The interplay between persistent pathogen infections with tumor microenvironment and immunotherapy in cancer
Abstract Background Chronic infections by pathogenic microorganisms play a significant role in cancer development, disrupting the body's immune system and microenvironment. This interference impairs the body's ability to eliminate these microorganisms promptly, allowing them to persist by...
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| Format: | Article |
| Language: | English |
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Wiley
2024-09-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.70154 |
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| _version_ | 1825206512980590592 |
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| author | Si Chen Caihong Yao Na Tian Chunying Zhang Yuemei Chen Xuting Wang Yue Jiang Tonghao Zhang Tingting Zeng Yali Song |
| author_facet | Si Chen Caihong Yao Na Tian Chunying Zhang Yuemei Chen Xuting Wang Yue Jiang Tonghao Zhang Tingting Zeng Yali Song |
| author_sort | Si Chen |
| collection | DOAJ |
| description | Abstract Background Chronic infections by pathogenic microorganisms play a significant role in cancer development, disrupting the body's immune system and microenvironment. This interference impairs the body's ability to eliminate these microorganisms promptly, allowing them to persist by evading immune defenses. Aims This study aimed to explore how chronic pathogenic infections influence the immune microenvironment, impacting tumorigenesis, cancer progression, and treatment strategies. Additionally, it seeks to investigate the effects of these infections on specific immune checkpoints and identify potential targets for immunotherapy. Methods We conducted searches, readings, and detailed analyses of key terms in databases like PubMed and Web of Science to evaluate the impact of chronic infections by pathogenic microorganisms on the immune microenvironment. Results Our analysis demonstrates a significant association between persistent chronic infections by pathogenic microorganisms and tumorigenesis. Notable impacts on the immune microenvironment include changes in immune cell function and the regulation of immune checkpoints, offering insights into potential targets for cancer immunotherapy. Discussion This study highlights the complex relationship between chronic infections and cancer development, presenting new opportunities for cancer immunotherapy by understanding their effects on the immune microenvironment. The influence of these infections on immune checkpoints emphasizes the crucial role of the immune system in cancer treatment. Conclusion Chronic infections by pathogenic microorganisms greatly affect the immune microenvironment, tumorigenesis, and cancer treatment. Unraveling the underlying mechanisms can unveil potential targets for immunotherapy, improving our comprehension of the immune response to cancer and potentially leading to more effective cancer treatments in the future. |
| format | Article |
| id | doaj-art-c365bf18230f4966ab3992b1b1abd194 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-c365bf18230f4966ab3992b1b1abd1942025-02-07T09:08:08ZengWileyCancer Medicine2045-76342024-09-011317n/an/a10.1002/cam4.70154The interplay between persistent pathogen infections with tumor microenvironment and immunotherapy in cancerSi Chen0Caihong Yao1Na Tian2Chunying Zhang3Yuemei Chen4Xuting Wang5Yue Jiang6Tonghao Zhang7Tingting Zeng8Yali Song9Department of Laboratory Medicine West China Hospital, Sichuan University; Sichuan Clinical Research Center for Laboratory Medicine; Clinical Laboratory Medicine Research Center of West China Hospital Chengdu People's Republic of ChinaDepartment of Laboratory Medicine West China Hospital, Sichuan University; Sichuan Clinical Research Center for Laboratory Medicine; Clinical Laboratory Medicine Research Center of West China Hospital Chengdu People's Republic of ChinaAnesthesiology Department Qingdao Eighth People's Hospital Qingdao People's Republic of ChinaDepartment of Laboratory Medicine West China Hospital, Sichuan University; Sichuan Clinical Research Center for Laboratory Medicine; Clinical Laboratory Medicine Research Center of West China Hospital Chengdu People's Republic of ChinaDepartment of Laboratory Medicine West China Hospital, Sichuan University; Sichuan Clinical Research Center for Laboratory Medicine; Clinical Laboratory Medicine Research Center of West China Hospital Chengdu People's Republic of ChinaDepartment of Laboratory Medicine West China Hospital, Sichuan University; Sichuan Clinical Research Center for Laboratory Medicine; Clinical Laboratory Medicine Research Center of West China Hospital Chengdu People's Republic of ChinaDepartment of Laboratory Medicine West China Hospital, Sichuan University; Sichuan Clinical Research Center for Laboratory Medicine; Clinical Laboratory Medicine Research Center of West China Hospital Chengdu People's Republic of ChinaDepartment of Statistics University of Virginia Charlottesville Virginia USADepartment of Laboratory Medicine West China Hospital, Sichuan University; Sichuan Clinical Research Center for Laboratory Medicine; Clinical Laboratory Medicine Research Center of West China Hospital Chengdu People's Republic of ChinaDepartment of Laboratory Medicine West China Hospital, Sichuan University; Sichuan Clinical Research Center for Laboratory Medicine; Clinical Laboratory Medicine Research Center of West China Hospital Chengdu People's Republic of ChinaAbstract Background Chronic infections by pathogenic microorganisms play a significant role in cancer development, disrupting the body's immune system and microenvironment. This interference impairs the body's ability to eliminate these microorganisms promptly, allowing them to persist by evading immune defenses. Aims This study aimed to explore how chronic pathogenic infections influence the immune microenvironment, impacting tumorigenesis, cancer progression, and treatment strategies. Additionally, it seeks to investigate the effects of these infections on specific immune checkpoints and identify potential targets for immunotherapy. Methods We conducted searches, readings, and detailed analyses of key terms in databases like PubMed and Web of Science to evaluate the impact of chronic infections by pathogenic microorganisms on the immune microenvironment. Results Our analysis demonstrates a significant association between persistent chronic infections by pathogenic microorganisms and tumorigenesis. Notable impacts on the immune microenvironment include changes in immune cell function and the regulation of immune checkpoints, offering insights into potential targets for cancer immunotherapy. Discussion This study highlights the complex relationship between chronic infections and cancer development, presenting new opportunities for cancer immunotherapy by understanding their effects on the immune microenvironment. The influence of these infections on immune checkpoints emphasizes the crucial role of the immune system in cancer treatment. Conclusion Chronic infections by pathogenic microorganisms greatly affect the immune microenvironment, tumorigenesis, and cancer treatment. Unraveling the underlying mechanisms can unveil potential targets for immunotherapy, improving our comprehension of the immune response to cancer and potentially leading to more effective cancer treatments in the future.https://doi.org/10.1002/cam4.70154cancerchronic infectionsimmunotherapytumor microenvironment |
| spellingShingle | Si Chen Caihong Yao Na Tian Chunying Zhang Yuemei Chen Xuting Wang Yue Jiang Tonghao Zhang Tingting Zeng Yali Song The interplay between persistent pathogen infections with tumor microenvironment and immunotherapy in cancer Cancer Medicine cancer chronic infections immunotherapy tumor microenvironment |
| title | The interplay between persistent pathogen infections with tumor microenvironment and immunotherapy in cancer |
| title_full | The interplay between persistent pathogen infections with tumor microenvironment and immunotherapy in cancer |
| title_fullStr | The interplay between persistent pathogen infections with tumor microenvironment and immunotherapy in cancer |
| title_full_unstemmed | The interplay between persistent pathogen infections with tumor microenvironment and immunotherapy in cancer |
| title_short | The interplay between persistent pathogen infections with tumor microenvironment and immunotherapy in cancer |
| title_sort | interplay between persistent pathogen infections with tumor microenvironment and immunotherapy in cancer |
| topic | cancer chronic infections immunotherapy tumor microenvironment |
| url | https://doi.org/10.1002/cam4.70154 |
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