Cardiac Biomarkers in a Brazilian Indigenous Population Exposed to Arboviruses: A Cross-Sectional Study
Arthropod-borne viral diseases are acute febrile illnesses, sometimes with chronic effects, that can be debilitating and even fatal worldwide, affecting particularly vulnerable populations. Indigenous communities face not only the burden of these acute febrile illnesses, but also the cardiovascular...
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2024-12-01
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| author | Jandir Mendonça Nicacio Carlos Dornels Freire de Souza Orlando Vieira Gomes Beatriz Vasconcelos Souza João Augusto Costa Lima Rodrigo Feliciano do Carmo Sávio Luiz Pereira Nunes Vanessa Cardoso Pereira Naiara de Souza Barros Ana Luiza Santos de Melo Lucca Gabriel Feitosa Lourencini Jurandy Júnior Ferraz de Magalhães Diego Guerra de Albuquerque Cabral Ricardo Khouri Manoel Barral-Netto Anderson da Costa Armstrong |
| author_facet | Jandir Mendonça Nicacio Carlos Dornels Freire de Souza Orlando Vieira Gomes Beatriz Vasconcelos Souza João Augusto Costa Lima Rodrigo Feliciano do Carmo Sávio Luiz Pereira Nunes Vanessa Cardoso Pereira Naiara de Souza Barros Ana Luiza Santos de Melo Lucca Gabriel Feitosa Lourencini Jurandy Júnior Ferraz de Magalhães Diego Guerra de Albuquerque Cabral Ricardo Khouri Manoel Barral-Netto Anderson da Costa Armstrong |
| author_sort | Jandir Mendonça Nicacio |
| collection | DOAJ |
| description | Arthropod-borne viral diseases are acute febrile illnesses, sometimes with chronic effects, that can be debilitating and even fatal worldwide, affecting particularly vulnerable populations. Indigenous communities face not only the burden of these acute febrile illnesses, but also the cardiovascular complications that are worsened by urbanization. A cross-sectional study was conducted in an Indigenous population in the Northeast Region of Brazil to explore the association between arboviral infections (dengue, chikungunya, and Zika) and cardiac biomarkers, including cardiotrophin 1, growth differentiation factor 15, lactate dehydrogenase B, fatty-acid-binding protein 3, myoglobin, N-terminal pro-B-type natriuretic peptide, cardiac troponin I, big endothelin 1, and creatine kinase-MB, along with clinical and anthropometric factors. The study included 174 individuals from the Fulni-ô community, with a median age of 47 years (interquartile range 39.0 to 56.0). High rates of previous exposure to dengue, chikungunya, and Zika were observed (92.5%, 78.2%, and 95.4% anti-IgG, respectively), while acute exposure (anti-IgM) remained low. The biomarkers were linked to age (especially in the elderly), obesity, chronic kidney disease, and previous or recent exposure to chikungunya. This study pioneers the use of Luminex xMAP technology to reveal the association between cardiac inflammatory biomarkers and exposure to classical arboviruses in an Indigenous population undergoing urbanization. |
| format | Article |
| id | doaj-art-c3329625e64c4618ab0ca3c2bf194dc8 |
| institution | OA Journals |
| issn | 1999-4915 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-c3329625e64c4618ab0ca3c2bf194dc82025-08-20T02:01:14ZengMDPI AGViruses1999-49152024-12-011612190210.3390/v16121902Cardiac Biomarkers in a Brazilian Indigenous Population Exposed to Arboviruses: A Cross-Sectional StudyJandir Mendonça Nicacio0Carlos Dornels Freire de Souza1Orlando Vieira Gomes2Beatriz Vasconcelos Souza3João Augusto Costa Lima4Rodrigo Feliciano do Carmo5Sávio Luiz Pereira Nunes6Vanessa Cardoso Pereira7Naiara de Souza Barros8Ana Luiza Santos de Melo9Lucca Gabriel Feitosa Lourencini10Jurandy Júnior Ferraz de Magalhães11Diego Guerra de Albuquerque Cabral12Ricardo Khouri13Manoel Barral-Netto14Anderson da Costa Armstrong15Faculty of Medicine, Federal University of Vale do São Francisco—UNIVASF, Petrolina 56304-917, PE, BrazilFaculty of Medicine, Federal University of Vale do São Francisco—UNIVASF, Petrolina 56304-917, PE, BrazilFaculty of Medicine, Federal University of Vale do São Francisco—UNIVASF, Petrolina 56304-917, PE, BrazilPostgraduate Program in Human Pathology, Faculty of Medicine of Bahia, Federal University of Bahia, Salvador 40026-010, BA, BrazilCardiology, Johns Hopkins University, Baltimore, MD 21205, USAFaculty of Medicine, Federal University of Vale do São Francisco—UNIVASF, Petrolina 56304-917, PE, BrazilPostgraduate Program in Applied Cellular and Molecular Biology, University of Pernambuco-UPE, Recife 50100-010, PE, BrazilPostgraduate Program in Human Ecology and Socio-Environmental Management, Bahia State University—UNEB, Juazeiro 48904-711, BA, BrazilCollegiate of Medicine, Faculty of Medicine, Federal University of Vale do São Francisco—UNIVASF, Petrolina Campus, Petrolina 56304-917, PE, BrazilCollegiate of Medicine, Faculty of Medicine, Federal University of Vale do São Francisco—UNIVASF, Petrolina Campus, Petrolina 56304-917, PE, BrazilCollegiate of Medicine, Faculty of Medicine, Federal University of Vale do São Francisco—UNIVASF, Petrolina Campus, Petrolina 56304-917, PE, BrazilCollege of Medicine-Serra Talhada Campus-UPE/ST, University of Pernambuco, Serra Talhada 56909-205, PE, BrazilCentral Public Health Laboratory of Pernambuco—LACEN, Recife 50050-215, PE, BrazilOswaldo Cruz Foundation/Fiocruz, Institute Gonçalo Moniz, Salvador 40296-710, BA, BrazilOswaldo Cruz Foundation/Fiocruz, Institute Gonçalo Moniz, Salvador 40296-710, BA, BrazilFaculty of Medicine, Federal University of Vale do São Francisco—UNIVASF, Petrolina 56304-917, PE, BrazilArthropod-borne viral diseases are acute febrile illnesses, sometimes with chronic effects, that can be debilitating and even fatal worldwide, affecting particularly vulnerable populations. Indigenous communities face not only the burden of these acute febrile illnesses, but also the cardiovascular complications that are worsened by urbanization. A cross-sectional study was conducted in an Indigenous population in the Northeast Region of Brazil to explore the association between arboviral infections (dengue, chikungunya, and Zika) and cardiac biomarkers, including cardiotrophin 1, growth differentiation factor 15, lactate dehydrogenase B, fatty-acid-binding protein 3, myoglobin, N-terminal pro-B-type natriuretic peptide, cardiac troponin I, big endothelin 1, and creatine kinase-MB, along with clinical and anthropometric factors. The study included 174 individuals from the Fulni-ô community, with a median age of 47 years (interquartile range 39.0 to 56.0). High rates of previous exposure to dengue, chikungunya, and Zika were observed (92.5%, 78.2%, and 95.4% anti-IgG, respectively), while acute exposure (anti-IgM) remained low. The biomarkers were linked to age (especially in the elderly), obesity, chronic kidney disease, and previous or recent exposure to chikungunya. This study pioneers the use of Luminex xMAP technology to reveal the association between cardiac inflammatory biomarkers and exposure to classical arboviruses in an Indigenous population undergoing urbanization.https://www.mdpi.com/1999-4915/16/12/1902arbovirusescardiac involvementdenguechikungunyaZikacardiac biomarkers |
| spellingShingle | Jandir Mendonça Nicacio Carlos Dornels Freire de Souza Orlando Vieira Gomes Beatriz Vasconcelos Souza João Augusto Costa Lima Rodrigo Feliciano do Carmo Sávio Luiz Pereira Nunes Vanessa Cardoso Pereira Naiara de Souza Barros Ana Luiza Santos de Melo Lucca Gabriel Feitosa Lourencini Jurandy Júnior Ferraz de Magalhães Diego Guerra de Albuquerque Cabral Ricardo Khouri Manoel Barral-Netto Anderson da Costa Armstrong Cardiac Biomarkers in a Brazilian Indigenous Population Exposed to Arboviruses: A Cross-Sectional Study Viruses arboviruses cardiac involvement dengue chikungunya Zika cardiac biomarkers |
| title | Cardiac Biomarkers in a Brazilian Indigenous Population Exposed to Arboviruses: A Cross-Sectional Study |
| title_full | Cardiac Biomarkers in a Brazilian Indigenous Population Exposed to Arboviruses: A Cross-Sectional Study |
| title_fullStr | Cardiac Biomarkers in a Brazilian Indigenous Population Exposed to Arboviruses: A Cross-Sectional Study |
| title_full_unstemmed | Cardiac Biomarkers in a Brazilian Indigenous Population Exposed to Arboviruses: A Cross-Sectional Study |
| title_short | Cardiac Biomarkers in a Brazilian Indigenous Population Exposed to Arboviruses: A Cross-Sectional Study |
| title_sort | cardiac biomarkers in a brazilian indigenous population exposed to arboviruses a cross sectional study |
| topic | arboviruses cardiac involvement dengue chikungunya Zika cardiac biomarkers |
| url | https://www.mdpi.com/1999-4915/16/12/1902 |
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