Mesalazine in Inflammatory Bowel Disease: A Trendy Topic Once Again?
5-aminosalicylic acid (5-ASA) preparations (eg, mesalazine, mesalamine) are well-established preparations used in the management of inflammatory bowel disease. These drugs are most useful for the treatment of mild to moderate flares of ulcerative colitis and, especially, for maintenance of remission...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2010/586092 |
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| author | Marietta Iacucci Shanika de Silva Subrata Ghosh |
| author_facet | Marietta Iacucci Shanika de Silva Subrata Ghosh |
| author_sort | Marietta Iacucci |
| collection | DOAJ |
| description | 5-aminosalicylic acid (5-ASA) preparations (eg, mesalazine, mesalamine) are well-established preparations used in the management of inflammatory bowel disease. These drugs are most useful for the treatment of mild to moderate flares of ulcerative colitis and, especially, for maintenance of remission. Although most gastroenterologists are very familiar with these drugs, the interest in these drugs has undergone a resurgence, with new preparations offering convenience and high dosage, while preserving their customary safety. New dosage regimens are likely to become standard practice in the near future. There is also considerable interest in chemoprevention of colorectal cancer in the context of inflammatory bowel disease, and the role of long-term maintenance therapy with 5-ASAs in achieving such chemoprevention. A mechanism of action for such chemoprevention has been provided by the agonism of the peroxisome proliferator-activated receptor-gamma by 5-ASA, which unifies its efficacy as an anti-inflammatory and chemopreventive agent. In the future, even more effective agents based on 5-ASA are expected, based on more powerful agonism of peroxisome proliferator-activated receptor-gamma; 5-ASA preparations have become ‘trendy’ again. |
| format | Article |
| id | doaj-art-c39d7ed62fd842f8a16e4ca3676e07c8 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-c39d7ed62fd842f8a16e4ca3676e07c82025-02-03T05:59:33ZengWileyCanadian Journal of Gastroenterology0835-79002010-01-0124212713310.1155/2010/586092Mesalazine in Inflammatory Bowel Disease: A Trendy Topic Once Again?Marietta Iacucci0Shanika de Silva1Subrata Ghosh2Gastrointestinal Unit, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United KingdomDivision of Gastroenterology, University of Calgary, Calgary, Alberta, CanadaDivision of Gastroenterology, University of Calgary, Calgary, Alberta, Canada5-aminosalicylic acid (5-ASA) preparations (eg, mesalazine, mesalamine) are well-established preparations used in the management of inflammatory bowel disease. These drugs are most useful for the treatment of mild to moderate flares of ulcerative colitis and, especially, for maintenance of remission. Although most gastroenterologists are very familiar with these drugs, the interest in these drugs has undergone a resurgence, with new preparations offering convenience and high dosage, while preserving their customary safety. New dosage regimens are likely to become standard practice in the near future. There is also considerable interest in chemoprevention of colorectal cancer in the context of inflammatory bowel disease, and the role of long-term maintenance therapy with 5-ASAs in achieving such chemoprevention. A mechanism of action for such chemoprevention has been provided by the agonism of the peroxisome proliferator-activated receptor-gamma by 5-ASA, which unifies its efficacy as an anti-inflammatory and chemopreventive agent. In the future, even more effective agents based on 5-ASA are expected, based on more powerful agonism of peroxisome proliferator-activated receptor-gamma; 5-ASA preparations have become ‘trendy’ again.http://dx.doi.org/10.1155/2010/586092 |
| spellingShingle | Marietta Iacucci Shanika de Silva Subrata Ghosh Mesalazine in Inflammatory Bowel Disease: A Trendy Topic Once Again? Canadian Journal of Gastroenterology |
| title | Mesalazine in Inflammatory Bowel Disease: A Trendy Topic Once Again? |
| title_full | Mesalazine in Inflammatory Bowel Disease: A Trendy Topic Once Again? |
| title_fullStr | Mesalazine in Inflammatory Bowel Disease: A Trendy Topic Once Again? |
| title_full_unstemmed | Mesalazine in Inflammatory Bowel Disease: A Trendy Topic Once Again? |
| title_short | Mesalazine in Inflammatory Bowel Disease: A Trendy Topic Once Again? |
| title_sort | mesalazine in inflammatory bowel disease a trendy topic once again |
| url | http://dx.doi.org/10.1155/2010/586092 |
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