Association between VEGF gene polymorphisms and breast cancer risk
Introduction: Breast cancer (BC) poses a significant global health challenge. In Sudan, the absence of a national cancer registry has resulted in an underestimation of BC incidence. BC is notably the most common cancer among Sudanese women, especially affecting those under 50, with many cases diagno...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Biochemistry and Biophysics Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580825002894 |
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| author | Hala Osman Mozan Hassan Mohamed Alfaki Ghada Haj-Ali |
| author_facet | Hala Osman Mozan Hassan Mohamed Alfaki Ghada Haj-Ali |
| author_sort | Hala Osman |
| collection | DOAJ |
| description | Introduction: Breast cancer (BC) poses a significant global health challenge. In Sudan, the absence of a national cancer registry has resulted in an underestimation of BC incidence. BC is notably the most common cancer among Sudanese women, especially affecting those under 50, with many cases diagnosed at advanced stages. Angiogenesis, driven by vascular endothelial growth factor (VEGF), plays a critical role in the progression and recurrence of BC. This study examines the relationship between the VEGF (rs699947) gene polymorphism and BC among Sudanese women in Khartoum State in 2022. Methodology: A case-control study was conducted with 30 BC patients, and tissue samples were collected for molecular analysis. DNA was extracted and genotyped for the VEGF (rs699947) polymorphism using allele-specific PCR. Results: No statistically significant association was found between the VEGF-2578 C > A polymorphism and BC risk in our study population. Although the A allele was more prevalent in tumor tissues compared to normal tissues, with no significant correlation with tumor stage or grade. The study revealed that BC in Sudanese women often presents at younger ages and is predominantly invasive ductal carcinoma, with stage II being the most common. Conclusion: These findings emphasize the necessity for continued research to explore additional genetic factors and improve our understanding of BC and associated risks. Advancing early detection and prevention methods is vital, particularly for underrepresented populations. However, the small sample size in this study may limit the statistical power to detect significant associations, and thus, findings should be interpreted with caution. |
| format | Article |
| id | doaj-art-c3a1a0614edb4ac2a14f7a4e0f466240 |
| institution | Kabale University |
| issn | 2405-5808 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj-art-c3a1a0614edb4ac2a14f7a4e0f4662402025-08-20T03:41:54ZengElsevierBiochemistry and Biophysics Reports2405-58082025-09-014310220210.1016/j.bbrep.2025.102202Association between VEGF gene polymorphisms and breast cancer riskHala Osman0Mozan Hassan1Mohamed Alfaki2Ghada Haj-Ali3Al Neelain Medical Research Center, Faculty of Medicine, Al Neelain University, Khartoum, Sudan; Corresponding author.Faculty of Medical Laboratory Science, Omdurman Ahlia University, Khartoum, Sudan; Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab EmiratesFaculty of Computer Science, Al Neelain University, Khartoum, SudanAl Neelain Medical Research Center, Faculty of Medicine, Al Neelain University, Khartoum, SudanIntroduction: Breast cancer (BC) poses a significant global health challenge. In Sudan, the absence of a national cancer registry has resulted in an underestimation of BC incidence. BC is notably the most common cancer among Sudanese women, especially affecting those under 50, with many cases diagnosed at advanced stages. Angiogenesis, driven by vascular endothelial growth factor (VEGF), plays a critical role in the progression and recurrence of BC. This study examines the relationship between the VEGF (rs699947) gene polymorphism and BC among Sudanese women in Khartoum State in 2022. Methodology: A case-control study was conducted with 30 BC patients, and tissue samples were collected for molecular analysis. DNA was extracted and genotyped for the VEGF (rs699947) polymorphism using allele-specific PCR. Results: No statistically significant association was found between the VEGF-2578 C > A polymorphism and BC risk in our study population. Although the A allele was more prevalent in tumor tissues compared to normal tissues, with no significant correlation with tumor stage or grade. The study revealed that BC in Sudanese women often presents at younger ages and is predominantly invasive ductal carcinoma, with stage II being the most common. Conclusion: These findings emphasize the necessity for continued research to explore additional genetic factors and improve our understanding of BC and associated risks. Advancing early detection and prevention methods is vital, particularly for underrepresented populations. However, the small sample size in this study may limit the statistical power to detect significant associations, and thus, findings should be interpreted with caution.http://www.sciencedirect.com/science/article/pii/S2405580825002894 |
| spellingShingle | Hala Osman Mozan Hassan Mohamed Alfaki Ghada Haj-Ali Association between VEGF gene polymorphisms and breast cancer risk Biochemistry and Biophysics Reports |
| title | Association between VEGF gene polymorphisms and breast cancer risk |
| title_full | Association between VEGF gene polymorphisms and breast cancer risk |
| title_fullStr | Association between VEGF gene polymorphisms and breast cancer risk |
| title_full_unstemmed | Association between VEGF gene polymorphisms and breast cancer risk |
| title_short | Association between VEGF gene polymorphisms and breast cancer risk |
| title_sort | association between vegf gene polymorphisms and breast cancer risk |
| url | http://www.sciencedirect.com/science/article/pii/S2405580825002894 |
| work_keys_str_mv | AT halaosman associationbetweenvegfgenepolymorphismsandbreastcancerrisk AT mozanhassan associationbetweenvegfgenepolymorphismsandbreastcancerrisk AT mohamedalfaki associationbetweenvegfgenepolymorphismsandbreastcancerrisk AT ghadahajali associationbetweenvegfgenepolymorphismsandbreastcancerrisk |