Design, Molecular Docking, Synthesis, Characterization and Preliminary Evaluation of Novel 1,3,4-Oxadiazole Derivatives as Cyclin-Dependent Kinase 2 Inhibitors

Design, Molecular Docking, Synthesis, Characterization and Preliminary Evaluation of Novel 1,3,4-Oxadiazole Derivatives as Cyclin-Dependent Kinase 2 Inhibitors

Novel 1,3,4-oxadiazole derivatives were designed, synthesized by reaction of semicarbazide hydrochloride with thiophene-2-carbaldehyde to form semicarbazone that undergo iodine-mediated cyclization to form 5-(thiophen-2-yl)-1,3,4-oxadiazol-2-amine which further reacted with different aldehydes to f...

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Bibliographic Details
Main Authors: Yousef Sabah Ali, Monther Faisal Mahdi, Basma Monjid Abd Razik, Talal Aburjai
Format: Article
Language:English
Published: College of Pharmacy / Mustansiriyah University 2025-01-01
Series:Al-Mustansiriyah Journal of Pharmaceutical Sciences
Subjects:
1,3,4-Oxadiazole
Colon Cancer
Molecular Docking
Schiff’s Bases
Online Access:https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1132
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