Genomic changes of Lassa virus associated with mammalian host adaptation

Genomic changes of Lassa virus associated with mammalian host adaptation

Abstract Background Lassa virus (LASV) causes a severe haemorrhagic fever in humans, with estimates of 100,000 to 300,000 infections annually in endemic regions and accounting for around 5000 deaths. The natural reservoir is the Mastomys rat, but through zoonotic transmissions humans are accidental...

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Bibliographic Details
Main Authors: Linda Easterbrook, Xiaofeng Dong, Jack Smith, Susan Fotheringham, Sarah Kempster, Catherine Hartley, Tessa Prince, Victoria Graham, Emma Kennedy, Stephen Findlay-Wilson, Lucy Crossley, Roger Hewson, Neil Almond, Julian A. Hiscox, Stuart Dowall
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Genomics
Subjects:
Lassa virus
Adaptation
Passage
Mutation
Changes
Online Access:https://doi.org/10.1186/s12864-025-11666-y
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