the dual healing powers of plant based metallic nanoparticles managing diabetes and tackling male infertility challenges |
| topic | diabetes mellitus male infertility nanotechnology anti-diabetic drugs phyto-nanoparticles |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1482127/full |
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