Adhesive polyelectrolyte coating through UV-triggered polymerization on PLGA particles for enhanced drug delivery to inflammatory intestinal mucosa
Abstract Administering medication precisely to the inflamed intestinal sites to treat ulcerative colitis (UC), with minimized side effects, is of urgent need. In UC, the inflammation damaged mucosa contains a large number of amino groups which are positively charged, providing new opportunities for...
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BMC
2025-01-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-024-03066-3 |
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| author | Jie Zhang Yi-jing Yin Xing-wang Wang Wei-qi Lu Zhao-yang Chen Chao-hui Yu Ke-feng Ren Cheng-fu Xu |
| author_facet | Jie Zhang Yi-jing Yin Xing-wang Wang Wei-qi Lu Zhao-yang Chen Chao-hui Yu Ke-feng Ren Cheng-fu Xu |
| author_sort | Jie Zhang |
| collection | DOAJ |
| description | Abstract Administering medication precisely to the inflamed intestinal sites to treat ulcerative colitis (UC), with minimized side effects, is of urgent need. In UC, the inflammation damaged mucosa contains a large number of amino groups which are positively charged, providing new opportunities for drug delivery system design. Here, we report an oral drug delivery system utilizing the tacrolimus-loaded poly (lactic-co-glycolic acid) (TAC/PLGA) particles with an adhesion coating by in situ UV-triggered polymerization of polyacrylic acid and N-hydroxysuccinimide (PAA-NHS). The negatively charged carboxyl groups effectively interact with the positively charged focal mucosa, and the NHS ester groups form the covalent bonds with the amino groups, thereby synergically enhancing the adhesion of the PLGA particles to the focal mucosa. Our findings reveal that, compared to the naked particles, the PAA-NHS coating increases the adhesion of particles to the inflammatory intestine. In a dextran sulfate sodium-induced acute colitis mouse model, the TAC/PLGA particles with PAA-NHS coating exhibits substantial retention of TAC within the inflammatory intestine, enhancing drug delivery efficiency and therapeutic effects. This approach holds promise for UC management, minimizing systemic side effects and optimizing therapeutic outcomes. Graphical abstract |
| format | Article |
| id | doaj-art-c39531c0fc744e1d833d459a21ca5c04 |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-c39531c0fc744e1d833d459a21ca5c042025-01-26T12:50:59ZengBMCJournal of Nanobiotechnology1477-31552025-01-0123111610.1186/s12951-024-03066-3Adhesive polyelectrolyte coating through UV-triggered polymerization on PLGA particles for enhanced drug delivery to inflammatory intestinal mucosaJie Zhang0Yi-jing Yin1Xing-wang Wang2Wei-qi Lu3Zhao-yang Chen4Chao-hui Yu5Ke-feng Ren6Cheng-fu Xu7Department of Gastroenterology, the First Affiliated Hospital, Zhejiang University School of MedicineMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang UniversityMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang UniversityMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang UniversityMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang UniversityDepartment of Gastroenterology, the First Affiliated Hospital, Zhejiang University School of MedicineMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang UniversityDepartment of Gastroenterology, the First Affiliated Hospital, Zhejiang University School of MedicineAbstract Administering medication precisely to the inflamed intestinal sites to treat ulcerative colitis (UC), with minimized side effects, is of urgent need. In UC, the inflammation damaged mucosa contains a large number of amino groups which are positively charged, providing new opportunities for drug delivery system design. Here, we report an oral drug delivery system utilizing the tacrolimus-loaded poly (lactic-co-glycolic acid) (TAC/PLGA) particles with an adhesion coating by in situ UV-triggered polymerization of polyacrylic acid and N-hydroxysuccinimide (PAA-NHS). The negatively charged carboxyl groups effectively interact with the positively charged focal mucosa, and the NHS ester groups form the covalent bonds with the amino groups, thereby synergically enhancing the adhesion of the PLGA particles to the focal mucosa. Our findings reveal that, compared to the naked particles, the PAA-NHS coating increases the adhesion of particles to the inflammatory intestine. In a dextran sulfate sodium-induced acute colitis mouse model, the TAC/PLGA particles with PAA-NHS coating exhibits substantial retention of TAC within the inflammatory intestine, enhancing drug delivery efficiency and therapeutic effects. This approach holds promise for UC management, minimizing systemic side effects and optimizing therapeutic outcomes. Graphical abstracthttps://doi.org/10.1186/s12951-024-03066-3Ulcerative colitisAdhesive coatingUV-triggered polymerizationPLGA particlesDrug delivery |
| spellingShingle | Jie Zhang Yi-jing Yin Xing-wang Wang Wei-qi Lu Zhao-yang Chen Chao-hui Yu Ke-feng Ren Cheng-fu Xu Adhesive polyelectrolyte coating through UV-triggered polymerization on PLGA particles for enhanced drug delivery to inflammatory intestinal mucosa Journal of Nanobiotechnology Ulcerative colitis Adhesive coating UV-triggered polymerization PLGA particles Drug delivery |
| title | Adhesive polyelectrolyte coating through UV-triggered polymerization on PLGA particles for enhanced drug delivery to inflammatory intestinal mucosa |
| title_full | Adhesive polyelectrolyte coating through UV-triggered polymerization on PLGA particles for enhanced drug delivery to inflammatory intestinal mucosa |
| title_fullStr | Adhesive polyelectrolyte coating through UV-triggered polymerization on PLGA particles for enhanced drug delivery to inflammatory intestinal mucosa |
| title_full_unstemmed | Adhesive polyelectrolyte coating through UV-triggered polymerization on PLGA particles for enhanced drug delivery to inflammatory intestinal mucosa |
| title_short | Adhesive polyelectrolyte coating through UV-triggered polymerization on PLGA particles for enhanced drug delivery to inflammatory intestinal mucosa |
| title_sort | adhesive polyelectrolyte coating through uv triggered polymerization on plga particles for enhanced drug delivery to inflammatory intestinal mucosa |
| topic | Ulcerative colitis Adhesive coating UV-triggered polymerization PLGA particles Drug delivery |
| url | https://doi.org/10.1186/s12951-024-03066-3 |
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