Clinical, Hematological and Immunophenotypic Profiles in Chronic Lymphocytic Leukemia in Kurdistan-Iraq
Background and objectives: Chronic lymphocytic leukemia is the accumulation of morphologically mature lymphocytes in blood and lymphatic tissues. We aimed to outline the clinical-hematological and immunophenotypic patterns of patients with chronic lymphocytic leukemia in Kurdistan-Iraq. Methods:...
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Kurdistan Higher Council Of Medical Specialties
2022-06-01
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| Series: | Advanced Medical Journal |
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| Online Access: | https://amj.khcms.edu.krd/index.php/main/article/view/20 |
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| author | Dr. Dashne Jamal Rasheed Dr. Sana Dlawar Jalal Dr. Ahmed Kudair Yassin |
| author_facet | Dr. Dashne Jamal Rasheed Dr. Sana Dlawar Jalal Dr. Ahmed Kudair Yassin |
| author_sort | Dr. Dashne Jamal Rasheed |
| collection | DOAJ |
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Background and objectives: Chronic lymphocytic leukemia is the accumulation of morphologically mature lymphocytes in blood and lymphatic tissues. We aimed to outline the clinical-hematological and immunophenotypic patterns of patients with chronic lymphocytic leukemia in Kurdistan-Iraq.
Methods: This is a retrospective cohort study on 154 patients referred to Sulaimani Public Health Lab and Nanakaly Hospital - Hawler from January 1st, 2013 to December 31st, 2017 and diagnosed with chronic lymphocytic leukemia. Demographic, clinical, and laboratory data were recorded. Clinical stages and immunological scoring were determined.
Results: Median patient age at diagnosis was 70 years with a range of 39-82 and a male: female ratio of 1.8:1. Thirty five patients (22.7%) were diagnosed incidentally, and 85 (55.2%) had B-symptoms at presentation. Lymphadenopathy was the most common presenting feature, seen in 84 (54.6%) patients ,while splenomegaly reported in 40 ( 26%)patients and hepatomegaly in 7(4.6) patients. Forty four (28.6%) patients had anemia at diagnosis, while 150(97.3%) patients presented with leukocytosis, and 21(13.6%) patients had thrombocytopenia. Leukemic B-cells have a specific immunophenotypic profile: CD19, CD20 weak, CD22 weak, CD5 bright, CD23+, CD79bweak, FMC7 weak/-, CD200 and weak immunoglobulin light chain restriction. The applied scoring system revealed that 112 (72.7%) patients scored four and the rest scored five out of five. Moreover, sixty five (42.2%) patients presented with advanced Rai stage and 62(40.3%) patients presented with stage C Binet system.
Conclusions: Patients characteristics were not distinct from those reported elsewhere, though a higher proportion of our patients presented with an advanced clinical stage.
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| format | Article |
| id | doaj-art-c360ef6e3e1940a38efd0770360fa9d3 |
| institution | OA Journals |
| issn | 2958-8979 2957-3580 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | Kurdistan Higher Council Of Medical Specialties |
| record_format | Article |
| series | Advanced Medical Journal |
| spelling | doaj-art-c360ef6e3e1940a38efd0770360fa9d32025-08-20T02:27:31ZengKurdistan Higher Council Of Medical SpecialtiesAdvanced Medical Journal2958-89792957-35802022-06-016210.56056/amj.2022.13820Clinical, Hematological and Immunophenotypic Profiles in Chronic Lymphocytic Leukemia in Kurdistan-IraqDr. Dashne Jamal Rasheed0Dr. Sana Dlawar Jalal1Dr. Ahmed Kudair Yassin2MBChB, Senior registrar, Sulaimani Thalassemia CenterMBChB, FRCPath, Assistant professor of hematology, Department of pathology, College of Medicine, University of SulaimaniMBChB, FRCP, Consultant clinical hematologist, Department of Medicine, Hawler Medical University, College of Medicine Background and objectives: Chronic lymphocytic leukemia is the accumulation of morphologically mature lymphocytes in blood and lymphatic tissues. We aimed to outline the clinical-hematological and immunophenotypic patterns of patients with chronic lymphocytic leukemia in Kurdistan-Iraq. Methods: This is a retrospective cohort study on 154 patients referred to Sulaimani Public Health Lab and Nanakaly Hospital - Hawler from January 1st, 2013 to December 31st, 2017 and diagnosed with chronic lymphocytic leukemia. Demographic, clinical, and laboratory data were recorded. Clinical stages and immunological scoring were determined. Results: Median patient age at diagnosis was 70 years with a range of 39-82 and a male: female ratio of 1.8:1. Thirty five patients (22.7%) were diagnosed incidentally, and 85 (55.2%) had B-symptoms at presentation. Lymphadenopathy was the most common presenting feature, seen in 84 (54.6%) patients ,while splenomegaly reported in 40 ( 26%)patients and hepatomegaly in 7(4.6) patients. Forty four (28.6%) patients had anemia at diagnosis, while 150(97.3%) patients presented with leukocytosis, and 21(13.6%) patients had thrombocytopenia. Leukemic B-cells have a specific immunophenotypic profile: CD19, CD20 weak, CD22 weak, CD5 bright, CD23+, CD79bweak, FMC7 weak/-, CD200 and weak immunoglobulin light chain restriction. The applied scoring system revealed that 112 (72.7%) patients scored four and the rest scored five out of five. Moreover, sixty five (42.2%) patients presented with advanced Rai stage and 62(40.3%) patients presented with stage C Binet system. Conclusions: Patients characteristics were not distinct from those reported elsewhere, though a higher proportion of our patients presented with an advanced clinical stage. https://amj.khcms.edu.krd/index.php/main/article/view/20Chronic lymphocytic leukemiaStagingFlow cytometry |
| spellingShingle | Dr. Dashne Jamal Rasheed Dr. Sana Dlawar Jalal Dr. Ahmed Kudair Yassin Clinical, Hematological and Immunophenotypic Profiles in Chronic Lymphocytic Leukemia in Kurdistan-Iraq Advanced Medical Journal Chronic lymphocytic leukemia Staging Flow cytometry |
| title | Clinical, Hematological and Immunophenotypic Profiles in Chronic Lymphocytic Leukemia in Kurdistan-Iraq |
| title_full | Clinical, Hematological and Immunophenotypic Profiles in Chronic Lymphocytic Leukemia in Kurdistan-Iraq |
| title_fullStr | Clinical, Hematological and Immunophenotypic Profiles in Chronic Lymphocytic Leukemia in Kurdistan-Iraq |
| title_full_unstemmed | Clinical, Hematological and Immunophenotypic Profiles in Chronic Lymphocytic Leukemia in Kurdistan-Iraq |
| title_short | Clinical, Hematological and Immunophenotypic Profiles in Chronic Lymphocytic Leukemia in Kurdistan-Iraq |
| title_sort | clinical hematological and immunophenotypic profiles in chronic lymphocytic leukemia in kurdistan iraq |
| topic | Chronic lymphocytic leukemia Staging Flow cytometry |
| url | https://amj.khcms.edu.krd/index.php/main/article/view/20 |
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