NT-proBNP in Acute De Novo Heart Failure: A Key Biomarker for Predicting Myocardial Recovery—COMFE Registry
This study aims to analyze whether NT-proBNP at admission and discharge in de novo heart failure (HF) with reduced ejection fraction (HFrEF) is associated with myocardial recovery. This is a prospective observational study in two centers. Patients admitted with de novo HFrEF between 2021 and 2023 we...
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| Format: | Article |
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MDPI AG
2025-03-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/15/4/526 |
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| author | Raquel López-Vilella Inés Gómez-Otero Víctor Donoso Trenado David García-Vega Óscar Otero-García Luis Martínez Dolz José Ramón González-Juanatey Luis Almenar Bonet |
| author_facet | Raquel López-Vilella Inés Gómez-Otero Víctor Donoso Trenado David García-Vega Óscar Otero-García Luis Martínez Dolz José Ramón González-Juanatey Luis Almenar Bonet |
| author_sort | Raquel López-Vilella |
| collection | DOAJ |
| description | This study aims to analyze whether NT-proBNP at admission and discharge in de novo heart failure (HF) with reduced ejection fraction (HFrEF) is associated with myocardial recovery. This is a prospective observational study in two centers. Patients admitted with de novo HFrEF between 2021 and 2023 were included. HF with improved ejection fraction (HFimpEF) was defined as an improvement of at least 10 points with an ejection fraction >40%. Of the 248 patients who were included, 63.3% met HFimpEF criteria at follow-up, with no differences in age or gender. There were no differences in NT-proBNP at admission, but there were at discharge, where its value was inversely associated with myocardial recovery (OR 0.99 for each increase in the square root of NT-proBNP, 95% CI 0.98–0.99, <i>p</i> = 0.048). An NT-proBNP > 10,000 pg/mL at discharge was independently associated with reduced ventricular recovery (OR 0.28, 95% CI 0.07–0.94, <i>p</i> = 0.043). A smaller reduction in NT-proBNP during admission decreased the probability of recovery (OR 0.13, 95% CI 0.03–0.61, <i>p</i> = 0.010). In conclusion, in admissions for de novo HFrEF, NT-proBNP at discharge is inversely associated with myocardial recovery; a level > 10,000 pg/mL is an independent predictor for a lack of recovery, while a greater reduction increases the likelihood of recovery. |
| format | Article |
| id | doaj-art-c374cdff0cf647cbbe813abc70e94a52 |
| institution | OA Journals |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-c374cdff0cf647cbbe813abc70e94a522025-08-20T02:18:09ZengMDPI AGLife2075-17292025-03-0115452610.3390/life15040526NT-proBNP in Acute De Novo Heart Failure: A Key Biomarker for Predicting Myocardial Recovery—COMFE RegistryRaquel López-Vilella0Inés Gómez-Otero1Víctor Donoso Trenado2David García-Vega3Óscar Otero-García4Luis Martínez Dolz5José Ramón González-Juanatey6Luis Almenar Bonet7Cardiology Department, Hospital Universitari i Politècnic La Fe, 46026 Valencia, SpainCardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, 15706 Santiago de Compostela, SpainCardiology Department, Hospital Universitari i Politècnic La Fe, 46026 Valencia, SpainCardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, 15706 Santiago de Compostela, SpainCardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, 15706 Santiago de Compostela, SpainHeart Failure and Transplant Unit, Hospital Universitari i Politècnic La Fe, 46026 Valencia, SpainCardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, 15706 Santiago de Compostela, SpainCardiology Department, Hospital Universitari i Politècnic La Fe, 46026 Valencia, SpainThis study aims to analyze whether NT-proBNP at admission and discharge in de novo heart failure (HF) with reduced ejection fraction (HFrEF) is associated with myocardial recovery. This is a prospective observational study in two centers. Patients admitted with de novo HFrEF between 2021 and 2023 were included. HF with improved ejection fraction (HFimpEF) was defined as an improvement of at least 10 points with an ejection fraction >40%. Of the 248 patients who were included, 63.3% met HFimpEF criteria at follow-up, with no differences in age or gender. There were no differences in NT-proBNP at admission, but there were at discharge, where its value was inversely associated with myocardial recovery (OR 0.99 for each increase in the square root of NT-proBNP, 95% CI 0.98–0.99, <i>p</i> = 0.048). An NT-proBNP > 10,000 pg/mL at discharge was independently associated with reduced ventricular recovery (OR 0.28, 95% CI 0.07–0.94, <i>p</i> = 0.043). A smaller reduction in NT-proBNP during admission decreased the probability of recovery (OR 0.13, 95% CI 0.03–0.61, <i>p</i> = 0.010). In conclusion, in admissions for de novo HFrEF, NT-proBNP at discharge is inversely associated with myocardial recovery; a level > 10,000 pg/mL is an independent predictor for a lack of recovery, while a greater reduction increases the likelihood of recovery.https://www.mdpi.com/2075-1729/15/4/526de novo heart failureimproved ejection fractionNT-proBNPmyocardial recovery |
| spellingShingle | Raquel López-Vilella Inés Gómez-Otero Víctor Donoso Trenado David García-Vega Óscar Otero-García Luis Martínez Dolz José Ramón González-Juanatey Luis Almenar Bonet NT-proBNP in Acute De Novo Heart Failure: A Key Biomarker for Predicting Myocardial Recovery—COMFE Registry Life de novo heart failure improved ejection fraction NT-proBNP myocardial recovery |
| title | NT-proBNP in Acute De Novo Heart Failure: A Key Biomarker for Predicting Myocardial Recovery—COMFE Registry |
| title_full | NT-proBNP in Acute De Novo Heart Failure: A Key Biomarker for Predicting Myocardial Recovery—COMFE Registry |
| title_fullStr | NT-proBNP in Acute De Novo Heart Failure: A Key Biomarker for Predicting Myocardial Recovery—COMFE Registry |
| title_full_unstemmed | NT-proBNP in Acute De Novo Heart Failure: A Key Biomarker for Predicting Myocardial Recovery—COMFE Registry |
| title_short | NT-proBNP in Acute De Novo Heart Failure: A Key Biomarker for Predicting Myocardial Recovery—COMFE Registry |
| title_sort | nt probnp in acute de novo heart failure a key biomarker for predicting myocardial recovery comfe registry |
| topic | de novo heart failure improved ejection fraction NT-proBNP myocardial recovery |
| url | https://www.mdpi.com/2075-1729/15/4/526 |
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