Inflammation as a Link between Obesity and Metabolic Syndrome
The metabolic syndrome is a complex of clinical features leading to an increased risk for cardiovascular disease and type 2 diabetes mellitus in both sexes. Visceral obesity and insulin resistance are considered the main features determining the negative cardiovascular profile in metabolic syndrome....
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2012/476380 |
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| author | Faloia Emanuela Michetti Grazia De Robertis Marco Luconi Maria Paola Furlani Giorgio Boscaro Marco |
| author_facet | Faloia Emanuela Michetti Grazia De Robertis Marco Luconi Maria Paola Furlani Giorgio Boscaro Marco |
| author_sort | Faloia Emanuela |
| collection | DOAJ |
| description | The metabolic syndrome is a complex of clinical features leading to an increased risk for cardiovascular disease and type 2 diabetes mellitus in both sexes. Visceral obesity and insulin resistance are considered the main features determining the negative cardiovascular profile in metabolic syndrome. The aim of this paper is to highlight the central role of obesity in the development of a chronic low-grade inflammatory state that leads to insulin resistance, endothelial and microvascular dysfunctions. It is thought that the starting signal of this inflammation is overfeeding and the pathway origins in all the metabolic cells; the subsequent increase in cytokine production recruits immune cells in the extracellular environment inducing an overall systemic inflammation. This paper focuses on the molecular and cellular inflammatory mechanisms studied until now. |
| format | Article |
| id | doaj-art-c33aefa7ecdd45538df72740824ee196 |
| institution | OA Journals |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-c33aefa7ecdd45538df72740824ee1962025-08-20T02:18:54ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322012-01-01201210.1155/2012/476380476380Inflammation as a Link between Obesity and Metabolic SyndromeFaloia Emanuela0Michetti Grazia1De Robertis Marco2Luconi Maria Paola3Furlani Giorgio4Boscaro Marco5Division of Endocrinology, Polytechnic University of Marche, via Conca 71, 60126 Ancona, ItalyDivision of Endocrinology, Polytechnic University of Marche, via Conca 71, 60126 Ancona, ItalyDivision of Endocrinology, Polytechnic University of Marche, via Conca 71, 60126 Ancona, ItalyDivision of Endocrinology, Polytechnic University of Marche, via Conca 71, 60126 Ancona, ItalyDivision of Endocrinology, Polytechnic University of Marche, via Conca 71, 60126 Ancona, ItalyDivision of Endocrinology, Polytechnic University of Marche, via Conca 71, 60126 Ancona, ItalyThe metabolic syndrome is a complex of clinical features leading to an increased risk for cardiovascular disease and type 2 diabetes mellitus in both sexes. Visceral obesity and insulin resistance are considered the main features determining the negative cardiovascular profile in metabolic syndrome. The aim of this paper is to highlight the central role of obesity in the development of a chronic low-grade inflammatory state that leads to insulin resistance, endothelial and microvascular dysfunctions. It is thought that the starting signal of this inflammation is overfeeding and the pathway origins in all the metabolic cells; the subsequent increase in cytokine production recruits immune cells in the extracellular environment inducing an overall systemic inflammation. This paper focuses on the molecular and cellular inflammatory mechanisms studied until now.http://dx.doi.org/10.1155/2012/476380 |
| spellingShingle | Faloia Emanuela Michetti Grazia De Robertis Marco Luconi Maria Paola Furlani Giorgio Boscaro Marco Inflammation as a Link between Obesity and Metabolic Syndrome Journal of Nutrition and Metabolism |
| title | Inflammation as a Link between Obesity and Metabolic Syndrome |
| title_full | Inflammation as a Link between Obesity and Metabolic Syndrome |
| title_fullStr | Inflammation as a Link between Obesity and Metabolic Syndrome |
| title_full_unstemmed | Inflammation as a Link between Obesity and Metabolic Syndrome |
| title_short | Inflammation as a Link between Obesity and Metabolic Syndrome |
| title_sort | inflammation as a link between obesity and metabolic syndrome |
| url | http://dx.doi.org/10.1155/2012/476380 |
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