Five-Month Observation of Persistent Diabetic Macular Edema after Intravitreal Injection of Ozurdex Implant
Aims. This retrospective analysis was aimed at evaluating the effectiveness of treatment of persistent diabetic macular edema with intravitreal injections of 0.7 mg dexamethasone implant Ozurdex. The study comprised three male patien...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/364143 |
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| author | Dominik Zalewski Dorota Raczyńska Krystyna Raczyńska |
| author_facet | Dominik Zalewski Dorota Raczyńska Krystyna Raczyńska |
| author_sort | Dominik Zalewski |
| collection | DOAJ |
| description | Aims. This retrospective analysis was aimed at evaluating the
effectiveness of treatment of persistent diabetic macular edema with
intravitreal injections of 0.7 mg dexamethasone implant Ozurdex.
The study comprised three male patients (6 eyes). Results. The
average thickness of the retina at baseline was 632 μm, the medial
BCVA was 0.8 logMAR, and corrected intraocular pressure was 13.7 mmHg.
The maximum decrease in mean retinal thickness was observed at four weeks following the
treatment and was 365 μm (−267 μm) and visual acuity
improved by an average of two lines and was 0.6 logMAR. The largest increase in mean retinal
thickness to average of 528 μm (+164 μm) occurred at 16
weeks and the average BCVA was 0.614 lines BCVA logMAR. In one eye, there was a steroid
cataract development after the third dose of dexamethasone implant of 0.7 mg. Conclusions.
The intravitreal dexamethasone implant treatment of patients with persistent diabetic
macular edema in whom laser photocoagulation proved to be ineffective and as a result
they required a monthly injection of anti-VEGF factors (Ranibizumab, Bevacizumab) may
be a good alternative to extending the interval of injections. However, reinjections involve
a high risk of developing poststeroid cataracts, which is not without significance in middle-aged patients. |
| format | Article |
| id | doaj-art-c37ad362498d4dbbabdb46b92a785cfd |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c37ad362498d4dbbabdb46b92a785cfd2025-02-03T06:01:28ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/364143364143Five-Month Observation of Persistent Diabetic Macular Edema after Intravitreal Injection of Ozurdex ImplantDominik Zalewski0Dorota Raczyńska1Krystyna Raczyńska2Diagnostic and Microsurgery Center of the Eye LENS, 3a Budowlana Street, 10-424 Olsztyn, PolandDepartment of Anesthesiology and Intensive Care Medicine and Department of Ophthalmology, Medical University of Gdańsk, 17 Smoluchowskiego Street, 80-952 Gdańsk, PolandDepartment of Ophthalmology, Medical University of Gdańsk, 17 Smoluchowskiego Street, 80-952 Gdańsk, PolandAims. This retrospective analysis was aimed at evaluating the effectiveness of treatment of persistent diabetic macular edema with intravitreal injections of 0.7 mg dexamethasone implant Ozurdex. The study comprised three male patients (6 eyes). Results. The average thickness of the retina at baseline was 632 μm, the medial BCVA was 0.8 logMAR, and corrected intraocular pressure was 13.7 mmHg. The maximum decrease in mean retinal thickness was observed at four weeks following the treatment and was 365 μm (−267 μm) and visual acuity improved by an average of two lines and was 0.6 logMAR. The largest increase in mean retinal thickness to average of 528 μm (+164 μm) occurred at 16 weeks and the average BCVA was 0.614 lines BCVA logMAR. In one eye, there was a steroid cataract development after the third dose of dexamethasone implant of 0.7 mg. Conclusions. The intravitreal dexamethasone implant treatment of patients with persistent diabetic macular edema in whom laser photocoagulation proved to be ineffective and as a result they required a monthly injection of anti-VEGF factors (Ranibizumab, Bevacizumab) may be a good alternative to extending the interval of injections. However, reinjections involve a high risk of developing poststeroid cataracts, which is not without significance in middle-aged patients.http://dx.doi.org/10.1155/2014/364143 |
| spellingShingle | Dominik Zalewski Dorota Raczyńska Krystyna Raczyńska Five-Month Observation of Persistent Diabetic Macular Edema after Intravitreal Injection of Ozurdex Implant Mediators of Inflammation |
| title | Five-Month Observation of Persistent Diabetic Macular Edema after Intravitreal Injection of Ozurdex Implant |
| title_full | Five-Month Observation of Persistent Diabetic Macular Edema after Intravitreal Injection of Ozurdex Implant |
| title_fullStr | Five-Month Observation of Persistent Diabetic Macular Edema after Intravitreal Injection of Ozurdex Implant |
| title_full_unstemmed | Five-Month Observation of Persistent Diabetic Macular Edema after Intravitreal Injection of Ozurdex Implant |
| title_short | Five-Month Observation of Persistent Diabetic Macular Edema after Intravitreal Injection of Ozurdex Implant |
| title_sort | five month observation of persistent diabetic macular edema after intravitreal injection of ozurdex implant |
| url | http://dx.doi.org/10.1155/2014/364143 |
| work_keys_str_mv | AT dominikzalewski fivemonthobservationofpersistentdiabeticmacularedemaafterintravitrealinjectionofozurdeximplant AT dorotaraczynska fivemonthobservationofpersistentdiabeticmacularedemaafterintravitrealinjectionofozurdeximplant AT krystynaraczynska fivemonthobservationofpersistentdiabeticmacularedemaafterintravitrealinjectionofozurdeximplant |