The association between non-communicable diseases and COVID-19 severity and mortality among infected hospitalized healthcare workers in 29 countries: a cohort study [version 2; peer review: 2 approved, 1 approved with reservations]
Background Due to occupational exposure, healthcare workers (HCWs) have a higher risk of Coronavirus Disease 2019(COVID-19) infection than the general population. Non-communicable diseases (NCDs) may increase the risk of COVID-19-related morbidity and mortality among HCWs, potentially reducing the a...
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F1000 Research Ltd
2025-06-01
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| author | Sartie Kenneh Mustapha Kabba Innocent Nuwagira Sia Morenike Tengbe Jacklyne Ashubwe Pryanka Relan Ibrahim Franklyn Kamara Francis Moses Jonta Kamara Santigie Sesay Ibrahima Kaba Mamud Idriss Kamara Fassou Mathias Grovogui Abdulai Tejan Jalloh Mher Beglaryan Yusuf Sheku Tejan Shermarke Hassan Jerry-Jonas Mbasha |
| author_facet | Sartie Kenneh Mustapha Kabba Innocent Nuwagira Sia Morenike Tengbe Jacklyne Ashubwe Pryanka Relan Ibrahim Franklyn Kamara Francis Moses Jonta Kamara Santigie Sesay Ibrahima Kaba Mamud Idriss Kamara Fassou Mathias Grovogui Abdulai Tejan Jalloh Mher Beglaryan Yusuf Sheku Tejan Shermarke Hassan Jerry-Jonas Mbasha |
| author_sort | Sartie Kenneh |
| collection | DOAJ |
| description | Background Due to occupational exposure, healthcare workers (HCWs) have a higher risk of Coronavirus Disease 2019(COVID-19) infection than the general population. Non-communicable diseases (NCDs) may increase the risk of COVID-19-related morbidity and mortality among HCWs, potentially reducing the available health workforce. We examined the association between NCDs and COVID-19 disease severity and mortality among infected HCWs. Methods This cohort study used data from the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) database. HCWs hospitalized between January 2020 and January 2023 due to clinically suspected or laboratory-confirmed COVID-19 were eligible for inclusion. Variables collected included demographic data, comorbidities, and hospitalization outcomes. Descriptive statistics were reported using mean/standard deviation (SD), median/interquartile range (IQR), or frequencies and proportions. For each NCD, the relative risk of death, adjusted for age and sex, was calculated using log-binomial regression as well as the population-attributable fraction. Results There were 17,502 HCWs, 95.7% of whom had a confirmed COVID-19 diagnosis. The majority were female (66.5%) and the mean age (SD) was 49.8 (14.3) years. Roughly, half (51.42%) of HCWs had no comorbidities, 29.28% had one comorbidity, 14.68% had 2 comorbidities and <5% had ≥3 comorbidities. The most common comorbidities were diabetes mellitus (49.40%) and cardiovascular disease (36.90%). Approximately one-fifth of the HCWs had severe COVID-19 (16.95%) and 10.68% of the HCWs with COVID-19 died. Being ≥45 years old, male gender, smoking, obesity, and certain NCDs increased the risk of COVID-19 severity and mortality. Obesity and diabetes mellitus were the leading risk factors in terms of the population-attributable risk for COVID-19 severity (6.89%) and mortality (36.00%) respectively. Conclusions Many HCWs with COVID-19 had one or more NCDs. Obesity and diabetes mellitus increased COVID-19 severity and mortality risk. Reducing the prevalence of obesity and diabetes mellitus would yield the biggest reduction in COVID-19-related morbidity and mortality among HCWs. |
| format | Article |
| id | doaj-art-c38d5ed2f18a4dc986311a303ed36bed |
| institution | Kabale University |
| issn | 2046-1402 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | F1000 Research Ltd |
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| spelling | doaj-art-c38d5ed2f18a4dc986311a303ed36bed2025-08-20T03:24:59ZengF1000 Research LtdF1000Research2046-14022025-06-011310.12688/f1000research.150838.2183478The association between non-communicable diseases and COVID-19 severity and mortality among infected hospitalized healthcare workers in 29 countries: a cohort study [version 2; peer review: 2 approved, 1 approved with reservations]Sartie Kenneh0Mustapha Kabba1Innocent Nuwagira2Sia Morenike Tengbe3https://orcid.org/0000-0001-7287-4426Jacklyne Ashubwe4https://orcid.org/0000-0002-1451-2723Pryanka Relan5https://orcid.org/0000-0002-9543-7891Ibrahim Franklyn Kamara6https://orcid.org/0000-0003-1454-4650Francis Moses7https://orcid.org/0000-0002-9490-6537Jonta Kamara8https://orcid.org/0000-0002-2143-3900Santigie Sesay9Ibrahima Kaba10Mamud Idriss Kamara11Fassou Mathias Grovogui12Abdulai Tejan Jalloh13Mher Beglaryan14Yusuf Sheku Tejan15https://orcid.org/0000-0001-6113-7420Shermarke Hassan16Jerry-Jonas Mbasha17Ministry of Health, 4th Floor, Youyi Building, Freetown, Sierra LeoneMinistry of Health, 4th Floor, Youyi Building, Freetown, Sierra LeoneWorld Health Organization Country Office, 21 A-B Kingharman Road, Freetown, Sierra LeoneMinistry of Health, 4th Floor, Youyi Building, Freetown, Sierra LeoneMedwise Solutions Consultancy, Nairobi, P.O. Box 2356 00202, KenyaWorld Health Organization, Headquarters, Geneva, SwitzerlandWorld Health Organization Country Office, 21 A-B Kingharman Road, Freetown, Sierra LeoneMinistry of Health, 4th Floor, Youyi Building, Freetown, Sierra LeoneMultidisciplinary Adolescent and Youth Review Board, Second Lancet Commission on Adolescent Health and Wellbeing, Toronto, Ontario, CanadaMinistry of Health, 4th Floor, Youyi Building, Freetown, Sierra LeoneAfrica Center of Excellence for the Prevention and Control of Communicable Diseases, University Gamal Abdel Nasser, Conakry, GuineaMinistry of Health, 4th Floor, Youyi Building, Freetown, Sierra LeoneAfrica Center of Excellence for the Prevention and Control of Communicable Diseases, University Gamal Abdel Nasser, Conakry, GuineaMinistry of Health, 4th Floor, Youyi Building, Freetown, Sierra LeoneTuberculosis Research and Prevention Centre, Yerevan, 0014, ArmeniaMinistry of Health, 4th Floor, Youyi Building, Freetown, Sierra LeoneInfectious Diseases Data Observatory, University of Oxford, Oxford, UKWorld Health Organization, Africa Regional Office, Brazzaville, CongoBackground Due to occupational exposure, healthcare workers (HCWs) have a higher risk of Coronavirus Disease 2019(COVID-19) infection than the general population. Non-communicable diseases (NCDs) may increase the risk of COVID-19-related morbidity and mortality among HCWs, potentially reducing the available health workforce. We examined the association between NCDs and COVID-19 disease severity and mortality among infected HCWs. Methods This cohort study used data from the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) database. HCWs hospitalized between January 2020 and January 2023 due to clinically suspected or laboratory-confirmed COVID-19 were eligible for inclusion. Variables collected included demographic data, comorbidities, and hospitalization outcomes. Descriptive statistics were reported using mean/standard deviation (SD), median/interquartile range (IQR), or frequencies and proportions. For each NCD, the relative risk of death, adjusted for age and sex, was calculated using log-binomial regression as well as the population-attributable fraction. Results There were 17,502 HCWs, 95.7% of whom had a confirmed COVID-19 diagnosis. The majority were female (66.5%) and the mean age (SD) was 49.8 (14.3) years. Roughly, half (51.42%) of HCWs had no comorbidities, 29.28% had one comorbidity, 14.68% had 2 comorbidities and <5% had ≥3 comorbidities. The most common comorbidities were diabetes mellitus (49.40%) and cardiovascular disease (36.90%). Approximately one-fifth of the HCWs had severe COVID-19 (16.95%) and 10.68% of the HCWs with COVID-19 died. Being ≥45 years old, male gender, smoking, obesity, and certain NCDs increased the risk of COVID-19 severity and mortality. Obesity and diabetes mellitus were the leading risk factors in terms of the population-attributable risk for COVID-19 severity (6.89%) and mortality (36.00%) respectively. Conclusions Many HCWs with COVID-19 had one or more NCDs. Obesity and diabetes mellitus increased COVID-19 severity and mortality risk. Reducing the prevalence of obesity and diabetes mellitus would yield the biggest reduction in COVID-19-related morbidity and mortality among HCWs.https://f1000research.com/articles/13-624/v2COVID-19 Healthcare workers Noncommunicable diseases Mortality Disease severity SORT ITeng |
| spellingShingle | Sartie Kenneh Mustapha Kabba Innocent Nuwagira Sia Morenike Tengbe Jacklyne Ashubwe Pryanka Relan Ibrahim Franklyn Kamara Francis Moses Jonta Kamara Santigie Sesay Ibrahima Kaba Mamud Idriss Kamara Fassou Mathias Grovogui Abdulai Tejan Jalloh Mher Beglaryan Yusuf Sheku Tejan Shermarke Hassan Jerry-Jonas Mbasha The association between non-communicable diseases and COVID-19 severity and mortality among infected hospitalized healthcare workers in 29 countries: a cohort study [version 2; peer review: 2 approved, 1 approved with reservations] F1000Research COVID-19 Healthcare workers Noncommunicable diseases Mortality Disease severity SORT IT eng |
| title | The association between non-communicable diseases and COVID-19 severity and mortality among infected hospitalized healthcare workers in 29 countries: a cohort study [version 2; peer review: 2 approved, 1 approved with reservations] |
| title_full | The association between non-communicable diseases and COVID-19 severity and mortality among infected hospitalized healthcare workers in 29 countries: a cohort study [version 2; peer review: 2 approved, 1 approved with reservations] |
| title_fullStr | The association between non-communicable diseases and COVID-19 severity and mortality among infected hospitalized healthcare workers in 29 countries: a cohort study [version 2; peer review: 2 approved, 1 approved with reservations] |
| title_full_unstemmed | The association between non-communicable diseases and COVID-19 severity and mortality among infected hospitalized healthcare workers in 29 countries: a cohort study [version 2; peer review: 2 approved, 1 approved with reservations] |
| title_short | The association between non-communicable diseases and COVID-19 severity and mortality among infected hospitalized healthcare workers in 29 countries: a cohort study [version 2; peer review: 2 approved, 1 approved with reservations] |
| title_sort | association between non communicable diseases and covid 19 severity and mortality among infected hospitalized healthcare workers in 29 countries a cohort study version 2 peer review 2 approved 1 approved with reservations |
| topic | COVID-19 Healthcare workers Noncommunicable diseases Mortality Disease severity SORT IT eng |
| url | https://f1000research.com/articles/13-624/v2 |
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