Palm Tocotrienol Supplementation Enhanced Bone Formation in Oestrogen-Deficient Rats
Postmenopausal osteoporosis is the commonest cause of osteoporosis. It is associated with increased free radical activity induced by the oestrogen-deficient state. Therefore, supplementation with palm-oil-derived tocotrienols, a potent antioxidant, should be able to prevent this bone loss. Our earl...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/532862 |
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| author | Ima Nirwana Soelaiman Wang Ming Roshayati Abu Bakar Nursyahrina Atiqah Hashnan Hanif Mohd Ali Norazlina Mohamed Norliza Muhammad Ahmad Nazrun Shuid |
| author_facet | Ima Nirwana Soelaiman Wang Ming Roshayati Abu Bakar Nursyahrina Atiqah Hashnan Hanif Mohd Ali Norazlina Mohamed Norliza Muhammad Ahmad Nazrun Shuid |
| author_sort | Ima Nirwana Soelaiman |
| collection | DOAJ |
| description | Postmenopausal osteoporosis is the commonest cause of osteoporosis. It is associated with increased free radical activity induced by the oestrogen-deficient state. Therefore, supplementation with palm-oil-derived tocotrienols, a potent antioxidant, should be able to prevent this bone loss. Our earlier studies have shown that tocotrienol was able to prevent and even reverse osteoporosis due to various factors, including oestrogen deficiency. In this study we compared the effects of supplementation with palm tocotrienol mixture or calcium on bone biomarkers and bone formation rate in ovariectomised (oestrogen-deficient) female rats. Our results showed that palm tocotrienols significantly increased bone formation in oestrogen-deficient rats, seen by increased double-labeled surface (dLS/Bs), reduced single-labeled surface (sLS/BS), increased mineralizing surface (MS/BS), increased mineral apposition rate (MAR), and an overall increase in bone formation rate (BFR/BS). These effects were not seen in the group supplemented with calcium. However, no significant changes were seen in the serum levels of the bone biomarkers, osteocalcin, and cross-linked C-telopeptide of type I collagen, CTX. In conclusion, palm tocotrienol is more effective than calcium in preventing oestrogen-deficient bone loss. Further studies are needed to determine the potential of tocotrienol as an antiosteoporotic agent. |
| format | Article |
| id | doaj-art-c39ccc83e1bc45169f2df339a41b3e85 |
| institution | DOAJ |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-c39ccc83e1bc45169f2df339a41b3e852025-08-20T03:23:12ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/532862532862Palm Tocotrienol Supplementation Enhanced Bone Formation in Oestrogen-Deficient RatsIma Nirwana Soelaiman0Wang Ming1Roshayati Abu Bakar2Nursyahrina Atiqah Hashnan3Hanif Mohd Ali4Norazlina Mohamed5Norliza Muhammad6Ahmad Nazrun Shuid7Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, MalaysiaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, MalaysiaPostmenopausal osteoporosis is the commonest cause of osteoporosis. It is associated with increased free radical activity induced by the oestrogen-deficient state. Therefore, supplementation with palm-oil-derived tocotrienols, a potent antioxidant, should be able to prevent this bone loss. Our earlier studies have shown that tocotrienol was able to prevent and even reverse osteoporosis due to various factors, including oestrogen deficiency. In this study we compared the effects of supplementation with palm tocotrienol mixture or calcium on bone biomarkers and bone formation rate in ovariectomised (oestrogen-deficient) female rats. Our results showed that palm tocotrienols significantly increased bone formation in oestrogen-deficient rats, seen by increased double-labeled surface (dLS/Bs), reduced single-labeled surface (sLS/BS), increased mineralizing surface (MS/BS), increased mineral apposition rate (MAR), and an overall increase in bone formation rate (BFR/BS). These effects were not seen in the group supplemented with calcium. However, no significant changes were seen in the serum levels of the bone biomarkers, osteocalcin, and cross-linked C-telopeptide of type I collagen, CTX. In conclusion, palm tocotrienol is more effective than calcium in preventing oestrogen-deficient bone loss. Further studies are needed to determine the potential of tocotrienol as an antiosteoporotic agent.http://dx.doi.org/10.1155/2012/532862 |
| spellingShingle | Ima Nirwana Soelaiman Wang Ming Roshayati Abu Bakar Nursyahrina Atiqah Hashnan Hanif Mohd Ali Norazlina Mohamed Norliza Muhammad Ahmad Nazrun Shuid Palm Tocotrienol Supplementation Enhanced Bone Formation in Oestrogen-Deficient Rats International Journal of Endocrinology |
| title | Palm Tocotrienol Supplementation Enhanced Bone Formation in Oestrogen-Deficient Rats |
| title_full | Palm Tocotrienol Supplementation Enhanced Bone Formation in Oestrogen-Deficient Rats |
| title_fullStr | Palm Tocotrienol Supplementation Enhanced Bone Formation in Oestrogen-Deficient Rats |
| title_full_unstemmed | Palm Tocotrienol Supplementation Enhanced Bone Formation in Oestrogen-Deficient Rats |
| title_short | Palm Tocotrienol Supplementation Enhanced Bone Formation in Oestrogen-Deficient Rats |
| title_sort | palm tocotrienol supplementation enhanced bone formation in oestrogen deficient rats |
| url | http://dx.doi.org/10.1155/2012/532862 |
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