MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers
Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-dependent nuclear receptors, which control the transcription of genes involved in energy homeostasis and inflammation and cell proliferation/differentiation. Alterations of PPARs’ expression and/or activity are commonly assoc...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2017/7058424 |
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| author | Dorothea Portius Cyril Sobolewski Michelangelo Foti |
| author_facet | Dorothea Portius Cyril Sobolewski Michelangelo Foti |
| author_sort | Dorothea Portius |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-dependent nuclear receptors, which control the transcription of genes involved in energy homeostasis and inflammation and cell proliferation/differentiation. Alterations of PPARs’ expression and/or activity are commonly associated with metabolic disorders occurring with obesity, type 2 diabetes, and fatty liver disease, as well as with inflammation and cancer. Emerging evidence now indicates that microRNAs (miRNAs), a family of small noncoding RNAs, which fine-tune gene expression, play a significant role in the pathophysiological mechanisms regulating the expression and activity of PPARs. Herein, the regulation of PPARs by miRNAs is reviewed in the context of metabolic disorders, inflammation, and cancer. The reciprocal control of miRNAs expression by PPARs, as well as the therapeutic potential of modulating PPAR expression/activity by pharmacological compounds targeting miRNA, is also discussed. |
| format | Article |
| id | doaj-art-c3374fbb0eb349b8a8c7187d5361add1 |
| institution | OA Journals |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-c3374fbb0eb349b8a8c7187d5361add12025-08-20T02:18:54ZengWileyPPAR Research1687-47571687-47652017-01-01201710.1155/2017/70584247058424MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and CancersDorothea Portius0Cyril Sobolewski1Michelangelo Foti2Department of Cell Physiology and Metabolism and Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, SwitzerlandDepartment of Cell Physiology and Metabolism and Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, SwitzerlandDepartment of Cell Physiology and Metabolism and Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, SwitzerlandPeroxisome proliferator-activated receptors (PPARs) are a family of ligand-dependent nuclear receptors, which control the transcription of genes involved in energy homeostasis and inflammation and cell proliferation/differentiation. Alterations of PPARs’ expression and/or activity are commonly associated with metabolic disorders occurring with obesity, type 2 diabetes, and fatty liver disease, as well as with inflammation and cancer. Emerging evidence now indicates that microRNAs (miRNAs), a family of small noncoding RNAs, which fine-tune gene expression, play a significant role in the pathophysiological mechanisms regulating the expression and activity of PPARs. Herein, the regulation of PPARs by miRNAs is reviewed in the context of metabolic disorders, inflammation, and cancer. The reciprocal control of miRNAs expression by PPARs, as well as the therapeutic potential of modulating PPAR expression/activity by pharmacological compounds targeting miRNA, is also discussed.http://dx.doi.org/10.1155/2017/7058424 |
| spellingShingle | Dorothea Portius Cyril Sobolewski Michelangelo Foti MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers PPAR Research |
| title | MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers |
| title_full | MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers |
| title_fullStr | MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers |
| title_full_unstemmed | MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers |
| title_short | MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers |
| title_sort | micrornas dependent regulation of ppars in metabolic diseases and cancers |
| url | http://dx.doi.org/10.1155/2017/7058424 |
| work_keys_str_mv | AT dorotheaportius micrornasdependentregulationofpparsinmetabolicdiseasesandcancers AT cyrilsobolewski micrornasdependentregulationofpparsinmetabolicdiseasesandcancers AT michelangelofoti micrornasdependentregulationofpparsinmetabolicdiseasesandcancers |