Lycii Radicis Cortex suppresses the growth of non-small cell lung cancer via enhancing the anti-tumor immunity
Lycii Radicis Cortex (LRC) is a medicinal and food homologous plant with various pharmacological activities, including anti-tumor effects. This study explores the anti-tumor effect of LRC on non-small cell lung cancer (NSCLC) and its molecular mechanism using mice bearing Lewis lung carcinoma cells....
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2025-02-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2024.9250041 |
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| author | Heng Yin Meng Liu Yaling Zhao Haitao Wu Danna Zheng Zhenhui Guo Ying Zhou Shaofeng Wu Chuanbing Chen Lei Zhang Shanshan Song Yanli He Ren Zhang |
| author_facet | Heng Yin Meng Liu Yaling Zhao Haitao Wu Danna Zheng Zhenhui Guo Ying Zhou Shaofeng Wu Chuanbing Chen Lei Zhang Shanshan Song Yanli He Ren Zhang |
| author_sort | Heng Yin |
| collection | DOAJ |
| description | Lycii Radicis Cortex (LRC) is a medicinal and food homologous plant with various pharmacological activities, including anti-tumor effects. This study explores the anti-tumor effect of LRC on non-small cell lung cancer (NSCLC) and its molecular mechanism using mice bearing Lewis lung carcinoma cells. LRC significantly suppressed the growth of NSCLC. Besides, RNA sequencing of mice tumors and hematoxylin & eosin and immunofluorescence staining revealed that LRC promoted the infiltration of T lymphocytes, specifically GZMB+CD8+T lymphocytes, in tumor tissues. The Gene Set Enrichment Analysis of spleen RNA indicated that LRC up-regulated PD-1-downstream pathways, suggesting that LRC exerted its effects through the PD-L1/PD-1 pathway. Further experiments revealed that LRC interacted with PD-L1, blocking PD-L1/PD-1 binding and thus restoring the T cell killing activity on tumor cells. Together, these results support using LRC as healthy food to improve anti-tumor immunity in patients with NSCLC. |
| format | Article |
| id | doaj-art-c38c475890e34ae4b794fe8654d6eedc |
| institution | OA Journals |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-c38c475890e34ae4b794fe8654d6eedc2025-08-20T02:05:19ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302025-02-01142925004110.26599/FSHW.2024.9250041Lycii Radicis Cortex suppresses the growth of non-small cell lung cancer via enhancing the anti-tumor immunityHeng Yin0Meng Liu1Yaling Zhao2Haitao Wu3Danna Zheng4Zhenhui Guo5Ying Zhou6Shaofeng Wu7Chuanbing Chen8Lei Zhang9Shanshan Song10Yanli He11Ren Zhang12Research Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaResearch Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaResearch Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaThe First Affiliated Hospital of Jinan University, Guangzhou 510006, ChinaResearch Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaResearch Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaResearch Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaSchool of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaIntegrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510315, ChinaDepartment of Pathology and Pathophysiology, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaResearch Centre of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, ChinaLycii Radicis Cortex (LRC) is a medicinal and food homologous plant with various pharmacological activities, including anti-tumor effects. This study explores the anti-tumor effect of LRC on non-small cell lung cancer (NSCLC) and its molecular mechanism using mice bearing Lewis lung carcinoma cells. LRC significantly suppressed the growth of NSCLC. Besides, RNA sequencing of mice tumors and hematoxylin & eosin and immunofluorescence staining revealed that LRC promoted the infiltration of T lymphocytes, specifically GZMB+CD8+T lymphocytes, in tumor tissues. The Gene Set Enrichment Analysis of spleen RNA indicated that LRC up-regulated PD-1-downstream pathways, suggesting that LRC exerted its effects through the PD-L1/PD-1 pathway. Further experiments revealed that LRC interacted with PD-L1, blocking PD-L1/PD-1 binding and thus restoring the T cell killing activity on tumor cells. Together, these results support using LRC as healthy food to improve anti-tumor immunity in patients with NSCLC.https://www.sciopen.com/article/10.26599/FSHW.2024.9250041lycii radicis cortexnon-small cell lung cancerpd-l1immune checkpoint |
| spellingShingle | Heng Yin Meng Liu Yaling Zhao Haitao Wu Danna Zheng Zhenhui Guo Ying Zhou Shaofeng Wu Chuanbing Chen Lei Zhang Shanshan Song Yanli He Ren Zhang Lycii Radicis Cortex suppresses the growth of non-small cell lung cancer via enhancing the anti-tumor immunity Food Science and Human Wellness lycii radicis cortex non-small cell lung cancer pd-l1 immune checkpoint |
| title | Lycii Radicis Cortex suppresses the growth of non-small cell lung cancer via enhancing the anti-tumor immunity |
| title_full | Lycii Radicis Cortex suppresses the growth of non-small cell lung cancer via enhancing the anti-tumor immunity |
| title_fullStr | Lycii Radicis Cortex suppresses the growth of non-small cell lung cancer via enhancing the anti-tumor immunity |
| title_full_unstemmed | Lycii Radicis Cortex suppresses the growth of non-small cell lung cancer via enhancing the anti-tumor immunity |
| title_short | Lycii Radicis Cortex suppresses the growth of non-small cell lung cancer via enhancing the anti-tumor immunity |
| title_sort | lycii radicis cortex suppresses the growth of non small cell lung cancer via enhancing the anti tumor immunity |
| topic | lycii radicis cortex non-small cell lung cancer pd-l1 immune checkpoint |
| url | https://www.sciopen.com/article/10.26599/FSHW.2024.9250041 |
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