Plasmalogens in Innate Immune Cells: From Arachidonate Signaling to Ferroptosis
Polyunsaturated fatty acids such as arachidonic acid are indispensable components of innate immune signaling. Plasmalogens are glycerophospholipids with a vinyl ether bond in the sn-1 position of the glycerol backbone instead of the more common sn-1 ester bond present in “classical” glycerophospholi...
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MDPI AG
2024-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/11/1461 |
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| author | Jesús Balsinde María A. Balboa |
| author_facet | Jesús Balsinde María A. Balboa |
| author_sort | Jesús Balsinde |
| collection | DOAJ |
| description | Polyunsaturated fatty acids such as arachidonic acid are indispensable components of innate immune signaling. Plasmalogens are glycerophospholipids with a vinyl ether bond in the sn-1 position of the glycerol backbone instead of the more common sn-1 ester bond present in “classical” glycerophospholipids. This kind of phospholipid is particularly rich in polyunsaturated fatty acids, especially arachidonic acid. In addition to or independently of the role of plasmalogens as major providers of free arachidonic acid for eicosanoid synthesis, plasmalogens also perform a varied number of functions. Membrane plasmalogen levels may determine parameters of the plasma membrane, such as fluidity and the formation of microdomains that are necessary for efficient signal transduction leading to optimal phagocytosis by macrophages. Also, plasmalogens may be instrumental for the execution of ferroptosis. This is a nonapoptotic form of cell death that is associated with oxidative stress. This review discusses recent data suggesting that, beyond their involvement in the cellular metabolism of arachidonic acid, the cells maintain stable pools of plasmalogens rich in polyunsaturated fatty acids for executing specific responses. |
| format | Article |
| id | doaj-art-c38b143faa58447eab561b2b0762ab34 |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-c38b143faa58447eab561b2b0762ab342025-08-20T02:28:11ZengMDPI AGBiomolecules2218-273X2024-11-011411146110.3390/biom14111461Plasmalogens in Innate Immune Cells: From Arachidonate Signaling to FerroptosisJesús Balsinde0María A. Balboa1Instituto de Biología y Geneética Molecular, Consejo Superior de Investigaciones Científicas Uva, 47003 Valladolid, SpainInstituto de Biología y Geneética Molecular, Consejo Superior de Investigaciones Científicas Uva, 47003 Valladolid, SpainPolyunsaturated fatty acids such as arachidonic acid are indispensable components of innate immune signaling. Plasmalogens are glycerophospholipids with a vinyl ether bond in the sn-1 position of the glycerol backbone instead of the more common sn-1 ester bond present in “classical” glycerophospholipids. This kind of phospholipid is particularly rich in polyunsaturated fatty acids, especially arachidonic acid. In addition to or independently of the role of plasmalogens as major providers of free arachidonic acid for eicosanoid synthesis, plasmalogens also perform a varied number of functions. Membrane plasmalogen levels may determine parameters of the plasma membrane, such as fluidity and the formation of microdomains that are necessary for efficient signal transduction leading to optimal phagocytosis by macrophages. Also, plasmalogens may be instrumental for the execution of ferroptosis. This is a nonapoptotic form of cell death that is associated with oxidative stress. This review discusses recent data suggesting that, beyond their involvement in the cellular metabolism of arachidonic acid, the cells maintain stable pools of plasmalogens rich in polyunsaturated fatty acids for executing specific responses.https://www.mdpi.com/2218-273X/14/11/1461plasmalogensarachidonic acidpolyunsaturated fatty acidsinflammationinnate immunityferroptosis |
| spellingShingle | Jesús Balsinde María A. Balboa Plasmalogens in Innate Immune Cells: From Arachidonate Signaling to Ferroptosis Biomolecules plasmalogens arachidonic acid polyunsaturated fatty acids inflammation innate immunity ferroptosis |
| title | Plasmalogens in Innate Immune Cells: From Arachidonate Signaling to Ferroptosis |
| title_full | Plasmalogens in Innate Immune Cells: From Arachidonate Signaling to Ferroptosis |
| title_fullStr | Plasmalogens in Innate Immune Cells: From Arachidonate Signaling to Ferroptosis |
| title_full_unstemmed | Plasmalogens in Innate Immune Cells: From Arachidonate Signaling to Ferroptosis |
| title_short | Plasmalogens in Innate Immune Cells: From Arachidonate Signaling to Ferroptosis |
| title_sort | plasmalogens in innate immune cells from arachidonate signaling to ferroptosis |
| topic | plasmalogens arachidonic acid polyunsaturated fatty acids inflammation innate immunity ferroptosis |
| url | https://www.mdpi.com/2218-273X/14/11/1461 |
| work_keys_str_mv | AT jesusbalsinde plasmalogensininnateimmunecellsfromarachidonatesignalingtoferroptosis AT mariaabalboa plasmalogensininnateimmunecellsfromarachidonatesignalingtoferroptosis |