Exploring the roles and clinical potential of exosome-derived non-coding RNAs in glioma
Non-coding accounts for 98 %-99 % of the human genome and performs many essential regulatory functions in eukaryotes, involved in cancer development and development. Non-coding RNAs are abundantly enriched in exosomes, which play a biological role as vectors. Some biofunctional non-coding RNAs are s...
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Elsevier
2025-06-01
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| Series: | IBRO Neuroscience Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242125000156 |
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| author | Peng Jin Xue Bai |
| author_facet | Peng Jin Xue Bai |
| author_sort | Peng Jin |
| collection | DOAJ |
| description | Non-coding accounts for 98 %-99 % of the human genome and performs many essential regulatory functions in eukaryotes, involved in cancer development and development. Non-coding RNAs are abundantly enriched in exosomes, which play a biological role as vectors. Some biofunctional non-coding RNAs are specifically designed as exosomes for the treatment of cancers such as glioma. Glioma is one of the most common primary tumors within the skull and has varying degrees of malignancy and histologic subtypes of grades I-IV. Gliomas are characterized by high malignancy and an abundant blood supply due to rapid cell proliferation and vascularization, often with a poor prognosis. Exosomal non-coding RNAs can be involved in the tumorigenesis process of glioma from multiple directions, such as angiogenesis, tumor proliferation, metastatic invasion, immune evasion, apoptosis, and autophagy. Therefore, non-coding RNAs in exosomes are suitable as markers or therapeutic targets for early diagnosis of diseases and for predicting the prognosis of a variety of diseases. Regulating exosome production and the level of exosomal non-coding RNA expression may be a new approach to prevent or eliminate glioma. In this review, we review the origin and characteristics of exosomal non-coding RNAs, and introduce the functional studies of exosomal non-coding RNAs in glioma and their potential clinical applications, in order to broaden new ideas for the treatment of glioma. |
| format | Article |
| id | doaj-art-c33733eccfaf401bb3a47d8678c74358 |
| institution | Kabale University |
| issn | 2667-2421 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj-art-c33733eccfaf401bb3a47d8678c743582025-08-20T03:45:28ZengElsevierIBRO Neuroscience Reports2667-24212025-06-011832333710.1016/j.ibneur.2025.01.015Exploring the roles and clinical potential of exosome-derived non-coding RNAs in gliomaPeng Jin0Xue Bai1Department of Neurosurgery, Hulunbuir People’s Hospital, Hulunbuir, Inner Mongolia Autonomous Region 021000, ChinaDepartment of Intensive Care Unit, Hulunbuir People’s Hospital, No. 20, Shengli Street, Hailar District, Hulunbuir, Inner Mongolia Autonomous Region 021000, China; Corresponding author.Non-coding accounts for 98 %-99 % of the human genome and performs many essential regulatory functions in eukaryotes, involved in cancer development and development. Non-coding RNAs are abundantly enriched in exosomes, which play a biological role as vectors. Some biofunctional non-coding RNAs are specifically designed as exosomes for the treatment of cancers such as glioma. Glioma is one of the most common primary tumors within the skull and has varying degrees of malignancy and histologic subtypes of grades I-IV. Gliomas are characterized by high malignancy and an abundant blood supply due to rapid cell proliferation and vascularization, often with a poor prognosis. Exosomal non-coding RNAs can be involved in the tumorigenesis process of glioma from multiple directions, such as angiogenesis, tumor proliferation, metastatic invasion, immune evasion, apoptosis, and autophagy. Therefore, non-coding RNAs in exosomes are suitable as markers or therapeutic targets for early diagnosis of diseases and for predicting the prognosis of a variety of diseases. Regulating exosome production and the level of exosomal non-coding RNA expression may be a new approach to prevent or eliminate glioma. In this review, we review the origin and characteristics of exosomal non-coding RNAs, and introduce the functional studies of exosomal non-coding RNAs in glioma and their potential clinical applications, in order to broaden new ideas for the treatment of glioma.http://www.sciencedirect.com/science/article/pii/S2667242125000156RNAExosomesGliomaBiomarkersSignaling transduction |
| spellingShingle | Peng Jin Xue Bai Exploring the roles and clinical potential of exosome-derived non-coding RNAs in glioma IBRO Neuroscience Reports RNA Exosomes Glioma Biomarkers Signaling transduction |
| title | Exploring the roles and clinical potential of exosome-derived non-coding RNAs in glioma |
| title_full | Exploring the roles and clinical potential of exosome-derived non-coding RNAs in glioma |
| title_fullStr | Exploring the roles and clinical potential of exosome-derived non-coding RNAs in glioma |
| title_full_unstemmed | Exploring the roles and clinical potential of exosome-derived non-coding RNAs in glioma |
| title_short | Exploring the roles and clinical potential of exosome-derived non-coding RNAs in glioma |
| title_sort | exploring the roles and clinical potential of exosome derived non coding rnas in glioma |
| topic | RNA Exosomes Glioma Biomarkers Signaling transduction |
| url | http://www.sciencedirect.com/science/article/pii/S2667242125000156 |
| work_keys_str_mv | AT pengjin exploringtherolesandclinicalpotentialofexosomederivednoncodingrnasinglioma AT xuebai exploringtherolesandclinicalpotentialofexosomederivednoncodingrnasinglioma |