Satellite Cells: Regenerative Mechanisms and Applicability in Muscular Dystrophy
The satellite cells are long regarded as heterogeneous cell population, which is intimately linked to the processes of muscular recovery. The heterogeneous cell population may be classified by specific markers. In spite of the significant amount of variation amongst the satellite cell populations, i...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/487467 |
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| author | Gustavo Torres de Souza Rafaella de Souza Salomão Zanette Danielle Luciana Aurora Soares do Amaral Francisco Carlos da Guia Claudinéia Pereira Maranduba Camila Maurmann de Souza Ernesto da Silveira Goulart Guimarães João Vitor Paes Rettore Natana Chaves Rabelo Antônio Márcio Resende do Carmo Fernando de Sá Silva Carlos Magno da Costa Maranduba |
| author_facet | Gustavo Torres de Souza Rafaella de Souza Salomão Zanette Danielle Luciana Aurora Soares do Amaral Francisco Carlos da Guia Claudinéia Pereira Maranduba Camila Maurmann de Souza Ernesto da Silveira Goulart Guimarães João Vitor Paes Rettore Natana Chaves Rabelo Antônio Márcio Resende do Carmo Fernando de Sá Silva Carlos Magno da Costa Maranduba |
| author_sort | Gustavo Torres de Souza |
| collection | DOAJ |
| description | The satellite cells are long regarded as heterogeneous cell population, which is intimately linked to the processes of muscular recovery. The heterogeneous cell population may be classified by specific markers. In spite of the significant amount of variation amongst the satellite cell populations, it seems that their activity is tightly bound to the paired box 7 transcription factor expression, which is, therefore, used as a canonical marker for these cells. Muscular dystrophic diseases, such as Duchenne muscular dystrophy, elicit severe tissue injuries leading those patients to display a very specific pattern of muscular recovery abnormalities. There have been works on the application of precursors cells as a therapeutic alternative for Duchenne muscular dystrophy and initial attempts have proven the cells inefficient; however later endeavours have proposed solutions for the experiments improving significantly the results. The presence of a range of satellite cells populations indicates the existence of specific cells with enhanced capability of muscular recovery in afflicted muscles. |
| format | Article |
| id | doaj-art-c365fc1cd6e5435db1c362ecfde90ae2 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-c365fc1cd6e5435db1c362ecfde90ae22025-02-03T01:09:00ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/487467487467Satellite Cells: Regenerative Mechanisms and Applicability in Muscular DystrophyGustavo Torres de Souza0Rafaella de Souza Salomão Zanette1Danielle Luciana Aurora Soares do Amaral2Francisco Carlos da Guia3Claudinéia Pereira Maranduba4Camila Maurmann de Souza5Ernesto da Silveira Goulart Guimarães6João Vitor Paes Rettore7Natana Chaves Rabelo8Antônio Márcio Resende do Carmo9Fernando de Sá Silva10Carlos Magno da Costa Maranduba11Laboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilLaboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilLaboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilLaboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilLaboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilLaboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilLaboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilLaboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilLaboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilDepartment of Endodontology, Dentistry School, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilLaboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilLaboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, 36036-900 Juiz de Fora, MG, BrazilThe satellite cells are long regarded as heterogeneous cell population, which is intimately linked to the processes of muscular recovery. The heterogeneous cell population may be classified by specific markers. In spite of the significant amount of variation amongst the satellite cell populations, it seems that their activity is tightly bound to the paired box 7 transcription factor expression, which is, therefore, used as a canonical marker for these cells. Muscular dystrophic diseases, such as Duchenne muscular dystrophy, elicit severe tissue injuries leading those patients to display a very specific pattern of muscular recovery abnormalities. There have been works on the application of precursors cells as a therapeutic alternative for Duchenne muscular dystrophy and initial attempts have proven the cells inefficient; however later endeavours have proposed solutions for the experiments improving significantly the results. The presence of a range of satellite cells populations indicates the existence of specific cells with enhanced capability of muscular recovery in afflicted muscles.http://dx.doi.org/10.1155/2015/487467 |
| spellingShingle | Gustavo Torres de Souza Rafaella de Souza Salomão Zanette Danielle Luciana Aurora Soares do Amaral Francisco Carlos da Guia Claudinéia Pereira Maranduba Camila Maurmann de Souza Ernesto da Silveira Goulart Guimarães João Vitor Paes Rettore Natana Chaves Rabelo Antônio Márcio Resende do Carmo Fernando de Sá Silva Carlos Magno da Costa Maranduba Satellite Cells: Regenerative Mechanisms and Applicability in Muscular Dystrophy Stem Cells International |
| title | Satellite Cells: Regenerative Mechanisms and Applicability in Muscular Dystrophy |
| title_full | Satellite Cells: Regenerative Mechanisms and Applicability in Muscular Dystrophy |
| title_fullStr | Satellite Cells: Regenerative Mechanisms and Applicability in Muscular Dystrophy |
| title_full_unstemmed | Satellite Cells: Regenerative Mechanisms and Applicability in Muscular Dystrophy |
| title_short | Satellite Cells: Regenerative Mechanisms and Applicability in Muscular Dystrophy |
| title_sort | satellite cells regenerative mechanisms and applicability in muscular dystrophy |
| url | http://dx.doi.org/10.1155/2015/487467 |
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