Lipid profiles in major depression, both with and without metabolic syndrome: associations with suicidal behaviors and neuroticism
Abstract Background Significant associations exist between major depressive disorder (MDD), metabolic syndrome (MetS), and cardiovascular disease, potentially attributable to heightened atherogenicity. This study aimed to ascertain if MDD, depression severity, suicidal behaviors, and neuroticism ass...
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2025-04-01
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| Online Access: | https://doi.org/10.1186/s12888-025-06734-2 |
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| author | Ketsupar Jirakran Asara Vasupanrajit Chavit Tunvirachaisakul Abbas F. Almulla Marta Kubera Michael Maes |
| author_facet | Ketsupar Jirakran Asara Vasupanrajit Chavit Tunvirachaisakul Abbas F. Almulla Marta Kubera Michael Maes |
| author_sort | Ketsupar Jirakran |
| collection | DOAJ |
| description | Abstract Background Significant associations exist between major depressive disorder (MDD), metabolic syndrome (MetS), and cardiovascular disease, potentially attributable to heightened atherogenicity. This study aimed to ascertain if MDD, depression severity, suicidal behaviors, and neuroticism associate with elevated pro-atherogenic indices and reduced anti-atherogenic indices, including a reverse cholesterol transport (RCT) index. Methods This study comprised 34 healthy controls and 33 MDD patients without MetS, and 35 controls and 31 MDD patients with MetS. It assessed total cholesterol (TC) and free cholesterol (FC), high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc), triglycerides (TG), apolipoprotein (ApoA), ApoB, cholesterol esterification rate, and a RCT composite. Results No significant associations between MDD and lipids were seen in the total study group that combined individuals with and without MetS. In individuals devoid of MetS, MDD is significantly correlated with (a) elevated FC, TG, ApoB, Castelli risk index 1, and ApoB/ApoA, and (b) diminished HDLc, ApoA, and RCT index. In individuals without MetS, there are notable correlations between the severity of depression, suicidal tendencies, neuroticism, and ApoB/ApoA, Castelli risk, and RCT indices. Conclusions The link between lipids and MDD features cannot be adequately estimated by combining participants with and without MetS. It should be examined in a study sample that excludes subjects with MetS. The depression phenome, suicidal behaviors, and neuroticism correlate with diminished RCT and heightened atherogenicity, which are likely implicated in the pathophysiology of MDD. Increased atherogenicity and lowered RCT may represent novel drug targets for the treatment and prevention of MDD, neuroticism, and suicidal behaviors. |
| format | Article |
| id | doaj-art-c3549c483b8e4ae7aeea4e37efff8cb8 |
| institution | OA Journals |
| issn | 1471-244X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj-art-c3549c483b8e4ae7aeea4e37efff8cb82025-08-20T02:28:10ZengBMCBMC Psychiatry1471-244X2025-04-0125111610.1186/s12888-025-06734-2Lipid profiles in major depression, both with and without metabolic syndrome: associations with suicidal behaviors and neuroticismKetsupar Jirakran0Asara Vasupanrajit1Chavit Tunvirachaisakul2Abbas F. Almulla3Marta Kubera4Michael Maes5School of Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Psychiatry, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, the, Thai Red Cross Societyaq Department of Psychiatry, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, the, Thai Red Cross Societyaq School of Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Experimental Neuroendocrinology, Laboratory of Immunoendocrinology, Polish Academy of Sciences, Maj Institute of PharmacologySchool of Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaAbstract Background Significant associations exist between major depressive disorder (MDD), metabolic syndrome (MetS), and cardiovascular disease, potentially attributable to heightened atherogenicity. This study aimed to ascertain if MDD, depression severity, suicidal behaviors, and neuroticism associate with elevated pro-atherogenic indices and reduced anti-atherogenic indices, including a reverse cholesterol transport (RCT) index. Methods This study comprised 34 healthy controls and 33 MDD patients without MetS, and 35 controls and 31 MDD patients with MetS. It assessed total cholesterol (TC) and free cholesterol (FC), high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc), triglycerides (TG), apolipoprotein (ApoA), ApoB, cholesterol esterification rate, and a RCT composite. Results No significant associations between MDD and lipids were seen in the total study group that combined individuals with and without MetS. In individuals devoid of MetS, MDD is significantly correlated with (a) elevated FC, TG, ApoB, Castelli risk index 1, and ApoB/ApoA, and (b) diminished HDLc, ApoA, and RCT index. In individuals without MetS, there are notable correlations between the severity of depression, suicidal tendencies, neuroticism, and ApoB/ApoA, Castelli risk, and RCT indices. Conclusions The link between lipids and MDD features cannot be adequately estimated by combining participants with and without MetS. It should be examined in a study sample that excludes subjects with MetS. The depression phenome, suicidal behaviors, and neuroticism correlate with diminished RCT and heightened atherogenicity, which are likely implicated in the pathophysiology of MDD. Increased atherogenicity and lowered RCT may represent novel drug targets for the treatment and prevention of MDD, neuroticism, and suicidal behaviors.https://doi.org/10.1186/s12888-025-06734-2Major depressionLipidsReverse cholesterol transportMood disordersAtherogenicityCardiovascular disease |
| spellingShingle | Ketsupar Jirakran Asara Vasupanrajit Chavit Tunvirachaisakul Abbas F. Almulla Marta Kubera Michael Maes Lipid profiles in major depression, both with and without metabolic syndrome: associations with suicidal behaviors and neuroticism BMC Psychiatry Major depression Lipids Reverse cholesterol transport Mood disorders Atherogenicity Cardiovascular disease |
| title | Lipid profiles in major depression, both with and without metabolic syndrome: associations with suicidal behaviors and neuroticism |
| title_full | Lipid profiles in major depression, both with and without metabolic syndrome: associations with suicidal behaviors and neuroticism |
| title_fullStr | Lipid profiles in major depression, both with and without metabolic syndrome: associations with suicidal behaviors and neuroticism |
| title_full_unstemmed | Lipid profiles in major depression, both with and without metabolic syndrome: associations with suicidal behaviors and neuroticism |
| title_short | Lipid profiles in major depression, both with and without metabolic syndrome: associations with suicidal behaviors and neuroticism |
| title_sort | lipid profiles in major depression both with and without metabolic syndrome associations with suicidal behaviors and neuroticism |
| topic | Major depression Lipids Reverse cholesterol transport Mood disorders Atherogenicity Cardiovascular disease |
| url | https://doi.org/10.1186/s12888-025-06734-2 |
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