Quality Assessment of Native Iranian Cedar and Citrus Honeys: Bioactive Components, Antioxidant Activity, and Estrogenic Properties in MCF-7 Cells
This study investigates the antioxidant and estrogenic properties of native Iranian honeys, particularly in human breast cancer. Honey’s bioactive compounds are crucial in combating oxidative stress and preventing chronic diseases such as cancer, yet limited research has focused on these effects spe...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Journal of Food Quality |
| Online Access: | http://dx.doi.org/10.1155/jfq/4928391 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849310306978758656 |
|---|---|
| author | Maryam Asnaashari Zahra Tayarani-Najaran Dina Shahrampour Ataollah Rahimi |
| author_facet | Maryam Asnaashari Zahra Tayarani-Najaran Dina Shahrampour Ataollah Rahimi |
| author_sort | Maryam Asnaashari |
| collection | DOAJ |
| description | This study investigates the antioxidant and estrogenic properties of native Iranian honeys, particularly in human breast cancer. Honey’s bioactive compounds are crucial in combating oxidative stress and preventing chronic diseases such as cancer, yet limited research has focused on these effects specific to Iranian honeys. Utilizing the E-screen method, the proliferative effects (PEs) of cedar and citrus honeys versus commercial varieties were analyzed. The findings revealed that cedar honey possessed the highest phenolic content (93.09 mg/100 g) followed by citrus honey of southern Iran (61.06 mg/100 g) and citrus honey of northern Iran (43.18 mg/100 g), significantly enhancing its antioxidant activity, as evidenced by a DPPH free radical inhibition of 47.1%. Estrogenic activity was also notable, with cedar honey promoting MCF-7 cell proliferation (PE = 1.21) more effectively than other samples. However, increased concentrations induced cytotoxic effects, inhibiting cell growth from 5 mg/mL onwards. Intriguingly, citrus honeys also elevated intracellular reactive oxygen species (ROS) at 0.1 mg/mL, suggesting a complex interplay between antioxidant and estrogenic actions. Also, cedar honey had a greater ability to inhibit MCF-7 cells with an apoptosis rate of 25.5% compared to the others. Overall, cedar and citrus honeys exhibit dose-dependent estrogenic activity and promote ROS production, underscoring their potential as functional foods in cancer prevention strategies. |
| format | Article |
| id | doaj-art-c37ba4d403754fe7bdc69fc42b678ea1 |
| institution | Kabale University |
| issn | 1745-4557 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Food Quality |
| spelling | doaj-art-c37ba4d403754fe7bdc69fc42b678ea12025-08-20T03:53:46ZengWileyJournal of Food Quality1745-45572025-01-01202510.1155/jfq/4928391Quality Assessment of Native Iranian Cedar and Citrus Honeys: Bioactive Components, Antioxidant Activity, and Estrogenic Properties in MCF-7 CellsMaryam Asnaashari0Zahra Tayarani-Najaran1Dina Shahrampour2Ataollah Rahimi3Halal Research Center of IRITargeted Drug Delivery Research CenterDepartment of Food Safety and Quality ControlAnimal Science Research DepartmentThis study investigates the antioxidant and estrogenic properties of native Iranian honeys, particularly in human breast cancer. Honey’s bioactive compounds are crucial in combating oxidative stress and preventing chronic diseases such as cancer, yet limited research has focused on these effects specific to Iranian honeys. Utilizing the E-screen method, the proliferative effects (PEs) of cedar and citrus honeys versus commercial varieties were analyzed. The findings revealed that cedar honey possessed the highest phenolic content (93.09 mg/100 g) followed by citrus honey of southern Iran (61.06 mg/100 g) and citrus honey of northern Iran (43.18 mg/100 g), significantly enhancing its antioxidant activity, as evidenced by a DPPH free radical inhibition of 47.1%. Estrogenic activity was also notable, with cedar honey promoting MCF-7 cell proliferation (PE = 1.21) more effectively than other samples. However, increased concentrations induced cytotoxic effects, inhibiting cell growth from 5 mg/mL onwards. Intriguingly, citrus honeys also elevated intracellular reactive oxygen species (ROS) at 0.1 mg/mL, suggesting a complex interplay between antioxidant and estrogenic actions. Also, cedar honey had a greater ability to inhibit MCF-7 cells with an apoptosis rate of 25.5% compared to the others. Overall, cedar and citrus honeys exhibit dose-dependent estrogenic activity and promote ROS production, underscoring their potential as functional foods in cancer prevention strategies.http://dx.doi.org/10.1155/jfq/4928391 |
| spellingShingle | Maryam Asnaashari Zahra Tayarani-Najaran Dina Shahrampour Ataollah Rahimi Quality Assessment of Native Iranian Cedar and Citrus Honeys: Bioactive Components, Antioxidant Activity, and Estrogenic Properties in MCF-7 Cells Journal of Food Quality |
| title | Quality Assessment of Native Iranian Cedar and Citrus Honeys: Bioactive Components, Antioxidant Activity, and Estrogenic Properties in MCF-7 Cells |
| title_full | Quality Assessment of Native Iranian Cedar and Citrus Honeys: Bioactive Components, Antioxidant Activity, and Estrogenic Properties in MCF-7 Cells |
| title_fullStr | Quality Assessment of Native Iranian Cedar and Citrus Honeys: Bioactive Components, Antioxidant Activity, and Estrogenic Properties in MCF-7 Cells |
| title_full_unstemmed | Quality Assessment of Native Iranian Cedar and Citrus Honeys: Bioactive Components, Antioxidant Activity, and Estrogenic Properties in MCF-7 Cells |
| title_short | Quality Assessment of Native Iranian Cedar and Citrus Honeys: Bioactive Components, Antioxidant Activity, and Estrogenic Properties in MCF-7 Cells |
| title_sort | quality assessment of native iranian cedar and citrus honeys bioactive components antioxidant activity and estrogenic properties in mcf 7 cells |
| url | http://dx.doi.org/10.1155/jfq/4928391 |
| work_keys_str_mv | AT maryamasnaashari qualityassessmentofnativeiraniancedarandcitrushoneysbioactivecomponentsantioxidantactivityandestrogenicpropertiesinmcf7cells AT zahratayaraninajaran qualityassessmentofnativeiraniancedarandcitrushoneysbioactivecomponentsantioxidantactivityandestrogenicpropertiesinmcf7cells AT dinashahrampour qualityassessmentofnativeiraniancedarandcitrushoneysbioactivecomponentsantioxidantactivityandestrogenicpropertiesinmcf7cells AT ataollahrahimi qualityassessmentofnativeiraniancedarandcitrushoneysbioactivecomponentsantioxidantactivityandestrogenicpropertiesinmcf7cells |