Tolterodine is a novel candidate for assessing CYP3A4 activity through metabolic volatiles to predict drug responses

Tolterodine is a novel candidate for assessing CYP3A4 activity through metabolic volatiles to predict drug responses

Abstract Cytochrome P450 (CYP) 3A4 plays a major role in drug metabolism. Its activity could be determined by non-invasive and cost-effective assays, such as breath analysis, for the personalised monitoring of drug response. For the first time, we identify an isotopically unlabelled CYP3A4 substrate...

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Bibliographic Details
Main Authors: Valentina Stock, Rebecca Hofer, Franziska Lochmann, Vera Spanke, Klaus R. Liedl, Jakob Troppmair, Thierry Langer, Hubert Gstach, Christian Dank, Chris A. Mayhew, Sarah Kammerer, Veronika Ruzsanyi
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Breath test
CYP3A4
HepG2
Tolterodine
Acetone
Volatile biomarkers
Online Access:https://doi.org/10.1038/s41598-025-86450-9
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