Lentiviral CRISPRa/i in the adult prairie vole brain: modulating neuronal gene expression without DNA cleavage

Lentiviral CRISPRa/i in the adult prairie vole brain: modulating neuronal gene expression without DNA cleavage

Prairie voles (Microtus ochrogaster) are a powerful model for studying the neurobiology of social bonding, yet tools for region- and cell type-specific gene regulation remain underdeveloped in this species. Here, we present a lentivirus-mediated CRISPR activation and interference (CRISPRa/i) platfor...

Full description

Saved in:
Bibliographic Details
Main Authors: Meredith K. Loth, Kendall T. Mesch, Celine Herrera-Garcia, Liza E. Brusman, Zoe R. Donaldson
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Genome Editing
Subjects:
CRISPRa
CRISPRi
somatic gene regulation
prairie voles
Oxtr
Avpr1a
Online Access:https://www.frontiersin.org/articles/10.3389/fgeed.2025.1602983/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items