Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling
Ezrin is an actin binding protein connecting the cell membrane and the cytoskeleton, which is crucial to maintaining cell morphology, intercellular adhesion, and cytoskeleton remodeling. Asthma involves dysfunction of inflammatory cells, cytokines, and airway structural cells. Recent studies have sh...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/6255012 |
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| _version_ | 1850177666379939840 |
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| author | Shumei Zhao Jiaqi Luo Jun Hu Hesheng Wang Ningwei Zhao Meng Cao Cong Zhang Rongkui Hu Lanying Liu |
| author_facet | Shumei Zhao Jiaqi Luo Jun Hu Hesheng Wang Ningwei Zhao Meng Cao Cong Zhang Rongkui Hu Lanying Liu |
| author_sort | Shumei Zhao |
| collection | DOAJ |
| description | Ezrin is an actin binding protein connecting the cell membrane and the cytoskeleton, which is crucial to maintaining cell morphology, intercellular adhesion, and cytoskeleton remodeling. Asthma involves dysfunction of inflammatory cells, cytokines, and airway structural cells. Recent studies have shown that ezrin, whose function is affected by extensive phosphorylation and protein interactions, is closely associated with asthma, may be a therapeutic target for asthma treatment. In this review, we summarize studies on ezrin and discuss its role in asthma-related airway inflammation and remodeling. |
| format | Article |
| id | doaj-art-c352d4be15f3467084cb07455b06ecc9 |
| institution | OA Journals |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-c352d4be15f3467084cb07455b06ecc92025-08-20T02:18:55ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/6255012Role of Ezrin in Asthma-Related Airway Inflammation and RemodelingShumei Zhao0Jiaqi Luo1Jun Hu2Hesheng Wang3Ningwei Zhao4Meng Cao5Cong Zhang6Rongkui Hu7Lanying Liu8Affiliated Hospital of Nanjing University of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjing University of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineEzrin is an actin binding protein connecting the cell membrane and the cytoskeleton, which is crucial to maintaining cell morphology, intercellular adhesion, and cytoskeleton remodeling. Asthma involves dysfunction of inflammatory cells, cytokines, and airway structural cells. Recent studies have shown that ezrin, whose function is affected by extensive phosphorylation and protein interactions, is closely associated with asthma, may be a therapeutic target for asthma treatment. In this review, we summarize studies on ezrin and discuss its role in asthma-related airway inflammation and remodeling.http://dx.doi.org/10.1155/2022/6255012 |
| spellingShingle | Shumei Zhao Jiaqi Luo Jun Hu Hesheng Wang Ningwei Zhao Meng Cao Cong Zhang Rongkui Hu Lanying Liu Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling Mediators of Inflammation |
| title | Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling |
| title_full | Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling |
| title_fullStr | Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling |
| title_full_unstemmed | Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling |
| title_short | Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling |
| title_sort | role of ezrin in asthma related airway inflammation and remodeling |
| url | http://dx.doi.org/10.1155/2022/6255012 |
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