CRISPR-Cas9-based approaches for genetic analysis and epistatic interaction studies in Coxiella burnetii

CRISPR-Cas9-based approaches for genetic analysis and epistatic interaction studies in Coxiella burnetii

ABSTRACT Coxiella burnetii is an obligate intracellular bacterial pathogen that replicates to high numbers in an acidified lysosome-derived vacuole. Intracellular replication requires the Dot/Icm type IVB secretion system, which translocates over 100 different effector proteins into the host cell. S...

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Bibliographic Details
Main Authors: Samuel Steiner, Craig R. Roy
Format: Article
Language:English
Published: American Society for Microbiology 2024-12-01
Series:mSphere
Subjects:
Coxiella burnetii
base editing
CRISPR
CRISPRi
intracellular infection
Online Access:https://journals.asm.org/doi/10.1128/msphere.00523-24
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