Sialic Acids in Health and Disease
Vertebrate cell surfaces exhibit intricate arrangements of glycosaminoglycan polymers, which are primarily linked to lipids and proteins. Numerous soluble secreted proteins are also decorated with either individual sugar molecules or their polymers. The carbohydrate polymers commonly possess termina...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Biologics |
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| Online Access: | https://www.mdpi.com/2673-8449/5/2/10 |
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| author | Gerardo N. Guerrero-Flores Fayth M. Butler Veronica L. Martinez Marignac Guangyu Zhang Fabio J. Pacheco Danilo S. Boskovic |
| author_facet | Gerardo N. Guerrero-Flores Fayth M. Butler Veronica L. Martinez Marignac Guangyu Zhang Fabio J. Pacheco Danilo S. Boskovic |
| author_sort | Gerardo N. Guerrero-Flores |
| collection | DOAJ |
| description | Vertebrate cell surfaces exhibit intricate arrangements of glycosaminoglycan polymers, which are primarily linked to lipids and proteins. Numerous soluble secreted proteins are also decorated with either individual sugar molecules or their polymers. The carbohydrate polymers commonly possess terminal nine-carbon sugars, known as sialic acids. Due to their widespread distribution and strategic positioning, sialic acids play a crucial role in mediating and regulating a wide range of physiologic processes and pathologic conditions. Human- or animal-based investigations predominantly concentrate on the effects of sialic acids during infections, inflammations, vascular disorders, or cancers. Further investigations encompass a variety of applications, including cell–cell interactions, signaling, host–pathogen interactions, and other biological functions associated with nutrition, metabolism, or genetic disorders. Nevertheless, future mechanistic investigations are needed to clarify the specific roles of sialic acids in these varied contexts, so that more effective interventions may be developed. |
| format | Article |
| id | doaj-art-c38da02ef2dc4b7197b6495900b716ca |
| institution | Kabale University |
| issn | 2673-8449 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biologics |
| spelling | doaj-art-c38da02ef2dc4b7197b6495900b716ca2025-08-20T03:27:13ZengMDPI AGBiologics2673-84492025-03-01521010.3390/biologics5020010Sialic Acids in Health and DiseaseGerardo N. Guerrero-Flores0Fayth M. Butler1Veronica L. Martinez Marignac2Guangyu Zhang3Fabio J. Pacheco4Danilo S. Boskovic5Interdisciplinary Center for Research in Health and Behavioral Sciences, School of Medicine, Universidad Adventista del Plata, Libertador San Martín 3103, ArgentinaDivision of Biochemistry, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USAInterdisciplinary Laboratory of Biology and Molecular Genetics (IBIOGEM-CONICET), Diamante 3105, ArgentinaDivision of Biochemistry, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USAInterdisciplinary Center for Research in Health and Behavioral Sciences, School of Medicine, Universidad Adventista del Plata, Libertador San Martín 3103, ArgentinaDivision of Biochemistry, Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USAVertebrate cell surfaces exhibit intricate arrangements of glycosaminoglycan polymers, which are primarily linked to lipids and proteins. Numerous soluble secreted proteins are also decorated with either individual sugar molecules or their polymers. The carbohydrate polymers commonly possess terminal nine-carbon sugars, known as sialic acids. Due to their widespread distribution and strategic positioning, sialic acids play a crucial role in mediating and regulating a wide range of physiologic processes and pathologic conditions. Human- or animal-based investigations predominantly concentrate on the effects of sialic acids during infections, inflammations, vascular disorders, or cancers. Further investigations encompass a variety of applications, including cell–cell interactions, signaling, host–pathogen interactions, and other biological functions associated with nutrition, metabolism, or genetic disorders. Nevertheless, future mechanistic investigations are needed to clarify the specific roles of sialic acids in these varied contexts, so that more effective interventions may be developed.https://www.mdpi.com/2673-8449/5/2/10sialic acidsialoglycoconjugatesialidasesialyltransferasesialylationdesialylation |
| spellingShingle | Gerardo N. Guerrero-Flores Fayth M. Butler Veronica L. Martinez Marignac Guangyu Zhang Fabio J. Pacheco Danilo S. Boskovic Sialic Acids in Health and Disease Biologics sialic acid sialoglycoconjugate sialidase sialyltransferase sialylation desialylation |
| title | Sialic Acids in Health and Disease |
| title_full | Sialic Acids in Health and Disease |
| title_fullStr | Sialic Acids in Health and Disease |
| title_full_unstemmed | Sialic Acids in Health and Disease |
| title_short | Sialic Acids in Health and Disease |
| title_sort | sialic acids in health and disease |
| topic | sialic acid sialoglycoconjugate sialidase sialyltransferase sialylation desialylation |
| url | https://www.mdpi.com/2673-8449/5/2/10 |
| work_keys_str_mv | AT gerardonguerreroflores sialicacidsinhealthanddisease AT faythmbutler sialicacidsinhealthanddisease AT veronicalmartinezmarignac sialicacidsinhealthanddisease AT guangyuzhang sialicacidsinhealthanddisease AT fabiojpacheco sialicacidsinhealthanddisease AT danilosboskovic sialicacidsinhealthanddisease |