An Efficient Synthesis of a Variety of Substituted Pyridine-3-Thiols
A practical and convenient method for the synthesis of pyridine-3-thiols using substituted 3-iodopyridines as starting compounds has been developed. Based on the use of thiobenzoic acid as a sulfur donor in a two-step procedure, this approach made it possible to synthesize a number of pyridine-3-thi...
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| Format: | Article |
| Language: | English |
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National University of Pharmacy (Kharkiv)
2025-04-01
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| Series: | Журнал органічної та фармацевтичної хімії |
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| Online Access: | https://ophcj.nuph.edu.ua/article/view/324523 |
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| author | Oleksandr V. Borysov Dmytro P. Bohdan |
| author_facet | Oleksandr V. Borysov Dmytro P. Bohdan |
| author_sort | Oleksandr V. Borysov |
| collection | DOAJ |
| description | A practical and convenient method for the synthesis of pyridine-3-thiols using substituted 3-iodopyridines as starting compounds has been developed. Based on the use of thiobenzoic acid as a sulfur donor in a two-step procedure, this approach made it possible to synthesize a number of pyridine-3-thiols with F, Cl, Br, CH3, OCH3 substituents at various positions of the pyridine ring. The procedure presented gives high yields of the target products with a purity of 95% and is suitable for synthesis in tens of grams. |
| format | Article |
| id | doaj-art-c36df18c7fc64dfc9cf80739089e71d3 |
| institution | Kabale University |
| issn | 2308-8303 2518-1548 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | National University of Pharmacy (Kharkiv) |
| record_format | Article |
| series | Журнал органічної та фармацевтичної хімії |
| spelling | doaj-art-c36df18c7fc64dfc9cf80739089e71d32025-08-20T03:29:24ZengNational University of Pharmacy (Kharkiv)Журнал органічної та фармацевтичної хімії2308-83032518-15482025-04-01231434810.24959/ophcj.25.324523An Efficient Synthesis of a Variety of Substituted Pyridine-3-ThiolsOleksandr V. Borysov0https://orcid.org/0000-0003-0360-9295Dmytro P. Bohdan1Institute of Organic Chemistry of the National Academy of Sciences of Ukraine; Enamine Ltd., UkraineInstitute of Organic Chemistry of the National Academy of Sciences of Ukraine, UkraineA practical and convenient method for the synthesis of pyridine-3-thiols using substituted 3-iodopyridines as starting compounds has been developed. Based on the use of thiobenzoic acid as a sulfur donor in a two-step procedure, this approach made it possible to synthesize a number of pyridine-3-thiols with F, Cl, Br, CH3, OCH3 substituents at various positions of the pyridine ring. The procedure presented gives high yields of the target products with a purity of 95% and is suitable for synthesis in tens of grams.https://ophcj.nuph.edu.ua/article/view/324523pyridinethiolsthiobenzoic acidchromatographyhydrolysis |
| spellingShingle | Oleksandr V. Borysov Dmytro P. Bohdan An Efficient Synthesis of a Variety of Substituted Pyridine-3-Thiols Журнал органічної та фармацевтичної хімії pyridine thiols thiobenzoic acid chromatography hydrolysis |
| title | An Efficient Synthesis of a Variety of Substituted Pyridine-3-Thiols |
| title_full | An Efficient Synthesis of a Variety of Substituted Pyridine-3-Thiols |
| title_fullStr | An Efficient Synthesis of a Variety of Substituted Pyridine-3-Thiols |
| title_full_unstemmed | An Efficient Synthesis of a Variety of Substituted Pyridine-3-Thiols |
| title_short | An Efficient Synthesis of a Variety of Substituted Pyridine-3-Thiols |
| title_sort | efficient synthesis of a variety of substituted pyridine 3 thiols |
| topic | pyridine thiols thiobenzoic acid chromatography hydrolysis |
| url | https://ophcj.nuph.edu.ua/article/view/324523 |
| work_keys_str_mv | AT oleksandrvborysov anefficientsynthesisofavarietyofsubstitutedpyridine3thiols AT dmytropbohdan anefficientsynthesisofavarietyofsubstitutedpyridine3thiols AT oleksandrvborysov efficientsynthesisofavarietyofsubstitutedpyridine3thiols AT dmytropbohdan efficientsynthesisofavarietyofsubstitutedpyridine3thiols |