Cognitive Impairment in Rheumatoid Arthritis: The Role of Pain, Inflammation, and Multimorbidity in Neuropsychological Outcomes
Rheumatoid arthritis (RA) is a chronic autoimmune disease that may affect the central nervous system, leading to cognitive impairment associated with chronic inflammation and pain. <b>Objective</b>: To assess the relationship between cognitive function, disease progression, pain intensit...
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MDPI AG
2025-07-01
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| author | Agnieszka Pigłowska-Juhnke Maia Stanisławska-Kubiak Piotr Kalmus Marzena Waszczak-Jeka Włodzimierz Samborski Ewa Mojs |
| author_facet | Agnieszka Pigłowska-Juhnke Maia Stanisławska-Kubiak Piotr Kalmus Marzena Waszczak-Jeka Włodzimierz Samborski Ewa Mojs |
| author_sort | Agnieszka Pigłowska-Juhnke |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a chronic autoimmune disease that may affect the central nervous system, leading to cognitive impairment associated with chronic inflammation and pain. <b>Objective</b>: To assess the relationship between cognitive function, disease progression, pain intensity, and clinical parameters in patients with RA. <b>Materials and Methods</b>: This study included 62 RA patients, including individuals with comorbid conditions. Cognitive performance was assessed using the Automated Neuropsychological Assessment Metrics (ANAM) battery. Associations between cognitive function and pain intensity (VAS), inflammatory markers (ESR), number of disease flares, and surgical interventions were analyzed. <b>Results</b>: Patients with isolated RA demonstrated better performance in visuospatial memory and cognitive flexibility compared to those with comorbidities. Increased pain intensity and the number of disease flares were associated with impaired attention, memory, and psychomotor speed. <b>Conclusions</b>: Chronic pain and high disease activity in RA negatively impact cognitive functions. Routine neuropsychological assessment should be considered in the comprehensive clinical management of RA patients. |
| format | Article |
| id | doaj-art-c38ea44298714da59450be04b8b041d9 |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj-art-c38ea44298714da59450be04b8b041d92025-08-20T03:04:42ZengMDPI AGBiomedicines2227-90592025-07-01137169910.3390/biomedicines13071699Cognitive Impairment in Rheumatoid Arthritis: The Role of Pain, Inflammation, and Multimorbidity in Neuropsychological OutcomesAgnieszka Pigłowska-Juhnke0Maia Stanisławska-Kubiak1Piotr Kalmus2Marzena Waszczak-Jeka3Włodzimierz Samborski4Ewa Mojs5Department of Clinical Psychology, Poznan University of Medical Sciences, 60-812 Poznań, PolandDepartment of Clinical Psychology, Poznan University of Medical Sciences, 60-812 Poznań, PolandInstitute of Health, WSG University, 85-229 Bydgoszcz, PolandDepartment of Clinical Psychology, Poznan University of Medical Sciences, 60-812 Poznań, PolandDepartment of Rheumatology, Rehabilitation and Internal Medicine, Poznań University of Medical Sciences, 61-545 Poznań, PolandDepartment of Clinical Psychology, Poznan University of Medical Sciences, 60-812 Poznań, PolandRheumatoid arthritis (RA) is a chronic autoimmune disease that may affect the central nervous system, leading to cognitive impairment associated with chronic inflammation and pain. <b>Objective</b>: To assess the relationship between cognitive function, disease progression, pain intensity, and clinical parameters in patients with RA. <b>Materials and Methods</b>: This study included 62 RA patients, including individuals with comorbid conditions. Cognitive performance was assessed using the Automated Neuropsychological Assessment Metrics (ANAM) battery. Associations between cognitive function and pain intensity (VAS), inflammatory markers (ESR), number of disease flares, and surgical interventions were analyzed. <b>Results</b>: Patients with isolated RA demonstrated better performance in visuospatial memory and cognitive flexibility compared to those with comorbidities. Increased pain intensity and the number of disease flares were associated with impaired attention, memory, and psychomotor speed. <b>Conclusions</b>: Chronic pain and high disease activity in RA negatively impact cognitive functions. Routine neuropsychological assessment should be considered in the comprehensive clinical management of RA patients.https://www.mdpi.com/2227-9059/13/7/1699rheumatoid arthritis (RA)chronic painneuropsychological assessmentcognitive impairmentchronic inflammation |
| spellingShingle | Agnieszka Pigłowska-Juhnke Maia Stanisławska-Kubiak Piotr Kalmus Marzena Waszczak-Jeka Włodzimierz Samborski Ewa Mojs Cognitive Impairment in Rheumatoid Arthritis: The Role of Pain, Inflammation, and Multimorbidity in Neuropsychological Outcomes Biomedicines rheumatoid arthritis (RA) chronic pain neuropsychological assessment cognitive impairment chronic inflammation |
| title | Cognitive Impairment in Rheumatoid Arthritis: The Role of Pain, Inflammation, and Multimorbidity in Neuropsychological Outcomes |
| title_full | Cognitive Impairment in Rheumatoid Arthritis: The Role of Pain, Inflammation, and Multimorbidity in Neuropsychological Outcomes |
| title_fullStr | Cognitive Impairment in Rheumatoid Arthritis: The Role of Pain, Inflammation, and Multimorbidity in Neuropsychological Outcomes |
| title_full_unstemmed | Cognitive Impairment in Rheumatoid Arthritis: The Role of Pain, Inflammation, and Multimorbidity in Neuropsychological Outcomes |
| title_short | Cognitive Impairment in Rheumatoid Arthritis: The Role of Pain, Inflammation, and Multimorbidity in Neuropsychological Outcomes |
| title_sort | cognitive impairment in rheumatoid arthritis the role of pain inflammation and multimorbidity in neuropsychological outcomes |
| topic | rheumatoid arthritis (RA) chronic pain neuropsychological assessment cognitive impairment chronic inflammation |
| url | https://www.mdpi.com/2227-9059/13/7/1699 |
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