Recent advances in nanomedicine design strategies for targeting subcellular structures
Summary: The current state of cancer treatment has encountered limitations, with each method having its own drawbacks. The emergence of nanotechnology in recent years has highlighted its potential in overcoming these limitations. Nanomedicine offers various drug delivery mechanisms, including passiv...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224028244 |
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| author | Defeng Ye Hua Liu Enci Dai Jiang Fan Liang Wu |
| author_facet | Defeng Ye Hua Liu Enci Dai Jiang Fan Liang Wu |
| author_sort | Defeng Ye |
| collection | DOAJ |
| description | Summary: The current state of cancer treatment has encountered limitations, with each method having its own drawbacks. The emergence of nanotechnology in recent years has highlighted its potential in overcoming these limitations. Nanomedicine offers various drug delivery mechanisms, including passive, active, and endogenous targeting, with the advantage of modifiability and shapability. This flexibility enables researchers to develop tailored treatments for different types of tumors and populations. As nanodrug technology evolves from first to third generation, the focus is now on achieving precise drug delivery by targeting subcellular structures within tumors. This review summarizes the progress made in subcellular structure-targeted nanodrugs over the past 5 years, highlighting design strategies for targeting mitochondria, lysosomes, endoplasmic reticulum, Golgi apparatus, and cytoskeleton. The review also addresses the current status, limitations, and future directions about the research of nanodrugs. |
| format | Article |
| id | doaj-art-c3a01fca27c14f409396c553fed6f90d |
| institution | OA Journals |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-c3a01fca27c14f409396c553fed6f90d2025-08-20T01:57:20ZengElsevieriScience2589-00422025-01-0128111159710.1016/j.isci.2024.111597Recent advances in nanomedicine design strategies for targeting subcellular structuresDefeng Ye0Hua Liu1Enci Dai2Jiang Fan3Liang Wu4Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Gynecology and Obstetrics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Corresponding authorDepartment of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Corresponding authorSummary: The current state of cancer treatment has encountered limitations, with each method having its own drawbacks. The emergence of nanotechnology in recent years has highlighted its potential in overcoming these limitations. Nanomedicine offers various drug delivery mechanisms, including passive, active, and endogenous targeting, with the advantage of modifiability and shapability. This flexibility enables researchers to develop tailored treatments for different types of tumors and populations. As nanodrug technology evolves from first to third generation, the focus is now on achieving precise drug delivery by targeting subcellular structures within tumors. This review summarizes the progress made in subcellular structure-targeted nanodrugs over the past 5 years, highlighting design strategies for targeting mitochondria, lysosomes, endoplasmic reticulum, Golgi apparatus, and cytoskeleton. The review also addresses the current status, limitations, and future directions about the research of nanodrugs.http://www.sciencedirect.com/science/article/pii/S2589004224028244Natural sciencesPhysicsNanoscienceBiological sciencesBiotechnologyNanotechnology |
| spellingShingle | Defeng Ye Hua Liu Enci Dai Jiang Fan Liang Wu Recent advances in nanomedicine design strategies for targeting subcellular structures iScience Natural sciences Physics Nanoscience Biological sciences Biotechnology Nanotechnology |
| title | Recent advances in nanomedicine design strategies for targeting subcellular structures |
| title_full | Recent advances in nanomedicine design strategies for targeting subcellular structures |
| title_fullStr | Recent advances in nanomedicine design strategies for targeting subcellular structures |
| title_full_unstemmed | Recent advances in nanomedicine design strategies for targeting subcellular structures |
| title_short | Recent advances in nanomedicine design strategies for targeting subcellular structures |
| title_sort | recent advances in nanomedicine design strategies for targeting subcellular structures |
| topic | Natural sciences Physics Nanoscience Biological sciences Biotechnology Nanotechnology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224028244 |
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