Assessment of Inflammasome Activity in Type 2 Diabetes Mellitus and Simple Obesity: Comparative Study
Inflammasome is a multiprotein oligomer complex which is the precursor procaspase-1 and is a component of the innate immune system so that this study aimed to determine the serum levels of interleukin-1? and 18 in patients with T2D and simple obesity in an attempt to clarify the role of inflammasome...
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| Format: | Article |
| Language: | English |
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University of Baghdad, College of Science for Women
2013-12-01
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| Series: | مجلة بغداد للعلوم |
| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2826 |
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| author | Baghdad Science Journal |
| author_facet | Baghdad Science Journal |
| author_sort | Baghdad Science Journal |
| collection | DOAJ |
| description | Inflammasome is a multiprotein oligomer complex which is the precursor procaspase-1 and is a component of the innate immune system so that this study aimed to determine the serum levels of interleukin-1? and 18 in patients with T2D and simple obesity in an attempt to clarify the role of inflammasome in these disorders.Twenty five known cases of T2D, twenty four patients with simple obesity and twenty healthy subjects were randomly recruited from AL-Kindy Teaching Hospital in Baghdad to enroll in this study. All the data about the demographic characteristics and anthropometric measurements were determined in all patients, also the C-reactive protein and serum interleukin (IL)-1? and IL-18 levels were obtained from each patient. The results showed that patients who had positive C-reactive protein (? 6 mg/L) had significant high level of serum 1? and IL-18 levels. Concomitant significant increase in serum levels of IL-1? and IL-18 was observed only in 8% (2 out of 25) of T2D. It concludes that the activity of inflammasome is observed in low percent of T2D and this activity does not related to the obesity. |
| format | Article |
| id | doaj-art-c39415eff3ad485e89938ca1df6793e4 |
| institution | DOAJ |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2013-12-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-c39415eff3ad485e89938ca1df6793e42025-08-20T03:20:30ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862013-12-0110410.21123/bsj.10.4.1144-1149Assessment of Inflammasome Activity in Type 2 Diabetes Mellitus and Simple Obesity: Comparative StudyBaghdad Science JournalInflammasome is a multiprotein oligomer complex which is the precursor procaspase-1 and is a component of the innate immune system so that this study aimed to determine the serum levels of interleukin-1? and 18 in patients with T2D and simple obesity in an attempt to clarify the role of inflammasome in these disorders.Twenty five known cases of T2D, twenty four patients with simple obesity and twenty healthy subjects were randomly recruited from AL-Kindy Teaching Hospital in Baghdad to enroll in this study. All the data about the demographic characteristics and anthropometric measurements were determined in all patients, also the C-reactive protein and serum interleukin (IL)-1? and IL-18 levels were obtained from each patient. The results showed that patients who had positive C-reactive protein (? 6 mg/L) had significant high level of serum 1? and IL-18 levels. Concomitant significant increase in serum levels of IL-1? and IL-18 was observed only in 8% (2 out of 25) of T2D. It concludes that the activity of inflammasome is observed in low percent of T2D and this activity does not related to the obesity.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2826 |
| spellingShingle | Baghdad Science Journal Assessment of Inflammasome Activity in Type 2 Diabetes Mellitus and Simple Obesity: Comparative Study مجلة بغداد للعلوم |
| title | Assessment of Inflammasome Activity in Type 2 Diabetes Mellitus and Simple Obesity: Comparative Study |
| title_full | Assessment of Inflammasome Activity in Type 2 Diabetes Mellitus and Simple Obesity: Comparative Study |
| title_fullStr | Assessment of Inflammasome Activity in Type 2 Diabetes Mellitus and Simple Obesity: Comparative Study |
| title_full_unstemmed | Assessment of Inflammasome Activity in Type 2 Diabetes Mellitus and Simple Obesity: Comparative Study |
| title_short | Assessment of Inflammasome Activity in Type 2 Diabetes Mellitus and Simple Obesity: Comparative Study |
| title_sort | assessment of inflammasome activity in type 2 diabetes mellitus and simple obesity comparative study |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2826 |
| work_keys_str_mv | AT baghdadsciencejournal assessmentofinflammasomeactivityintype2diabetesmellitusandsimpleobesitycomparativestudy |