Association between Atherogenic index of plasma and gallstones in the United States adults: A cross-sectional analysis of NHANES 2017–2020
Background: Although substantial evidence suggests an association between dyslipidemia as an isolated factor and gallstones, research on the Atherogenic Index of Plasma (AIP) and gallstones remains limited. Methods: A total of 3557 eligible adults from the United States were selected for cross-secti...
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Elsevier
2025-02-01
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| Series: | Preventive Medicine Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211335525000117 |
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| author | Shuang Yang Jianhui Song Zhengbo Yang Nanbo Li Ju Wu Shuangshuang Hou |
| author_facet | Shuang Yang Jianhui Song Zhengbo Yang Nanbo Li Ju Wu Shuangshuang Hou |
| author_sort | Shuang Yang |
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| description | Background: Although substantial evidence suggests an association between dyslipidemia as an isolated factor and gallstones, research on the Atherogenic Index of Plasma (AIP) and gallstones remains limited. Methods: A total of 3557 eligible adults from the United States were selected for cross-sectional analysis using the 2017–2020 National Health and Nutrition Examination Survey database. Logistic regression was employed to evaluate the association between AIP gallstones. Restricted cubic spline (RCS) analysis and threshold effect analysis were conducted to explore potential non-linear relationship. Results: The study found a positive association between higher AIP levels and higher odds of gallstones. In the fully adjusted logistic regression model, each 1-unit increase in AIP was associated with 59 % higher odds of gallstones (OR = 1.59, 95 % CI: 1.06, 2.38). Compared to the lowest quartile of AIP, the highest quartile showed 82 % higher odds of gallstones (OR = 1.82, 95 % CI: 1.23, 2.69). RCS analysis revealed a non-linear relationship between AIP and gallstones, with threshold effect analysis identifying a turning point at −0.13, where AIP had a positive correlation with gallstones before this threshold. Conclusion: Higher AIP is positively correlated with higher odds of gallstones, showing a non-linear relationship. As AIP increases, the odds of gallstones also rise, but this relationship is no longer observed beyond a certain threshold. It is recommended to maintain appropriate AIP levels to reduce the incidence of gallstones. |
| format | Article |
| id | doaj-art-c380b2a65b2242129d0ae1ff2c227984 |
| institution | Kabale University |
| issn | 2211-3355 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
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| series | Preventive Medicine Reports |
| spelling | doaj-art-c380b2a65b2242129d0ae1ff2c2279842025-02-08T05:00:15ZengElsevierPreventive Medicine Reports2211-33552025-02-0150102972Association between Atherogenic index of plasma and gallstones in the United States adults: A cross-sectional analysis of NHANES 2017–2020Shuang Yang0Jianhui Song1Zhengbo Yang2Nanbo Li3Ju Wu4Shuangshuang Hou5Department of Operating room, Fuyang Normal University Second Affiliated Hospital, Fuyang 236000, Anhui, ChinaDepartment of General Surgery, Affiliated Xinhua Hospital of Dalian University, Dalian 116001, Liaoning, ChinaDepartment of General Surgery, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning, ChinaDepartment of General Surgery, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning, ChinaDepartment of General Surgery, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning, ChinaDepartment of Graduate School, Dalian Medical University, Dalian 116000, Liaoning, China; Corresponding author.Background: Although substantial evidence suggests an association between dyslipidemia as an isolated factor and gallstones, research on the Atherogenic Index of Plasma (AIP) and gallstones remains limited. Methods: A total of 3557 eligible adults from the United States were selected for cross-sectional analysis using the 2017–2020 National Health and Nutrition Examination Survey database. Logistic regression was employed to evaluate the association between AIP gallstones. Restricted cubic spline (RCS) analysis and threshold effect analysis were conducted to explore potential non-linear relationship. Results: The study found a positive association between higher AIP levels and higher odds of gallstones. In the fully adjusted logistic regression model, each 1-unit increase in AIP was associated with 59 % higher odds of gallstones (OR = 1.59, 95 % CI: 1.06, 2.38). Compared to the lowest quartile of AIP, the highest quartile showed 82 % higher odds of gallstones (OR = 1.82, 95 % CI: 1.23, 2.69). RCS analysis revealed a non-linear relationship between AIP and gallstones, with threshold effect analysis identifying a turning point at −0.13, where AIP had a positive correlation with gallstones before this threshold. Conclusion: Higher AIP is positively correlated with higher odds of gallstones, showing a non-linear relationship. As AIP increases, the odds of gallstones also rise, but this relationship is no longer observed beyond a certain threshold. It is recommended to maintain appropriate AIP levels to reduce the incidence of gallstones.http://www.sciencedirect.com/science/article/pii/S2211335525000117Atherogenic index of plasmaGallstonesNon-linear relationshipNHANESCross-sectional study |
| spellingShingle | Shuang Yang Jianhui Song Zhengbo Yang Nanbo Li Ju Wu Shuangshuang Hou Association between Atherogenic index of plasma and gallstones in the United States adults: A cross-sectional analysis of NHANES 2017–2020 Preventive Medicine Reports Atherogenic index of plasma Gallstones Non-linear relationship NHANES Cross-sectional study |
| title | Association between Atherogenic index of plasma and gallstones in the United States adults: A cross-sectional analysis of NHANES 2017–2020 |
| title_full | Association between Atherogenic index of plasma and gallstones in the United States adults: A cross-sectional analysis of NHANES 2017–2020 |
| title_fullStr | Association between Atherogenic index of plasma and gallstones in the United States adults: A cross-sectional analysis of NHANES 2017–2020 |
| title_full_unstemmed | Association between Atherogenic index of plasma and gallstones in the United States adults: A cross-sectional analysis of NHANES 2017–2020 |
| title_short | Association between Atherogenic index of plasma and gallstones in the United States adults: A cross-sectional analysis of NHANES 2017–2020 |
| title_sort | association between atherogenic index of plasma and gallstones in the united states adults a cross sectional analysis of nhanes 2017 2020 |
| topic | Atherogenic index of plasma Gallstones Non-linear relationship NHANES Cross-sectional study |
| url | http://www.sciencedirect.com/science/article/pii/S2211335525000117 |
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