Parkinson’s Disease and Cognitive Impairment
Parkinson’s disease (PD) is a progressive neurodegenerative disease primarily characterized by the hallmarks of motor symptoms, such as tremor, bradykinesia, rigidity, and postural instability. However, through clinical investigations in patients and experimental findings in animal models of Parkins...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2016/6734678 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850177671860846592 |
|---|---|
| author | Yang Yang Bei-sha Tang Ji-feng Guo |
| author_facet | Yang Yang Bei-sha Tang Ji-feng Guo |
| author_sort | Yang Yang |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is a progressive neurodegenerative disease primarily characterized by the hallmarks of motor symptoms, such as tremor, bradykinesia, rigidity, and postural instability. However, through clinical investigations in patients and experimental findings in animal models of Parkinson’s disease for years, it is now well recognized that Parkinson’s disease is more than just a motor-deficit disorder. The majority of Parkinson’s disease patients suffer from nonmotor disabilities, for instance, cognitive impairment, autonomic dysfunction, sensory dysfunction, and sleep disorder. So far, anti-PD prescriptions and surgical treatments have been mainly focusing on motor dysfunctions, leaving cognitive impairment a marginal clinical field. Within the nonmotor symptoms, cognitive impairment is one of the most common and significant aspects of Parkinson’s disease, and cognitive deficits such as dysexecutive syndrome and visuospatial disturbances could seriously affect the quality of life, reduce life expectancy, prolong the duration of hospitalization, and therefore increase burdens of caregiver and medical costs. In this review, we have done a retrospective study of the recent related researches on epidemiology, clinical manifestation and diagnosis, genetics, and potential treatment of cognitive deficits in Parkinson’s disease, aiming to provide a summary of cognitive impairment in Parkinson’s disease and make it easy for clinicians to tackle this challenging issue in their future practice. |
| format | Article |
| id | doaj-art-c3618807d0754b9b93f7ff99a34eefc5 |
| institution | OA Journals |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-c3618807d0754b9b93f7ff99a34eefc52025-08-20T02:18:55ZengWileyParkinson's Disease2090-80832042-00802016-01-01201610.1155/2016/67346786734678Parkinson’s Disease and Cognitive ImpairmentYang Yang0Bei-sha Tang1Ji-feng Guo2Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, ChinaParkinson’s disease (PD) is a progressive neurodegenerative disease primarily characterized by the hallmarks of motor symptoms, such as tremor, bradykinesia, rigidity, and postural instability. However, through clinical investigations in patients and experimental findings in animal models of Parkinson’s disease for years, it is now well recognized that Parkinson’s disease is more than just a motor-deficit disorder. The majority of Parkinson’s disease patients suffer from nonmotor disabilities, for instance, cognitive impairment, autonomic dysfunction, sensory dysfunction, and sleep disorder. So far, anti-PD prescriptions and surgical treatments have been mainly focusing on motor dysfunctions, leaving cognitive impairment a marginal clinical field. Within the nonmotor symptoms, cognitive impairment is one of the most common and significant aspects of Parkinson’s disease, and cognitive deficits such as dysexecutive syndrome and visuospatial disturbances could seriously affect the quality of life, reduce life expectancy, prolong the duration of hospitalization, and therefore increase burdens of caregiver and medical costs. In this review, we have done a retrospective study of the recent related researches on epidemiology, clinical manifestation and diagnosis, genetics, and potential treatment of cognitive deficits in Parkinson’s disease, aiming to provide a summary of cognitive impairment in Parkinson’s disease and make it easy for clinicians to tackle this challenging issue in their future practice.http://dx.doi.org/10.1155/2016/6734678 |
| spellingShingle | Yang Yang Bei-sha Tang Ji-feng Guo Parkinson’s Disease and Cognitive Impairment Parkinson's Disease |
| title | Parkinson’s Disease and Cognitive Impairment |
| title_full | Parkinson’s Disease and Cognitive Impairment |
| title_fullStr | Parkinson’s Disease and Cognitive Impairment |
| title_full_unstemmed | Parkinson’s Disease and Cognitive Impairment |
| title_short | Parkinson’s Disease and Cognitive Impairment |
| title_sort | parkinson s disease and cognitive impairment |
| url | http://dx.doi.org/10.1155/2016/6734678 |
| work_keys_str_mv | AT yangyang parkinsonsdiseaseandcognitiveimpairment AT beishatang parkinsonsdiseaseandcognitiveimpairment AT jifengguo parkinsonsdiseaseandcognitiveimpairment |